环索奈德对运动员哮喘的疗效
2010/02/02
背景:有研究显示运动员支气管哮喘发病率高于普通人群,但对运动员支气管哮喘治疗的有效性却了解较少。
目的:本试验旨在研究日本新泻县运动员哮喘治疗的疗效。
方法:本文对运动员支气管哮喘进行回顾性研究。哮喘诊断依据全球哮喘防治倡议(GINA)。2007年1月~2008年6月新泻县健康与运动医学研究所就诊的运动员入选本研究。患者分为两组,分别采用环索奈德(CIC)和孟鲁司特治疗,疗程至少3个月。比较两组患者临床症状、肺功能参数及呼出气一氧化氮分数(FENO)的差异。
结果:治疗前,两组患者性别、年龄、症状发生频率、肺功能参数及其他检测参数未见显著差异。与孟鲁司特组患者相比,CIC组患者哮喘症状控制较好,治疗变化较小。CIC组患者肺功能和FENO有所改善,但孟鲁司特组患者上述指标未见显著改变。
结论:结果显示,对运动员哮喘,CIC较孟鲁司特更能控制哮喘,但尚需更多研究证实。
(林江涛 审校)
J Asthma. 2009 Dec; 46(10):1032-1036.
Effect of ciclesonide on bronchial asthma in athletes.
Koya T, Hasegawa T, Tanaka J, Kawakami H, Hayashi M, Kagamu H, Narita I, Arakawa M, Suzuki E.
Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University, Graduate School of Medical and Dental Sciences, Niigata City, Niigata, Japan.
BACKGROUND: Although it is well established that the incidence of bronchial asthma is higher in the athlete population than in the general population, little information exists about the efficacy of treatment of bronchial asthma in the athlete population.
OBJECTIVES: We conducted this study with the objective of determining the efficacy of treatment of bronchial asthma in an athlete population living in Niigata Prefecture, Japan.
METHODS: We conducted a retrospective study of bronchial asthma in an athlete population. Athletes diagnosed as having asthma, based on the Global Initiatives for Asthma (GINA) guidelines, who visited the Niigata Institute for Health and Sports Medicine between January 2007 and June 2008 were enrolled in this study. We compared two groups of patients, a group treated with ciclesonide (CIC) alone and another treated with montelukast alone, with the treatment duration lasting at least 3 months in both groups. The CIC or montelukast groups were compared in terms of the clinical symptoms, pulmonary function parameters, and fraction of exhaled nitric oxide (FENO).
RESULTS: There were no significant differences in the sex distribution, age, frequency of symptoms, pulmonary function parameters, or other examination data before treatment between the CIC and montelukast groups. The CIC group tended to show better symptom control and to need fewer changes of treatment than the montelukast group. While improvements of the pulmonary function parameters and FENO values were observed in the CIC group, no significant changes of these parameters were observed in the montelukast group.
CONCLUSIONS: These data suggest that CIC offers greater promise for the control of asthma than montelukast in the athlete population, although further investigation is required.
J Asthma. 2009 Dec; 46(10):1032-6.