复吸后持续使用尼古丁贴剂能促进戒断
2012/02/29
目的：戒烟后复吸的吸烟者其复吸的风险显著增加，因此，有必要采取措施促进复吸后的戒断。2项近期研究显示，复吸后持续使用尼古丁贴剂有助于预防复吸。然而，目前尚未有研究在现实生活中采用认可剂量的尼古丁贴剂来验证该假设。
设计和参与机构：本研究为在美国8个临床机构实施的临床试验。
参与者和检测指标：数据来自于509名戒烟治疗3～5周后的复吸者（240名尼古丁贴剂使用者，269名安慰剂组）。本试验为随机、双盲、安慰剂对照试验，采用21-mg尼古丁贴剂，研究尼古丁贴剂使用能否改善6周和10周时的7天点戒断率。
结果：与安慰剂组相比，尼古丁贴剂能显著增加6周（8.3% vs 0.8%，相对危险度=11.0，P<0.001）和10周（9.6% vs 2.6%，相对危险度=3.7，P<0.001）时的戒断。
结论：持续尼古丁贴剂戒烟，能有效增加戒断率。若吸烟者出现复吸，应该鼓励吸烟者持续使用尼古丁贴剂。
设计和参与机构：本研究为在美国8个临床机构实施的临床试验。
参与者和检测指标：数据来自于509名戒烟治疗3～5周后的复吸者（240名尼古丁贴剂使用者，269名安慰剂组）。本试验为随机、双盲、安慰剂对照试验，采用21-mg尼古丁贴剂，研究尼古丁贴剂使用能否改善6周和10周时的7天点戒断率。
结果：与安慰剂组相比，尼古丁贴剂能显著增加6周（8.3% vs 0.8%，相对危险度=11.0，P<0.001）和10周（9.6% vs 2.6%，相对危险度=3.7，P<0.001）时的戒断。
结论：持续尼古丁贴剂戒烟，能有效增加戒断率。若吸烟者出现复吸，应该鼓励吸烟者持续使用尼古丁贴剂。
（陈欣 审校）
Addiction. 2012 Jan 26. doi: 10.1111/j.1360-0443.2012.03801.x. [Epub ahead of print]
Addiction. 2012 Jan 26. doi: 10.1111/j.1360-0443.2012.03801.x. [Epub ahead of print]
Source
School of Pharmacy and Menzies Research Institute Tasmania, University of Tasmania, Hobart, TAS, Australia; Pinney Associates, Inc., Bethesda, MD, USA, Pinney Associates, Inc., Pittsburgh, PA, USA; University of Pittsburgh, Pittsburgh, PA, USA.
School of Pharmacy and Menzies Research Institute Tasmania, University of Tasmania, Hobart, TAS, Australia; Pinney Associates, Inc., Bethesda, MD, USA, Pinney Associates, Inc., Pittsburgh, PA, USA; University of Pittsburgh, Pittsburgh, PA, USA.
Abstract
AIMS: Smokers who lapse during a cessation attempt are at particularly high risk of relapse, so interventions to help smokers recover from lapses are urgently needed. Two recent studies have suggested continuing to use nicotine patches following a lapse may be a beneficial relapse prevention strategy. However, to date no study that uses approved doses of nicotine patches under real-world conditions has tested this hypothesis.
DESIGN & SETTING: Clinical trial conducted across eight US study sites.
PARTICIPANTS & MEASUREMENTS: Using data from 509 subjects (240 active; 269 placebo) who lapsed during weeks 3-5 of treatment in a randomized, double blind placebo controlled trial of 21-mg nicotine patches, we examined whether active nicotine patch use improved the chances of recovering abstinence (7-day point-prevalence) at weeks 6 and 10.
FINDINGS: Active patch use (versus placebo) increased the likelihood of recovery from a lapse both at 6 weeks (8.3% vs 0.8%; Relative Risk [RR]=11.0, p<.001) and at 10 weeks (9.6% vs 2.6%; RR=3.7, p<.001).
CONCLUSIONS: Continuing treatment to aid smoking cessation with active patches promotes recovery from lapses. Smokers should be encouraged to persist with patch treatment if they lapse to smoking.
Addiction. 2012 Jan 26. doi: 10.1111/j.1360-0443.2012.03801.x. [Epub ahead of print]
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轻度吸烟的非洲裔美国人中采用安非他酮戒烟：随机对照试验
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尼古丁替代治疗用于减少吸烟和暂时戒断：访谈研究
