妊娠期间母体食物摄取与儿童期哮喘发展的关系
2008/09/28
妊娠期间母体的食物摄入可潜在影响胎儿的气道发展及Th2细胞反应，最终可能增加儿童期哮喘和过敏症的风险。
荷兰学者对4146名妊娠妇女进行观察随访，记录妊娠最后1个月内水果、蔬菜、鱼、蛋、奶、奶产品及坚果产品的摄入频率，并对之后出生的孩子随访至8岁，分析儿童哮喘结果与上述食物摄入的关系。最终共获得2832名儿童的完整数据。结果发现：每日摄入坚果类产品可增加儿童时期喘息、呼吸困难、皮质醇使用及哮喘症状的风险性。
学者认为，这一研究提示母体妊娠期间经常摄入坚果类产品可提高儿童时期哮喘风险，但在将之作为妊娠饮食建议告知孕妇前仍需要更多研究加以证实。
（农英 卫生部中日友好医院呼吸内科 100029 摘译）
（Am J Respir Crit Care Med. 2008 ;178(2):124-31.）
Maternal food consumption during pregnancy and the longitudinal development of childhood asthma.
Willers SM, Wijga AH, Brunekreef B, Kerkhof M, Gerritsen J, Hoekstra MO, de Jongste JC, Smit HA.
Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, P.O. Box 80178, 3508 TD Utrecht, The Netherlands. s.m.willers@uu.nl
RATIONALE: Maternal diet during pregnancy has the potential to affect airway development and to promote T-helper-2-cell responses during fetal life. This might increase the risk of developing childhood asthma or allergy. OBJECTIVES: We investigated the influence of maternal food consumption during pregnancy on childhood asthma outcomes from 1 to 8 years of age.
METHODS: A birth cohort study consisting of a baseline of 4,146 pregnant women (1,327 atopic and 2,819 nonatopic). These women were asked about their frequency of consumption of fruit, vegetables, fish, egg, milk, milk products, nuts, and nut products during the last month. Their children were followed until 8 years of age. Longitudinal analyses were conducted to assess associations between maternal diet during pregnancy and childhood asthma outcomes over 8 years.
MEASUREMENTS AND MAIN RESULTS: Complete data were obtained for 2,832 children. There were no associations between maternal vegetable, fish, egg, milk or milk products, and nut consumption and longitudinal childhood outcomes. Daily consumption of nut products increased the risk of childhood wheeze (odds ratio [OR] daily versus rare consumption, 1.42; 95% confidence interval [95% CI], 1.06-1.89), dyspnea (OR, 1.58; 95% CI, 1.16-2.15), steroid use (OR, 1.62; 95% CI, 1.06-2.46), and asthma symptoms (OR, 1.47; 95% CI, 1.08-1.99).
CONCLUSIONS: Results of this study indicate an increased risk of daily versus rare consumption of nut products during pregnancy on childhood asthma outcomes. These findings need to be replicated by other studies before dietary advice can be given to pregnant women.
METHODS: A birth cohort study consisting of a baseline of 4,146 pregnant women (1,327 atopic and 2,819 nonatopic). These women were asked about their frequency of consumption of fruit, vegetables, fish, egg, milk, milk products, nuts, and nut products during the last month. Their children were followed until 8 years of age. Longitudinal analyses were conducted to assess associations between maternal diet during pregnancy and childhood asthma outcomes over 8 years.
MEASUREMENTS AND MAIN RESULTS: Complete data were obtained for 2,832 children. There were no associations between maternal vegetable, fish, egg, milk or milk products, and nut consumption and longitudinal childhood outcomes. Daily consumption of nut products increased the risk of childhood wheeze (odds ratio [OR] daily versus rare consumption, 1.42; 95% confidence interval [95% CI], 1.06-1.89), dyspnea (OR, 1.58; 95% CI, 1.16-2.15), steroid use (OR, 1.62; 95% CI, 1.06-2.46), and asthma symptoms (OR, 1.47; 95% CI, 1.08-1.99).
CONCLUSIONS: Results of this study indicate an increased risk of daily versus rare consumption of nut products during pregnancy on childhood asthma outcomes. These findings need to be replicated by other studies before dietary advice can be given to pregnant women.
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季节和温度对碳元素空气污染与儿童哮喘急诊增加之间关系的影响
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