VRGF多态性和儿童哮喘、肺功能和气道反应性的关系
2010/01/07
关键词：气流阻塞；哮喘；单核苷酸多态性；血管内皮生长因子
血管内皮生长因子（Vascular endothelial growth factor, VEGF）是与哮喘严重性密切相关，而VEGF单核苷酸多态性（single nucleotide polymorphisms, SNPs）决定了VEGF的水平和功能。为了阐明VEGF多态性与哮喘、肺功能和气道反应性的关系，Sharma等研究分析了儿童哮喘控制计划（Childhood Asthma Management Program, CAMP）中458个白人家庭的10个SNPs。
研究应用PBAT 软件(Golden Helix, Inc. Bozeman, MT, USA)分析SNPs与哮喘、肺功能和气道反应性的关联；以家庭和人口为基础重复测定气流阻塞程度。并在哥斯达黎加的412例哮喘儿童及其父母中重复研究。
在两个队列研究中均可发现SNPs与哮喘、肺功能或气道反应性的相关性。SNP rs833058与哮喘发病有关，rs4711750及其单倍体均与FEV1/FVC有关。纵向研究也证实在4.5年的观察期内rs4711750与FEV1/FVC间存在相关性。
研究表明，VEGF多态性与儿童期哮喘、肺功能和气道反应性相关，提示VEGF多态性影响了哮喘的易感性、气流阻塞和气道反应性。
（韩伟 青岛市市立医院东院呼吸科 266071 摘译）
（Eur Respir J 2009; 33:1287-1294）
Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness
S. Sharma1,2,3,4, A. J. Murphy1,3,4, M. E. Soto-Quiros5, L. Avila5, B. J. Klanderman1,3,4, J. S. Sylvia1,4, J. C. Celedón1,2,3,4, B. A. Raby1,2,3,4 and S. T. Weiss1,3,4
Keywords: Airflow obstruction, asthma, single nucleotide polymorphisms, vascular endothelial growth factor
Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity. The objective of the present study was to determine whether are associated with asthma, lung function and airway responsiveness.
The present authors analysed 10 SNPs in 458 white families in the Childhood Asthma Management Program (CAMP). Tests of association with asthma, lung function and airway responsiveness were performed using PBAT software (Golden Helix, Inc. Bozeman, MT, USA; available at www.goldenhelix.com). Family and population-based, revpeated measures analysis of airflow obstruction were conducted. Replication studies were performed in 412 asthmatic children and their parents from Costa Rica.
Associations with asthma, lung function and airway responsiveness were observed in both cohorts. SNP rs833058 was associated with asthma in both cohorts. This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV1/FVC decline over 
4.5 yrs of observation.
4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness
Eur Respir J 2009; 33:1287-1294
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胰岛素样生长因子结合蛋白-3在变应性气道重塑中的作用
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PHF11基因与哮喘或哮喘表型之间不相关---一项在两组不同种群中的研究
