学龄期哮喘儿童的过敏性鼻炎:诊断和治疗欠佳?一项在儿童医院进行的回顾性研究
2009/09/17
过敏性鼻炎(AR)和哮喘可以认为是同一种疾病的不同临床表现,治疗AR可改善哮喘症状。本试验为在二级儿童医院过敏与哮喘病区中进行的一项回顾性研究,旨在评价哮喘患者中AR的诊断和治疗情况。在903例 7~15岁经医生诊断为哮喘的合格患者中,随机选取了372例入选本研究。其中229例(61.6%, 95% CI: 56.5-66.4%)患者具有AR疑似症状,仅87例患者的病例中记录诊断为AR(23.4%, 95% CI: 19.4-28.0)。研究证实,有AR或鼻部症状的儿童哮喘更为严重。35%的AR患者、23%的有鼻部症状但无AR诊断的患者、和12%无鼻部症状的患者需要吸入糖皮质激素和长效β受体激动剂来治疗哮喘(p = 0.035)。本研究结果显示,对于学龄期的哮喘儿童,AR的诊断和治疗均欠佳。
(陈欣 审校)
Ruokonen M, Kaila M, Haataja R,et al.
Pediatr Allergy Immunol. 2009 Jul 5. [Epub ahead of print]
Allergic rhinitis in school-aged children with asthma - still under-diagnosed and under-treated? A retrospective study in a children’s hospital
Ruokonen M, Kaila M, Haataja R, Korppi M, Paassilta M.
Allergic rhinitis in school-aged children with asthma - still under-diagnosed and under-treated? A retrospective study in a children’s hospital. Pediatr Allergy Immunol 2009. (c) 2009 John Wiley & Sons A/SAllergic rhinitis (AR) and asthma can be considered as manifestations of the same disease entity. The treatment of AR may improve also asthma symptoms. The aim of the study was to evaluate, how often AR is diagnosed and treated in patients with asthma. A retrospective chart review in the allergy and asthma unit of a secondary paediatric hospital. From 903 eligible 7- to 15-year-old children with doctor-diagnosed asthma, 372 were randomly included in the study. In all, 229 patients (61.6%, 95% CI: 56.5-66.4%) had symptoms presumptive for AR. The diagnosis of AR was recorded in the patient records only for 87 patients (23.4%, 95% CI: 19.4-28.0). There was evidence that children with AR or nasal symptoms had more severe asthma; 35% of the patients with AR, 23% with nasal symptoms without AR diagnosis and 12% without nasal symptoms required inhaled steroids and long-acting beta-agonists for asthma (p = 0.035). AR was both under-diagnosed and under-treated in school-aged children with doctor-diagnosed asthma.
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吸入四倍剂量性糖皮质激素预防哮喘恶化:一项随机、双盲、安慰剂对照、平行分组临床试验
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沙美特罗和丙酸氟替卡松联合治疗以及丙酸氟替卡松单独治疗对轻症哮喘患者气道功能和嗜酸性粒细胞性炎症反应