肺癌CT筛查结果对戒烟的影响
2011/07/06
摘要
肺癌CT筛查结果可能对戒烟有所帮助，但有时有可能不故意的让吸烟者继续吸烟。本试验旨在荷兰比利时随机对照肺癌筛查（NELSON）试验中研究筛查结果是否与戒烟相关。随机选取有阴性检查结果(n=550)和一项或多项检查结果不确定(n=440)的男性吸烟者，随机分组后2年采用问卷调查。有不确定结果的吸烟者中，更多的吸烟者主诉有戒烟意愿(p=0.02)，但两组吸烟者，在长期戒断率上相似（分别为8.9%; 46/519；11.5%; 48/419；(p=0.19)）。与检查结果为阴性的吸烟者相比(8.9%)，有1项（10.9%）或多项（15.0%）不确定结果的吸烟者戒烟率无显著增加(p=0.26)。虽然所有的结果都提示一次或多次的随访建议可以对戒烟产生积极影响，但是从本研究的结果来看，筛查的结果对未来男性吸烟者的戒烟基本无影响。筛查结果可用于教育患者戒烟的一个机会。
（陈欣 审校）
Eur Respir J. 2010 Dec 9. [Epub ahead of print]
The impact of a lung cancer CT screening result on smoking abstinence.
Erasmus MC - University Medical Centre Rotterdam Dr. Molewaterplein 50, 3015 GE Rotterdam The Netherlands.
Abstract
Receiving a lung cancer CT screening result might be a teachable moment for smoking cessation, but it might also unintentionally reassure smokers to continue smoking. The objective was to investigate whether the test result was associated with smoking abstinence in the Dutch-Belgian randomised controlled lung cancer screening trial (NELSON trial). Two random samples of male smokers who had received either only negative test results (n=550) or one or more indeterminate test result (n=440) were sent a questionnaire two years after randomization. Smokers with an indeterminate result reported more quit attempts (p=0.02), but the prolonged abstinence rate in smokers receiving a negative test (8.9%; 46/519) was comparable with the abstinence rate in smokers with one or more indeterminate results (11.5%; 48/419) (p=0.19). A statistically insignificant increase was found after one or >1 indeterminate test results (10.9% and 15.0% respectively) compared with receiving only negative test results (8.9%) (p=0.26). In conclusion, the outcome of the screening test had no impact on future smoking abstinence in male smokers, although all results suggests more favourable implications after one or more follow-up recommendations. Screening test outcomes could be used as a teachable moment for smoking cessation.
Eur Respir J. 2010 Dec 9. [Epub ahead of print]
