儿童期经常性夜间觉醒与非过敏性哮喘有关
2010/02/03
儿童睡眠剥夺在西方国家较为常见，且与诸多疾病有关。本试验是一项社区的出生队列研究，旨在对儿童期经常性夜间觉醒与儿童哮喘的关系进行回顾性纵向研究。对1989～1991年间澳大利亚珀斯一家医院出生的2,398名儿童进行随访研究（1，2，3，6，8，10及14岁）。对儿童父母完成的问卷调查进行分析。6岁及14岁时儿童哮喘与3岁以内经常性夜间觉醒的关系采用多元逻辑性回归分析其优势比。对哮喘危险因素校正后，睡眠及家庭应激、持续性夜间觉醒与儿童6岁和14岁时的患非过敏性哮喘相关（14 岁: OR 2.18, 95% CI 1.15-4.13），但与过敏性哮喘无关。同时，结果显示，3岁以内经常性觉醒的儿童患非过敏性哮喘的风险增加。
上述结果表明，有必要对儿童期睡眠障碍对哮喘发生的影响进行系统性研究。
（ 苏楠 审校）
Eur Respir J. 2009 Dec;34(6):1288-1295.
Frequent nocturnal awakening in early life is associated with nonatopic asthma in children.
Kozyrskyj AL, Kendall GE, Zubrick SR, Newnham JP, Sly PD.
Dept of Paediatrics, University of Alberta, Edmonton, AB, Canada.
Sleep deprivation has become a common phenomenon of the Western world and is associated with a variety of medical problems in children. This retrospective longitudinal analysis of a community-based birth cohort was undertaken to determine whether frequent nocturnal awakening during early life was associated with the development of childhood asthma. 2,398 children born to mothers recruited from the antenatal clinics of a single hospital in Perth, Australia during 1989-1991 were followed up at years 1, 2, 3, 6, 8, 10 and 14. Parent-completed questionnaires were analysed. The odds ratio for asthma at age 6 and 14 yrs in children with frequent nocturnal awakening during the first 3 yrs after birth was determined from multiple logistic regression. Following adjustment for asthma risk factors, co-sleeping and family stress, persistent nocturnal awakening was associated with nonatopic asthma at age 6 and 14 yrs (at age 14 yrs: OR 2.18, 95% CI 1.15-4.13) but not with atopic asthma. We found an increased risk of nonatopic asthma in children following frequent nocturnal awakening during the first 3 yrs of life. These hypothesis-generating data suggest the need for further systematic study of the effects of disordered sleep in early life on the development of asthma.
Eur Respir J. 2009 Dec;34(6):1288-1295.
上述结果表明，有必要对儿童期睡眠障碍对哮喘发生的影响进行系统性研究。
（ 苏楠 审校）
Eur Respir J. 2009 Dec;34(6):1288-1295.
Frequent nocturnal awakening in early life is associated with nonatopic asthma in children.
Kozyrskyj AL, Kendall GE, Zubrick SR, Newnham JP, Sly PD.
Dept of Paediatrics, University of Alberta, Edmonton, AB, Canada.
Sleep deprivation has become a common phenomenon of the Western world and is associated with a variety of medical problems in children. This retrospective longitudinal analysis of a community-based birth cohort was undertaken to determine whether frequent nocturnal awakening during early life was associated with the development of childhood asthma. 2,398 children born to mothers recruited from the antenatal clinics of a single hospital in Perth, Australia during 1989-1991 were followed up at years 1, 2, 3, 6, 8, 10 and 14. Parent-completed questionnaires were analysed. The odds ratio for asthma at age 6 and 14 yrs in children with frequent nocturnal awakening during the first 3 yrs after birth was determined from multiple logistic regression. Following adjustment for asthma risk factors, co-sleeping and family stress, persistent nocturnal awakening was associated with nonatopic asthma at age 6 and 14 yrs (at age 14 yrs: OR 2.18, 95% CI 1.15-4.13) but not with atopic asthma. We found an increased risk of nonatopic asthma in children following frequent nocturnal awakening during the first 3 yrs of life. These hypothesis-generating data suggest the need for further systematic study of the effects of disordered sleep in early life on the development of asthma.
Eur Respir J. 2009 Dec;34(6):1288-1295.
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儿童哮喘气道炎症和气道重塑的无创性标记物
