老年哮喘：目前认识及未来方向
2009/12/15
综述目的：哮喘是老年人群的常见疾病，老年哮喘常常被漏诊或缺乏有效治疗。本文综述目前对老年哮喘（AIE）的认识以及AIE诊断和处理的挑战，阐述未来研究方向。
近期发现：过去几年内，AIE领域原创性研究较少，目前文献主要是一些综述性文章。AIE常常与多种疾病并存，因而导致其病程和治疗更为复杂。对于非过敏性哮喘，观点有所更新。呼吸道感染、超抗原、蛋白酶和白介素17引起的T辅助细胞1炎症是其可能的发病机制。系统性炎症与哮喘存在显著相关性。
总结：AIE的诊断和治疗需要对患者的特异性触发因素及可能的病理生理学进行全面了解。对这部分人群炎症机制的研究是改善干预治疗效果的关键步骤。
（ 陈欣 审校）
Curr Opin Pulm Med. 2009 Oct 19. [Epub ahead of print]
Asthma in the elderly: current knowledge and future directions.
King MJ, Hanania NA.
aDivision of Allergy and Immunology, College of Medicine, University of South Florida, Tampa, Florida bSection of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA.
PURPOSE OF REVIEW: Asthma is a common disease in the older population that is frequently undiagnosed and undertreated. We will review the current knowledge of asthma in the elderly (AIE) and shed light on the diagnostic and management challenges outlining needs for future research.
RECENT FINDINGS: There has been very little original research in the field of AIE published in the last few years, and current literature focuses primarily on a series of review articles. AIE often presents with multiple comorbidities, which complicates its course and management. There is renewed interest in nonallergic (intrinsic) asthma. T helper cell 1 inflammation triggered by respiratory infection, superantigens, proteases and interleukin 17 are possible mechanisms. An association between systemic inflammation in frailty and asthma may also be important.
SUMMARY: The diagnosis and treatment of AIE requires that the individual patient and his or her specific triggers and the likely pathophysiology be understood. Understanding the mechanisms of inflammation in this population is key to improved therapeutic interventions.
Curr Opin Pulm Med. 2009 Oct 19. [Epub ahead of print]
近期发现：过去几年内，AIE领域原创性研究较少，目前文献主要是一些综述性文章。AIE常常与多种疾病并存，因而导致其病程和治疗更为复杂。对于非过敏性哮喘，观点有所更新。呼吸道感染、超抗原、蛋白酶和白介素17引起的T辅助细胞1炎症是其可能的发病机制。系统性炎症与哮喘存在显著相关性。
总结：AIE的诊断和治疗需要对患者的特异性触发因素及可能的病理生理学进行全面了解。对这部分人群炎症机制的研究是改善干预治疗效果的关键步骤。
（ 陈欣 审校）
Curr Opin Pulm Med. 2009 Oct 19. [Epub ahead of print]
Asthma in the elderly: current knowledge and future directions.
King MJ, Hanania NA.
aDivision of Allergy and Immunology, College of Medicine, University of South Florida, Tampa, Florida bSection of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA.
PURPOSE OF REVIEW: Asthma is a common disease in the older population that is frequently undiagnosed and undertreated. We will review the current knowledge of asthma in the elderly (AIE) and shed light on the diagnostic and management challenges outlining needs for future research.
RECENT FINDINGS: There has been very little original research in the field of AIE published in the last few years, and current literature focuses primarily on a series of review articles. AIE often presents with multiple comorbidities, which complicates its course and management. There is renewed interest in nonallergic (intrinsic) asthma. T helper cell 1 inflammation triggered by respiratory infection, superantigens, proteases and interleukin 17 are possible mechanisms. An association between systemic inflammation in frailty and asthma may also be important.
SUMMARY: The diagnosis and treatment of AIE requires that the individual patient and his or her specific triggers and the likely pathophysiology be understood. Understanding the mechanisms of inflammation in this population is key to improved therapeutic interventions.
Curr Opin Pulm Med. 2009 Oct 19. [Epub ahead of print]
上一篇：
儿童哮喘患者加用沙美特罗治疗与氟替卡松剂量加倍治疗比较：一项双盲随机试验(VIAPAED)
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医疗救助人群中的流程质量检测与哮喘恶化的关系
