成人支气管扩张患者的不同表型：儿童和成人排痰性咳嗽的发作
2009/06/24
支气管扩张为异质性疾病，病因较多。主要症状为慢性排痰性咳嗽。本试验主要描述儿童期（16岁前）和成人期出现慢性排痰性咳嗽的支气管扩张患者的表型。经过CT扫描诊断的182名支气管扩张患者入选本项研究。回顾所有患者的病史，并对潜在病因进行分析。107名（59％）患者儿童时期就存在排痰性咳嗽，75名（41％）患者在成人后才出现排痰性咳嗽。在咳嗽时间、加重频率、鼻炎及鼻窦炎、体检时捻发音及肺功能上两组患者存在显著差异。成人组还可细分为与吸烟相关咳嗽组和吸烟无关咳嗽组。
结论：儿童期或成人期出现排痰性咳嗽的患者之间存在诸多差异，两者反应了支气管扩张症的不同表型。
（刘国梁 审校）
King PT, et al. COPD. 2009 Apr;6(2):130-136.
Phenotypes of adult bronchiectasis: onset of productive cough in childhood and adulthood.
Bronchiectasis is a heterogeneous disorder with a large number of etiologic factors. The main symptom is a chronic productive cough. The aim of this study was to describe the phenotypes of patients with bronchiectasis who had developed a chronic productive cough in childhood (before 16 years of age) compared with those who had developed a productive cough as adults. One hundred and eighty-two subjects with bronchiectasis diagnosed by computed tomography scanning were studied. Subjects all had a detailed clinical review and assessment of potential etiologic factors performed by the investigators. There were 107 (59%) subjects who developed a chronic productive cough in childhood and 75 (41%) subjects who developed a chronic productive cough in adulthood. There were significant differences in a number of parameters between the two groups including duration of cough, frequency of exacerbations, presence of rhinosinusitis, crackles on examination and lung function. The adult group could be further divided into those who had developed a cough whilst smoking and those who had no obvious relationship with smoking. In conclusion there were a number of significant differences between the child onset and adult onset group that may reflect different phenotypes of bronchiectasis.
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肺科专家和执业呼吸病教育专家对慢性咳嗽患者进行的处理对患者生活质量的影响：随机试验
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囊性肺纤维化成人中咳嗽的诊断及对胃底折叠术的反应
