哮喘和COPD的免疫机制
2008/08/13
英国心肺研究所Peter J Barnes教授的综述：“哮喘和COPD的免疫机制 ”。 该文图文并茂，系统总结了哮喘和COPD 分子免疫学领域的最新进展，着重比较了参与（外源性）哮喘和COPD的气道炎症的炎细胞、炎性介质的异同以及大、小气道、肺实质的不同病理表现；在以上认识的基础上，探讨了哮喘和COPD治疗策略和研究发展方向。
（蔡闯 广州医学院第一附属医院 广州呼吸疾病研究所 510120 摘译）
（Nature reviews/immunology, 2008; 8:183-192）
Immunology of asthma and chronic obstructive pulmonary disease
Barnes PJ
Abstract 摘要
Asthma and chronic obstructive pulmonary disease (COPD) are both obstructive airway diseases that involve chronic inflammation of the respiratory tract, but the type of inflammation is markedly different between these diseases, with different patterns of inflammatory cells and mediators being involved. As described in this Review, these inflammatory profiles are largely determined by the involvement of different immune cells, which orchestrate the recruitment and activation of inflammatory cells that drive the distinct patterns of structural changes in these diseases. However, it is now becoming clear that the distinction between these diseases becomes blurred in patients with severe asthma, in asthmatic subjects who smoke and during acute exacerbations. This has important implications for the development of new therapies.
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腺苷-5-磷酸对哮喘的作用：气体交换和痰液细胞学反应
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