呼出气一氧化氮分数检测与学龄期儿童变应性致敏相关性最大
2009/11/17
背景：对于儿童早期可以影响呼出气一氧化氮分数（FeNO）的因素尚未完全了解。
目的：本试验旨在儿童中研究FeNO与变应性致敏、总IgE、过敏性皮炎、鼻炎、哮喘和肺功能（肺活量检测）之间的相关性。
方法：根据父母病史，选择刚出生的、具有哮喘和其它过敏性疾病高危因素的儿童参与本项研究，并对其进行前瞻性研究。在儿童6岁和8岁时，通过在线技术检测FeNO。对FeNO与其它过敏性疾病特征和哮喘的相关性进行评价。
结果：6岁时64％（135/210）儿童、8岁时93% （180/194） 的儿童进行了可重复的FeNO检测。FeNO存在季节变异性。在6岁和8岁，存在气源性过敏原致敏的儿童较非致敏儿童FeNO水平增加（几何均数：6岁：10.9 vs 6.7 ppb，P < .0001；8岁, 14.6 vs 7.1 ppb，P < .0001）。8岁时，哮喘患儿较非哮喘患儿FeNO水平高（11.5 vs 9.2 ppb, P = 0.03），但该现象在6岁时未观察到（9.2 vs 8.3 ppb, P = .48）。在包括气源性过敏原致敏在内的多变量模型中，该差异在8岁时不再具有显著性（P = .33）。FeNO与肺活量指标在6岁和8岁时未见显著相关性。
结论：该研究结果强调了将FeNO作为一个潜在的生物标记物，其在诊断和/或监测变应性疾病，尤其是哮喘中评估过敏原致敏状态的重要性。
（陈欣 审校）
J Allergy Clin Immunol. 2009 Sep 11.
Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children.
Jackson DJ, Virnig CM, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Burton RM, Salazar LP, Dasilva DF, Shanovich KM, Tisler CJ, Gern JE, Lemanske RF Jr.
BACKGROUND: Factors affecting fractional exhaled nitric oxide (FeNO) in early childhood are incompletely understood.
OBJECTIVE: To examine the relationships between FeNO and allergic sensitization, total IgE, atopic dermatitis, rhinitis, asthma, and lung function (spirometry) in children.
METHODS: Children at high risk of asthma and other allergic diseases because of parental history were enrolled at birth and followed prospectively. FeNO was measured by an online technique at ages 6 and 8 years. Relationships among FeNO, various atopic characteristics, and asthma were evaluated.
RESULTS: Reproducible FeNO measurements were obtained in 64% (135/210) of 6-year-old and 93% (180/194) of 8-year-old children. There was seasonal variability in FeNO. Children with aeroallergen sensitization at ages 6 and 8 years had increased levels of FeNO compared with those not sensitized (geometric mean; 6 years, 10.9 vs 6.7 parts per billion [ppb], P < .0001; 8 years, 14.6 vs 7.1 ppb, P < .0001). FeNO was higher in children with asthma than in those without asthma at 8 years but not 6 years of age (6 years, 9.2 vs 8.3 ppb, P = .48; 8 years, 11.5 vs 9.2 ppb, P = .03). At 8 years of age, this difference was no longer significant in a multivariate model that included aeroallergen sensitization (P = .33). There were no correlations between FeNO and spirometric indices at 6 or 8 years of age.
CONCLUSION: These findings underscore the importance of evaluating allergen sensitization status when FeNO is used as a potential biomarker in the diagnosis and/or monitoring of atopic diseases, particularly asthma.
J Allergy Clin Immunol. 2009 Sep 11.
目的：本试验旨在儿童中研究FeNO与变应性致敏、总IgE、过敏性皮炎、鼻炎、哮喘和肺功能（肺活量检测）之间的相关性。
方法：根据父母病史，选择刚出生的、具有哮喘和其它过敏性疾病高危因素的儿童参与本项研究，并对其进行前瞻性研究。在儿童6岁和8岁时，通过在线技术检测FeNO。对FeNO与其它过敏性疾病特征和哮喘的相关性进行评价。
结果：6岁时64％（135/210）儿童、8岁时93% （180/194） 的儿童进行了可重复的FeNO检测。FeNO存在季节变异性。在6岁和8岁，存在气源性过敏原致敏的儿童较非致敏儿童FeNO水平增加（几何均数：6岁：10.9 vs 6.7 ppb，P < .0001；8岁, 14.6 vs 7.1 ppb，P < .0001）。8岁时，哮喘患儿较非哮喘患儿FeNO水平高（11.5 vs 9.2 ppb, P = 0.03），但该现象在6岁时未观察到（9.2 vs 8.3 ppb, P = .48）。在包括气源性过敏原致敏在内的多变量模型中，该差异在8岁时不再具有显著性（P = .33）。FeNO与肺活量指标在6岁和8岁时未见显著相关性。
结论：该研究结果强调了将FeNO作为一个潜在的生物标记物，其在诊断和/或监测变应性疾病，尤其是哮喘中评估过敏原致敏状态的重要性。
（陈欣 审校）
J Allergy Clin Immunol. 2009 Sep 11.
Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children.
Jackson DJ, Virnig CM, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Burton RM, Salazar LP, Dasilva DF, Shanovich KM, Tisler CJ, Gern JE, Lemanske RF Jr.
BACKGROUND: Factors affecting fractional exhaled nitric oxide (FeNO) in early childhood are incompletely understood.
OBJECTIVE: To examine the relationships between FeNO and allergic sensitization, total IgE, atopic dermatitis, rhinitis, asthma, and lung function (spirometry) in children.
METHODS: Children at high risk of asthma and other allergic diseases because of parental history were enrolled at birth and followed prospectively. FeNO was measured by an online technique at ages 6 and 8 years. Relationships among FeNO, various atopic characteristics, and asthma were evaluated.
RESULTS: Reproducible FeNO measurements were obtained in 64% (135/210) of 6-year-old and 93% (180/194) of 8-year-old children. There was seasonal variability in FeNO. Children with aeroallergen sensitization at ages 6 and 8 years had increased levels of FeNO compared with those not sensitized (geometric mean; 6 years, 10.9 vs 6.7 parts per billion [ppb], P < .0001; 8 years, 14.6 vs 7.1 ppb, P < .0001). FeNO was higher in children with asthma than in those without asthma at 8 years but not 6 years of age (6 years, 9.2 vs 8.3 ppb, P = .48; 8 years, 11.5 vs 9.2 ppb, P = .03). At 8 years of age, this difference was no longer significant in a multivariate model that included aeroallergen sensitization (P = .33). There were no correlations between FeNO and spirometric indices at 6 or 8 years of age.
CONCLUSION: These findings underscore the importance of evaluating allergen sensitization status when FeNO is used as a potential biomarker in the diagnosis and/or monitoring of atopic diseases, particularly asthma.
J Allergy Clin Immunol. 2009 Sep 11.
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