超重、肥胖对哮喘发病风险的影响
2007/08/01
Beuther DA等采用meta分析方法分析了体重指数（BMI）与成人哮喘发病的相关性及性别对这种相关性的影响。
作者从网上文献数据库中收集评估BMI与成人哮喘发病相关性的前瞻性研究报道，纳入分析的文献均以BMI < 25为正常体重，BMI 25-29.9为超重，BMI >= 30为肥胖，且以观察期内每年新发哮喘率为观察指标。分析结果表明，与正常体重者相比，超重和肥胖者总的哮喘发生的风险显著增加（优势比为1.51，95%可信区间为1.27～1.80）。而肥胖者的哮喘发生风险比超重者又更为严重，与正常者相比的优势比分别为1.92和1.38。对不同性别单独进行分析发现，无论男性或女性，超重和肥胖者的哮喘发生风险均明显增加，优势比分别为1.46（95%可信区间为1.05～2.02）和1.68（95%可信区间为1.45～1.94）。
因此作者认为无论男性女性，超重或肥胖均可增加哮喘发生风险，而且BMI越高发生风险越大。从而提示可通过控制体重来降低哮喘发生率。
（王苹莉 浙江大学医学院附属二院呼吸内科 310009 摘译）
(Am J Respir Crit Care Med. 2007 ;175:661-666)
Beuther DA, Sutherland ER.Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007 Apr 1;175(7):661-6
RATIONALE: Although obesity has been implicated as an asthma risk factor, there is heterogeneity in the published literature regarding its role in asthma incidence, particularly in men.
OBJECTIVES: To quantify the relationship between categories of body mass index (BMI) and incident asthma in adults and to evaluate the impact of sex on this relationship.
METHODS: Online bibliographic databases were searched for prospective studies evaluating BMI and incident asthma in adults. Independent observers extracted data regarding annualized asthma incidence from studies meeting predetermined criteria, within defined categories of normal weight (BMI < 25), overweight (BMI, 25-29.9), and obesity (BMI >or= 30). Data were analyzed by inverse-variance-weighted, random-effects meta-analysis. Stratified analysis between BMI categories and within sex was performed.
RESULTS: Seven studies (n=333,102 subjects) met inclusion criteria. Compared with normal weight, overweight and obesity (BMI >or= 25) conferred increased odds of incident asthma, with an odds ratio (OR) of 1.51 (95%confidence interval [CI], 1.27-1.80). A dose-response effect of elevated BMI on asthma incidence was observed; the OR for incident asthma for normal-weight versus overweight subjects was 1.38 (95% CI, 1.17-1.62) and was further elevated for normal weight versus obesity (OR, 1.92; 95% CI, 1.43-2.59; p<0.0001 for the trend). A similar increase in the OR of incident asthma due to overweight and obesity was observed in men (OR, 1.46; 95% CI, 1.05-2.02) and women (OR, 1.68; 95% CI, 1.45-1.94; p=0.232 for the comparison).
CONCLUSIONS: Overweight and obesity are associated with a dose-dependent increase in the odds of incident asthma in men and women, suggesting asthma incidence could be reduced by interventions targeting overweight and obesity
上一篇：
哮喘及其严重度的评分揭示了新的基因关联位点
下一篇：
支气管哮喘的流行病学
