治疗改善哮喘的长期预后－12年随访研究
2009/10/15
有关支气管哮喘预后的研究目前尚少。本试验通过12年的随访研究确定支气管哮喘的进展及其可能的影响因素。
研究纳入于1989-1993年间（首次评价）163例因支气管哮喘而就诊的门诊患者。并于2003-2005（第二次评价）对患者进行再次评价。两次评价过程中，患者需完成特殊问卷调查，进行皮试和肺量计检测，并接受乙酰甲胆碱激发试验。根据1992年GINA标准将患者按疾病严重程度分为3组：轻度，中度和重度哮喘。
首次评价中，95 (58.3%)例患者诊断为轻度哮喘、45 (27.6%)例为中度哮喘、23 (14.1%)例为重度哮喘。而在第二次评价中，107 (65.6%)例患者诊断为轻度哮喘、44 (27%)例为中度哮喘、12 (7.4%)例为重度哮喘。首次评价显示，哮喘严重程度与男性、年龄较小及无鼻炎相关。第二次评价显示，哮喘严重程度与较大年龄、病程长及吸烟有关。此外，两次评价均显示哮喘与无鼻炎和BHR增加相关。使用吸入糖皮质激素吸入与肺功能改善相关。支气管哮喘的长期预后较好，其预后受到性别（男性）、发病年龄及症状（较早且轻）、无吸烟及鼻炎的影响。
（林江涛审校）
Porpodis K, et al. J Asthma. 2009 Aug; 46(6):625-31.
Long-term prognosis of asthma is good--a 12-year follow-up study. Influence of treatment.
Porpodis K, Papakosta D, Manika K, Kontakiotis T, Gaga M, Sichletidis L, Gioulekas D.
The number of studies on the prognosis of bronchial asthma (BA) is rather limited. The aim of the study was to determine the evolution of BA in a long-term 12-year follow-up and to investigate possible contributing factors. One hundred and sixty-three patients who visited the Out-patient Clinic for BA from 1989 to 1993 (Visit 1) were included in the study. They were re-evaluated during 2003-2005 (Visit 2). At both visits, the patients filled in a special questionnaire, underwent skin tests, spirometry, methacholine challenge and they were classified into three severity groups according to GINA of 1992 as: Mild, Moderate, and Severe asthma. At Visit 1, 95 (58.3%) patients were classified in the mild asthma group, 45 (27.6%) in moderate and 23 (14.1%) in severe; whereas at Visit 2, 107 (65.6%) patients had mild asthma, 44 (27%) moderate and 12 (7.4%) severe. At Visit 1 asthma severity was associated with male gender, younger age, and the absence of rhinitis. At Visit 2 on the other hand, asthma severity was associated with older age, longer duration of disease, smoking and again the absence of rhinitis and increased BHR at both visits. Inhaled corticosteroid use correlated with improvement in lung function. Long-term prognosis of BA was good and outcome was favorably influenced by male gender, early and mild onset of disease, absence of smoking and presence of rhinitis.
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卵清蛋白致敏的豚鼠中吸入孟鲁司特抑制半胱氨酰白三烯诱导的支气管收缩：治疗哮喘的一种潜在新药
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新的磷酸二酯酶3抑制剂NT-702（盐酸帕罗格列，NM-702）通过支气管扩张和抗炎作用抑制豚鼠哮喘
