针对患者报告结果检测信息系统(PROMIS)构建儿童哮喘影响量表
2010/07/06
背景：最近，医学研究健康路线图国家研究所启动了此项患者报告结果检测信息系统测量信息系统（PROMIS）。PROMIS的主要目的是为临床研究机构开发一套项目资料库，并进行电脑适应性测试。哮喘为儿童最为常见的慢性疾病，选为儿童特异性项目资料库。
目的：本试验旨在哮喘评价项目中提供详细心理计量学分析。
方法：采用项目反应理论（IRT）对34个项目进行分析。测试形式包括PROMIS儿科哮喘项目。受试者为622名年龄在8～12岁之间的儿童。随后对项目评价其局部依赖性、测量维度和不同的项目功能。
结果：应用IRT法分析，形成针对PROMIS的儿童哮喘影响量表（PAIS），包含17个项目组成的资料库和8条项目简表。在T评分计量的平均值（50）时，推荐的8条项目组成的简表能提供最大检测信息。如果需要更高得分，推荐使用17个项目组成的资料库，可以全部使用或根据电脑测试（CAT）结果选择。简短的测试简表也可以实现相同的测量。
结论：IRT法研发的PROMIS儿童哮喘影响量表(PAIS)，为每条项目提供了初始校准数据。
（林江涛 审校）
Yeatts KB, et al. J Asthma. 2010 Apr;47(3):295-302.
Construction of the Pediatric Asthma Impact Scale (PAIS) for the Patient-Reported Outcomes Measurement Information System (PROMIS).
Yeatts KB, Stucky B, Thissen D, Irwin D, Varni JW, DeWitt EM, Lai JS, DeWalt DA.
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27510, USA. Karin Yeatts@unc.edu
Abstract
Background: Recently, the National Institutes of Health Roadmap for Medical Research initiative led a large-scale effort to develop the Patient-Reported Outcomes Measurement Information System (PROMIS). PROMIS’s main goal was to develop a set of item banks and computerized adaptive tests for the clinical research community. Asthma, as the most common chronic childhood disease, was chosen for a disease-specific pediatric item bank.
OBJECTIVES: The primary objective of this research is to present the details of the psychometric analyses of the asthma domain items.
METHODS: Item response theory (IRT) analyses were conducted on a 34-asthma item bank. Test forms containing PROMIS Pediatric Asthma domain items were completed by 622 children ages 8 to 12. Items were subsequently evaluated for local dependence, scale dimensionality, and differential item functioning.
RESULTS: A 17-item pool and an 8-item short form for the new PROMIS Pediatric Asthma Impact Scale (PAIS) were generated using IRT. The recommended 8-item short form contains the item set that provides the maximum test information at the mean (50) on the T-score metric. If more score precision is required, the complete 17-item pool is recommended and may be used in toto or as the basis of a computerized adaptive test (CAT). A shorter test form can also be created and scored on the same scale.
CONCLUSIONS: The present study presents the PROMIS Pediatric Asthma Impact Scale (PAIS) developed with IRT, and provides the initial calibration data for the items.
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儿童夜间睡眠间歇性喘息
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成人和儿童未控制哮喘的预测因子：哮喘控制特征分析和现患调查研究（ACCESS）
