使哮喘患者的咳嗽反射中止
2010/02/03
目的：咳嗽是哮喘的确诊症状之一，但一般来说，哮喘诊断更多的注重喘息、胸闷和呼吸急促等症状。咳嗽对患者的影响可能远大于我们目前所了解的，大大超过喘息、胸闷和睡眠障碍对患者的影响。
近期发现：对哮喘患者咳嗽症状进行客观测定的研究显示，哮喘患者的咳嗽频率变化范围较大，可以与健康志愿者一样很少咳嗽，也可如同慢性咳嗽，但哮喘患者咳嗽的触发因素尚不清楚。本综述主要讨论目前对哮喘患者咳嗽的了解、促发咳嗽的潜在机制、目前治疗的效果及将来可能的治疗方法。
总结：对某些哮喘患者，咳嗽是一个重要问题，因此在临床实践和临床研究中需更加关注咳嗽症状。
（刘国梁 审校）
Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):77-81.
Interrupting the cough reflex in asthma.
Smith JA.
University of Manchester, UK.
PURPOSE OF REVIEW: Although cough is one of the defining symptoms of asthma, wheeze, chest tightness and breathlessness have generally received more attention. The impact of coughing for patients may be more important than currently appreciated and has been rated more troublesome than wheeze, chest tightness or disturbance of sleep.
RECENT FINDINGS: Studies objectively measuring cough in asthma reveal that cough frequencies vary from those similar to healthy volunteers to cough counts comparable to patients presenting with chronic cough, but the potential triggers for cough in asthma are poorly understood. This review discusses our current knowledge of cough in asthma, potential mechanisms that may provoke coughing, the effect of current treatments and possible future therapeutics.
SUMMARY: Cough in some asthma patients is a significant problem, deserving further attention in both clinical practice and clinical research.
Smith JA.Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):77-81.
近期发现：对哮喘患者咳嗽症状进行客观测定的研究显示，哮喘患者的咳嗽频率变化范围较大，可以与健康志愿者一样很少咳嗽，也可如同慢性咳嗽，但哮喘患者咳嗽的触发因素尚不清楚。本综述主要讨论目前对哮喘患者咳嗽的了解、促发咳嗽的潜在机制、目前治疗的效果及将来可能的治疗方法。
总结：对某些哮喘患者，咳嗽是一个重要问题，因此在临床实践和临床研究中需更加关注咳嗽症状。
（刘国梁 审校）
Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):77-81.
Interrupting the cough reflex in asthma.
Smith JA.
University of Manchester, UK.
PURPOSE OF REVIEW: Although cough is one of the defining symptoms of asthma, wheeze, chest tightness and breathlessness have generally received more attention. The impact of coughing for patients may be more important than currently appreciated and has been rated more troublesome than wheeze, chest tightness or disturbance of sleep.
RECENT FINDINGS: Studies objectively measuring cough in asthma reveal that cough frequencies vary from those similar to healthy volunteers to cough counts comparable to patients presenting with chronic cough, but the potential triggers for cough in asthma are poorly understood. This review discusses our current knowledge of cough in asthma, potential mechanisms that may provoke coughing, the effect of current treatments and possible future therapeutics.
SUMMARY: Cough in some asthma patients is a significant problem, deserving further attention in both clinical practice and clinical research.
Smith JA.Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):77-81.
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反流性咳嗽新进展
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吸烟对人咳嗽反射敏感性的影响
