抗氧化维生素与哮喘预后评估之间的关系:文献复习与meta-分析
2010/01/07
流行病学调查研究发现饮食中摄入维生素A.C.E可能与哮喘发病有关。为评估日常饮食摄入的维生素A.C.E量或血清中各指标的水平与哮喘是否有关，S Allen等人复习既往符合并将文献内容进行meta分析。他们收集了MEDLINE, EMBASE, CINAHL, CAB 摘要和 AMED等各大数据库中的文献,会议记要和论文书籍等资料(时间截至2007年11月)，筛出符合MOOSE指南的相关研究的文献共40篇，通过随机效应模型算出OR值和平均差(MD)，评估哮喘喘息气道高反应与饮食摄入和血清中维生素A.C.E水平之间的关系。
统计结果发现：哮喘患者饮食中摄入维生素A水平较无哮喘人群低(MD –182 µg/day, 95% CI –288 to –75; 3 项研究)；重症哮喘患者饮食中摄入维生素A量较轻度哮喘患者低(MD –344 µg/day; 2 项研究)；饮食摄入和血清中较低量的维生素C也与哮喘患病率的增加呈相关性(OR 1.12, 95% CI 1.04 to 1.21; 9项研究)；维生素E的摄入含量普遍与哮喘发病无关，但在重度哮喘患者中维生素E摄入明显比轻度哮喘患者低(MD –1.20 µg/day, 95% CI –2.3 to –0.1; 2项研究)。
S Allen等人的研究结果表明饮食中摄入维生素A和C含量低与哮喘或喘息发病率增加有关，具有统计学意义。维生素E的摄入与哮喘状态未见明显相关性。
（于娜 中国医科大学附属第一医院呼吸内科 110001 摘译）
（Thorax 2009;64:610-619）
Copyright © 2009 BMJ Publishing Group Ltd & British Thoracic Society.
ASTHMA
Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis
S Allen, J R Britton and J A Leonardi-Bee
Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
Correspondence to:
Dr J Leonardi-Bee, Division of Epidemiology and Public Health, Clinical Sciences Building, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK; jo.leonardi-bee@nottingham.ac.uk
Background: Epidemiological studies suggest that dietary intake of vitamins A, C and E may be associated with the occurrence of asthma. A systematic review and meta-analysis was conducted in accordance with MOOSE guidelines to determine whether vitamins A, C and E, measured as dietary intakes or serum levels, are associated with asthma.
Methods: (up to November 2007), conference proceedings and bibliographies of papers were searched to identify studies of asthma, wheeze or airway responsiveness in relation to intakes and serum concentrations of vitamins A, C and E. Pooled odds ratios (OR) or mean differences (MD) with 95% confidence intervals (CI) were estimated using random effects models.
Results: A total of 40 studies were included. Dietary vitamin A intake was significantly lower in people with asthma than in those without asthma (MD –182 µg/day, 95% CI –288 to –75; 3 studies) and in people with severe asthma than in those with mild asthma (MD –344 µg/day; 2 studies). Lower quantile dietary intakes (OR 1.12, 95% CI 1.04 to 1.21; 9 studies) and serum levels of vitamin C were also associated with an increased odds of asthma. Vitamin E intake was generally unrelated to asthma status but was significantly lower in severe asthma than in mild asthma (MD –1.20 µg/day, 95% CI –2.3 to –0.1; 2 studies).
Conclusions: Relatively low dietary intakes of vitamins A and C are associated with statistically significant increased odds of asthma and wheeze. Vitamin E intake does not appear to be related to asthma status.
Published Online First: 30 April 2009. doi:10.1136/thx.2008.101469
Thorax 2009;64:610-619
统计结果发现：哮喘患者饮食中摄入维生素A水平较无哮喘人群低(MD –182 µg/day, 95% CI –288 to –75; 3 项研究)；重症哮喘患者饮食中摄入维生素A量较轻度哮喘患者低(MD –344 µg/day; 2 项研究)；饮食摄入和血清中较低量的维生素C也与哮喘患病率的增加呈相关性(OR 1.12, 95% CI 1.04 to 1.21; 9项研究)；维生素E的摄入含量普遍与哮喘发病无关，但在重度哮喘患者中维生素E摄入明显比轻度哮喘患者低(MD –1.20 µg/day, 95% CI –2.3 to –0.1; 2项研究)。
S Allen等人的研究结果表明饮食中摄入维生素A和C含量低与哮喘或喘息发病率增加有关，具有统计学意义。维生素E的摄入与哮喘状态未见明显相关性。
（于娜 中国医科大学附属第一医院呼吸内科 110001 摘译）
（Thorax 2009;64:610-619）
Copyright © 2009 BMJ Publishing Group Ltd & British Thoracic Society.
ASTHMA
Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis
S Allen, J R Britton and J A Leonardi-Bee
Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
Correspondence to:
Dr J Leonardi-Bee, Division of Epidemiology and Public Health, Clinical Sciences Building, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK; jo.leonardi-bee@nottingham.ac.uk
Background: Epidemiological studies suggest that dietary intake of vitamins A, C and E may be associated with the occurrence of asthma. A systematic review and meta-analysis was conducted in accordance with MOOSE guidelines to determine whether vitamins A, C and E, measured as dietary intakes or serum levels, are associated with asthma.
Methods: (up to November 2007), conference proceedings and bibliographies of papers were searched to identify studies of asthma, wheeze or airway responsiveness in relation to intakes and serum concentrations of vitamins A, C and E. Pooled odds ratios (OR) or mean differences (MD) with 95% confidence intervals (CI) were estimated using random effects models.
Results: A total of 40 studies were included. Dietary vitamin A intake was significantly lower in people with asthma than in those without asthma (MD –182 µg/day, 95% CI –288 to –75; 3 studies) and in people with severe asthma than in those with mild asthma (MD –344 µg/day; 2 studies). Lower quantile dietary intakes (OR 1.12, 95% CI 1.04 to 1.21; 9 studies) and serum levels of vitamin C were also associated with an increased odds of asthma. Vitamin E intake was generally unrelated to asthma status but was significantly lower in severe asthma than in mild asthma (MD –1.20 µg/day, 95% CI –2.3 to –0.1; 2 studies).
Conclusions: Relatively low dietary intakes of vitamins A and C are associated with statistically significant increased odds of asthma and wheeze. Vitamin E intake does not appear to be related to asthma status.
Published Online First: 30 April 2009. doi:10.1136/thx.2008.101469
Thorax 2009;64:610-619
