哮喘患者血浆磷脂酶A2的活性与体重指数及血浆胆固醇浓度相关性分析
2008/06/06
分泌型磷脂酶A2(sPLA2)与哮喘气道炎症程度相关，它参与调节类花生酸合成、影响树突状细胞及T细胞功能。最近发表于Thorax上的一篇报道，通过测定哮喘患者稳定期及急性发作期sPLA2的活性，评价了sPLA2与体重指数(BMI)、血浆胆固醇以及维生素C浓度之间的相关关系。该研究发现，尽管急性发作期哮喘患者sPLA2活性增强，但重度哮喘患者sPLA2活性没有明显增加；性别与血浆胆固醇、血浆维生素C之间的相关性与sPLA2的活性有关。
借此，他们认为血浆sPLA2可能是哮喘、炎症、脂代谢、抗氧化等病理生理过程中的一个生物链接点。这些因素的相互作用可能参与哮喘及肥胖的发生。
（毛辉 四川大学华西医院呼吸科610041 摘译）
(Thorax. 2008 Jan;63(1):21-26. Epub 2007 Jun 15. Links)
Plasma phospholipase A2 activity in patients with asthma: association with body mass index and cholesterol concentration.
Misso NL, Petrovic N, Grove C, Celenza A, Brooks-Wildhaber J, Thompson PJ.
Lung Institute of Western Australia (Inc.), Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, Australia. nmisso@liwa.uwa.edu.au
BACKGROUND: Secretory phospholipases A2 (sPLA2) have functions relevant to asthmatic inflammation, including eicosanoid synthesis and effects on dendritic cells and T cells. The aim of this study was to measure sPLA2 activity in patients with stable and acute asthma and to assess potential associations with body mass index (BMI), and plasma cholesterol and vitamin C concentrations.
METHODS: Plasma sPLA2 activity and concentrations of cholesterol and vitamin C were measured in 23 control subjects and 61 subjects with stable asthma (42 mild to moderate, 19 severe). In addition, sPLA2 activity was measured in 36 patients experiencing acute asthma and in 22 of these patients after recovery from the acute attack.
RESULTS: sPLA2 activity was not significantly greater in severe (499.9 U; 95% confidence interval (CI) 439.4 to 560.4) compared with mild to moderate asthmatic subjects (464.8; 95% CI 425.3 to 504.3) or control subjects (445.7; 95% CI 392.1 to 499.4), although it was higher in patients with acute asthma (581.6; 95% CI 541.2 to 622.0; p<0.001). Male gender, high plasma cholesterol, increased BMI and atopy were associated with increased sPLA2 activity, while plasma vitamin C was inversely correlated with sPLA2 activity in patients with stable asthma and in control subjects. There were significant interactions between gender and plasma cholesterol and between gender and vitamin C in relation to sPLA2 activity.
CONCLUSIONS: Plasma sPLA2 may provide a biological link between asthma, inflammation, increased BMI, lipid metabolism and antioxidants. Interactions among these factors may be pertinent to the pathophysiology and increasing prevalence of both asthma and obesity.
Thorax. 2008 Jan;63(1):21-6. Epub 2007 Jun 15. Links
借此，他们认为血浆sPLA2可能是哮喘、炎症、脂代谢、抗氧化等病理生理过程中的一个生物链接点。这些因素的相互作用可能参与哮喘及肥胖的发生。
（毛辉 四川大学华西医院呼吸科610041 摘译）
(Thorax. 2008 Jan;63(1):21-26. Epub 2007 Jun 15. Links)
Plasma phospholipase A2 activity in patients with asthma: association with body mass index and cholesterol concentration.
Misso NL, Petrovic N, Grove C, Celenza A, Brooks-Wildhaber J, Thompson PJ.
Lung Institute of Western Australia (Inc.), Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, Australia. nmisso@liwa.uwa.edu.au
BACKGROUND: Secretory phospholipases A2 (sPLA2) have functions relevant to asthmatic inflammation, including eicosanoid synthesis and effects on dendritic cells and T cells. The aim of this study was to measure sPLA2 activity in patients with stable and acute asthma and to assess potential associations with body mass index (BMI), and plasma cholesterol and vitamin C concentrations.
METHODS: Plasma sPLA2 activity and concentrations of cholesterol and vitamin C were measured in 23 control subjects and 61 subjects with stable asthma (42 mild to moderate, 19 severe). In addition, sPLA2 activity was measured in 36 patients experiencing acute asthma and in 22 of these patients after recovery from the acute attack.
RESULTS: sPLA2 activity was not significantly greater in severe (499.9 U; 95% confidence interval (CI) 439.4 to 560.4) compared with mild to moderate asthmatic subjects (464.8; 95% CI 425.3 to 504.3) or control subjects (445.7; 95% CI 392.1 to 499.4), although it was higher in patients with acute asthma (581.6; 95% CI 541.2 to 622.0; p<0.001). Male gender, high plasma cholesterol, increased BMI and atopy were associated with increased sPLA2 activity, while plasma vitamin C was inversely correlated with sPLA2 activity in patients with stable asthma and in control subjects. There were significant interactions between gender and plasma cholesterol and between gender and vitamin C in relation to sPLA2 activity.
CONCLUSIONS: Plasma sPLA2 may provide a biological link between asthma, inflammation, increased BMI, lipid metabolism and antioxidants. Interactions among these factors may be pertinent to the pathophysiology and increasing prevalence of both asthma and obesity.
Thorax. 2008 Jan;63(1):21-6. Epub 2007 Jun 15. Links
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甲壳质酶样蛋白在哮喘患者肺及循环中含量
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伴或不伴阿司匹林过敏的哮喘患者前列腺素E2生成情况
