传统中药治疗哮喘和过敏症的有效性及其机制
2009/05/13
背景：虽然糖皮质激素和β 2-受体激动剂能有效控制哮喘症状，但很少能治愈。传统中药（TCM）在亚洲已经使用了数百年，作为一个候选或补充医疗模式，其在西方卫生保健中也发挥了较大作用。支持传统中药治疗哮喘的证据也在不断增加。
目的：本综述探讨了中药对哮喘干预的疗效及其可能机制。
方法：我们首先分析了2005～2007年发表的文章中抗哮喘中草药研究的5个临床试验。然后基于出版的论著、摘要以及可获得的数据库，总结了其治疗的潜在机制。这些可能的机制包括：抗炎、抑制气道平滑肌收缩和免疫调节作用。对于中草药治疗食物过敏的研究较少，因此，我们在鼠类花生过敏模型中集中研究食物过敏中药配方-2的疗效及其治疗机制，探讨了其初期临床结果。
结论：临床证据支持TCM在哮喘中的治疗作用。治疗的机制可能有多种。强有力的临床前研究数据显示，食物过敏中药配方-2具有潜在治疗食物过敏的作用。
（苏楠 审校）
Li XM, Brown L. J Allergy Clin Immunol. 2009 Feb;123(2):297-306
Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy.
BACKGROUND: Although corticosteroids and beta(2)-agonists are effective in managing asthma symptoms, a curative therapy for asthma is lacking. Traditional Chinese medicine (TCM), used in Asia for centuries, is beginning to play a role in Western health care as a complementary and alternative medicine modality. There is increasing scientific evidence supporting the use of TCM for asthma treatment.
OBJECTIVE: This review article discusses promising TCM interventions for asthma and explores their possible mechanisms of action.
METHODS: We first reviewed 5 clinical studies of antiasthma TCM herbal remedies published between 2005 and 2007. We then summarized possible mechanisms underlying their effects on the basis of data in the original articles, published abstracts, and available databases. Possible mechanisms include anti-inflammation, inhibition of airway smooth muscle contraction, and immunomodulation. Research on TCM herbal therapy for food allergy is rare, and we therefore focused on the effect and mechanism of action of food allergy herbal formula-2 on a murine model of peanut allergy and preliminary clinical study results.
CONCLUSION: Evidence from clinical studies supports beneficial effects of TCM herbal therapy on asthma. A number of mechanisms may be responsible for efficacy of these agents. Strong preclinical study data suggest the potential efficacy of food allergy herbal formula-2 for food allergy.
上一篇：
目前治疗过敏性鼻炎和支气管哮喘的免疫学方法
下一篇：
吸入糖皮质激素在复发喘息和哮喘的婴儿及学龄前儿童中的疗效：荟萃分析的系统综述
