气道平滑肌是调整哮喘气道炎症“缺失的环节”吗？
2008/06/06
众所周知，气道平滑肌（ASM）在哮喘患者的支气管肌紧张性中起着重要的调节作用，一些新的实验或调查数据也指出了ASM在气道炎症反应中所起到的作用。Tliba O等人的综述对ASM的免疫调节机能以及利用此原理对哮喘的治疗中的作用进行了详细的阐述，为广大对ASM有所研究的医师提供引导。
（于娜 中国医科大学附属第一医院呼吸内科 110001 摘择）
（Chest. 2008 Jan;133(1):236-242.）
Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?
Tliba O, Amrani Y, Panettieri RA Jr.
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 125 South 31st St, Philadelphia, PA 19104-3403, USA. omartlib@mail.med.upenn.edu
Airway smooth muscle (ASM) plays a central role in regulating bronchomotor tone in patients with asthma. New evidence, however, suggests that ASM may also orchestrate and perpetuate airway inflammation by promoting the recruitment, activation, and trafficking of inflammatory cells in the airways. This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma.
Chest. 2008 Jan;133(1):236-42. Links
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中重度哮喘患者气道细胞因子表达的差异性比较
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长期使用β受体阻滞剂减轻小鼠哮喘模型气道炎症和粘蛋白含量
