戒烟后体重增加和空腹血糖异常
2011/11/21
摘要
背景：戒烟后体重增加，可导致空腹血糖变化。对空腹血糖变化的早期监测，有助于预测糖尿病（DM）和空腹血糖异常（IFG）。本试验旨在研究戒烟后体重增加对高空腹血糖(IFG) (≥100 mg/dL)风险早期变化的影响。
方法：选择946例戒烟后经常体检的受试者。检测体重指数（BMI），计算戒烟后每年的IFG风险优势比（OR）（对性别、年龄、BMI、1年时空腹血糖和饮酒等因素进行调整），连续检测3年。
结果：戒烟后，受试者BMI率显著增加：第2年时为2.36%（从不吸烟者：0.22%；当前吸烟者：0.39%），第3年为0.46%（从不吸烟者：0.14%；当前吸烟者：0.32%）。然而，在第4年，降至0.15%（从不吸烟者：0.12%；当前吸烟者：0.26%）。戒烟者的OR值在随访期内并未显著增加。然而，对于每天吸烟至少20支的戒烟者，优势比更高（OR：1.51, 95%CI：1.1-2.01[1 年]; 1.71, 1.23-2.38 [2年]）。
结论：戒烟后IFG风险的变化时程与BMI率增加的时程相似。与以往研究不同的是，戒烟后IFG风险只出现短暂升高，消失时BMI并无显著增加。
背景：戒烟后体重增加，可导致空腹血糖变化。对空腹血糖变化的早期监测，有助于预测糖尿病（DM）和空腹血糖异常（IFG）。本试验旨在研究戒烟后体重增加对高空腹血糖(IFG) (≥100 mg/dL)风险早期变化的影响。
方法：选择946例戒烟后经常体检的受试者。检测体重指数（BMI），计算戒烟后每年的IFG风险优势比（OR）（对性别、年龄、BMI、1年时空腹血糖和饮酒等因素进行调整），连续检测3年。
结果：戒烟后，受试者BMI率显著增加：第2年时为2.36%（从不吸烟者：0.22%；当前吸烟者：0.39%），第3年为0.46%（从不吸烟者：0.14%；当前吸烟者：0.32%）。然而，在第4年，降至0.15%（从不吸烟者：0.12%；当前吸烟者：0.26%）。戒烟者的OR值在随访期内并未显著增加。然而，对于每天吸烟至少20支的戒烟者，优势比更高（OR：1.51, 95%CI：1.1-2.01[1 年]; 1.71, 1.23-2.38 [2年]）。
结论：戒烟后IFG风险的变化时程与BMI率增加的时程相似。与以往研究不同的是，戒烟后IFG风险只出现短暂升高，消失时BMI并无显著增加。
（陈欣 审校）
J Epidemiol. 2011 Oct 15. [Epub ahead of print]
J Epidemiol. 2011 Oct 15. [Epub ahead of print]
Source
Department of Occupational Health, Kanagawa Health Service Association.
Department of Occupational Health, Kanagawa Health Service Association.
Abstract
BACKGROUND: Observation of early changes in fasting plasma glucose level induced by post-smoking cessation weight gain is useful in predicting the risks of diabetes mellitus (DM) and impaired fasting glucose (IFG). We investigated the effect of post-smoking cessation weight gain on early changes in the risk of a high fasting plasma glucose (IFG) level (≥100 mg/dL).
METHODS: In 946 subjects who underwent repeated health examinations after smoking cessation, changes in body mass index (BMI) and the odds ratio (OR) for IFG risk (adjusted for sex, age, BMI, fasting plasma glucose at year 1, and alcohol consumption) were calculated every year for 3 years after smoking cessation.
RESULTS: After smoking cessation, the rate of BMI increase significantly increased in quitters: 2.36% at year 2 (never smokers: 0.22%, current smokers: 0.39%) and 0.46% at year 3 (never smokers: 0.14%, current smokers: 0.32%). However, it decreased by 0.15% at year 4 (never smokers: 0.12%, current smokers: 0.26%). The ORs for quitters did not significantly increase at any time during the follow-up period. However, among quitters who had smoked at least 20 cigarettes per day, it was significantly higher (OR 1.51, 95% confidence interval 1.1-2.01 at year 1 and 1.71, 1.23-2.38 at year 2).
CONCLUSIONS: The time course of the risk of IFG after smoking cessation was similar to that for the rate of BMI increase. In contrast to the findings of previous reports, the increase in IFG risk after smoking cessation was brief and disappeared in the absence of a significant increase in BMI.
BACKGROUND: Observation of early changes in fasting plasma glucose level induced by post-smoking cessation weight gain is useful in predicting the risks of diabetes mellitus (DM) and impaired fasting glucose (IFG). We investigated the effect of post-smoking cessation weight gain on early changes in the risk of a high fasting plasma glucose (IFG) level (≥100 mg/dL).
METHODS: In 946 subjects who underwent repeated health examinations after smoking cessation, changes in body mass index (BMI) and the odds ratio (OR) for IFG risk (adjusted for sex, age, BMI, fasting plasma glucose at year 1, and alcohol consumption) were calculated every year for 3 years after smoking cessation.
RESULTS: After smoking cessation, the rate of BMI increase significantly increased in quitters: 2.36% at year 2 (never smokers: 0.22%, current smokers: 0.39%) and 0.46% at year 3 (never smokers: 0.14%, current smokers: 0.32%). However, it decreased by 0.15% at year 4 (never smokers: 0.12%, current smokers: 0.26%). The ORs for quitters did not significantly increase at any time during the follow-up period. However, among quitters who had smoked at least 20 cigarettes per day, it was significantly higher (OR 1.51, 95% confidence interval 1.1-2.01 at year 1 and 1.71, 1.23-2.38 at year 2).
CONCLUSIONS: The time course of the risk of IFG after smoking cessation was similar to that for the rate of BMI increase. In contrast to the findings of previous reports, the increase in IFG risk after smoking cessation was brief and disappeared in the absence of a significant increase in BMI.
J Epidemiol. 2011 Oct 15. [Epub ahead of print]
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