目前减少尘螨暴露的物理和/或化学方法，并不能有效改善过敏性哮喘患者呼吸功能，减少哮喘发作及用药
2008/08/13
丹麦哥本哈根北欧Cochrane医学数据研究中心 Gotzche PC及 Johansen HK，通过对54个临床研究的荟萃分析，研究了减少尘螨接触与暴露的物理或/及化学方法对尘螨过敏的哮喘患者肺功能、哮喘症状评分及平喘治疗用药的影响，发现目前控制尘螨暴露的物理和/或化学手段，并不能有效减少哮喘发作、用药及改善肺功能，因此不作推荐。
编译者注：控制尘螨暴露的物理或化学的手段诸如防螨床罩、各种除螨剂等。
（蔡闯 广州医学院第一附属医院 广州呼吸疾病研究所 510120 摘译）
（Allergy. 2008；63:646-659 ）
House dust mite control measures for asthma: systematic review
Gotzche PC, Johansen HK
Abstract 摘要
The major allergen in house dust comes from mites. We performed a systematic review of the randomized trials that had assessed the effects of reducing exposure to house dust mite antigens in the homes of people with mite-sensitive asthma, and had compared active interventions with placebo or no treatment. Fifty-four trials (3002 patients) were included. Thirty-six trials assessed physical methods (26 mattress covers), 10 chemical methods and eight a combination of chemical and physical methods. Despite the fact that many trials were of poor quality and would be expected to exaggerate the reported effect, we did not find an effect of the interventions. For the most frequently reported outcome, peak flow in the morning (1565 patients), the standardized mean difference was 0.00 (95% confidence interval (CI) -0.10 to 0.10). There were no statistically significant differences in number of patients improved (relative risk 1.01, 95% CI 0.80-1.27), asthma symptom scores (standardized mean difference -0.04, 95% CI -0.15 to 0.07) or in medication usage (standardized mean difference -0.06, 95% CI -0.18 to 0.07). Chemical and physical methods aimed at reducing exposure to house dust mite allergens cannot be recommended.
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