莱斯特咳嗽问卷在调查非囊性纤维化支气管扩张症患者中的有效性
2009/05/20
健康相关的生命质量是评价已有和新的支气管扩张治疗有效性的重要标志。莱斯特咳嗽问卷调查（LCQ）是为评价咳嗽严重程度对机体的影响而设计的症状特异性问卷调查表。
本试验研究LCQ在调查支气管扩张症患者中的有效性。LCQ的有效性、反应性和可靠性通过以下指标评价：能够鉴别疾病的严重程度；疾病恶化后采用抗生素治疗，调查表能体现出患者评分的变化；在疾病稳定期6个月内，该调查具有可重复性；与St George呼吸性疾病问卷调查（SGRQ）相比较。120名患者（严重、中度和轻度支气管扩张症患者分别为51、29和40名）完成LCQ和SGRQ调查表。2周抗生素治疗后，LCQ评分得到改善，从11.3(9.3-13.7)上升到17.8(15-18.8) (P<0.0001)。LCQ评分在6个月的疾病稳定期内具有可重复性[组内相关系数0.96 (95%CI 0.93-0.97), P<0.0001]。在疾病稳定期和恶化期，LCQ和SGRQ评分相关性为-0.7(P<0.0001)。LCQ能区分疾病的严重程度，对变化能产生反应，能在非囊性纤维化性支气管扩张症中应用。
（林江涛 审校）
Murray MP, et al. Eur Respir J. 2009 Feb 5. [Epub ahead of print]
Validation of the Leicester Cough Questionnaire in Non Cystic Fibrosis Bronchiectasis.
Health related quality of life is a potentially important marker for evaluating existing and new therapies in bronchiectasis. The Leicester Cough Questionnaire (LCQ) is a symptom specific questionnaire designed to assess the impact of cough severity, a major symptom of bronchiectasis. This study aimed to validate the LCQ in bronchiectasis. The validity, responsiveness and reliability of the LCQ was assessed: ability to discriminate severe and mild disease; change in score following antibiotic treatment for exacerbations; repeatability over a 6 month period in stable disease; comparison with the St George’s Respiratory Questionnaire (SGRQ).120 patients (51 with severe disease, 29 with moderate and 40 with mild) completed the LCQ and SGRQ. The area under the receiver-operator curve was good for both severe and mild disease (0.84 and 0.80 respectively, P<0.0001). Following 2 weeks’ antibiotic treatment, the LCQ score improved from 11.3(9.3-13.7) to 17.8(15-18.8) (P<0.0001). The LCQ score was repeatable over 6 months in stable disease [intraclass correlation coefficient of 0.96 (95%CI 0.93-0.97), P<0.0001]. Correlation between the LCQ and SGRQ scores was -0.7 in both stable disease and exacerbations (P<0.0001).The LCQ can discriminate disease severity, is responsive to change and is reliable for use in non-cystic fibrosis bronchiectasis.
