戒烟和体重增加对血浆脂联素水平和胰岛素抵抗的早期影响
2011/06/17
摘要
背景：吸烟是动脉粥样硬化和心血管疾病的主要危险因素。研究已经发现，戒烟与体重增加相关，而后者本身也是导致心血管疾病的因素之一。
目的：本试验旨在研究戒烟及其相关体重增加对脂联素水平和胰岛素抵抗的影响。
方法：52名男性习惯性吸烟者采用经皮尼古丁贴剂治疗2个月，对28名成功戒烟的受试者进行分析。受试者根据体重变化分为2个亚组：体重维持组和体重增加组。在研究开始时、贴剂使用结束1周和9周后，检测血清脂联素水平和内环境稳定模型评价比例(HOMA-R)。
结果：对于体重增加者(n=18)，治疗结束后1周，血清脂联素水平呈现增加趋势（平均变化0.4±1.0 µg/mL, p=0.08）。此外，在治疗结束9周后，体重增加者脂联素水平显著下降（治疗后1周和9周间的差异平均为0.8±0.9 µg/mL；p=0.002）。对于体重维持者，在戒烟后脂联素水平轻度增加，变化不显著。在体重增加者，HOMA-R指数显著增加（基线状态和戒烟后9周差异平均为0.4±0.7, p=0.01），而在体重维持者，HOMA-R指数在整个研究过程中无显著变化。
结论：我们的研究结果显示，体重增加的副作用可能会抵消一部分戒烟带来的保护作用。
（陈欣 审校）
Intern Med. 2011;50(7):707-12. Epub 2011 Apr 1.
Early effects of smoking cessation and weight gain on plasma adiponectin levels and insulin resistance.
Inoue K, Takeshima F, Kadota K, Yoda A, Tatsuta Y, Nagaura Y, Yoshioka S, Nakamichi S, Nakao K, Ozono Y.
Department of General Medicine, Nagasaki University School of Medicine, Japan.
Abstract
Background Tobacco smoking is a major risk factor for atherosclerotic and cardiovascular disease. Studies have found evidence that smoking cessation is associated with weight gain, which is itself a leading cause of cardiovascular disease.
Aim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance.
Methods Fifty-two male habitual smokers were treated for 2 months with transdermal nicotine patches, and the 28 subjects who successfully quit smoking were analyzed. Subjects were divided into two sub-groups according to their weight change: weight maintainers and weight gainers. Serum adiponectin levels and the homeostasis model assessment ratio (HOMA-R) were evaluated at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use.
Results In weight gainers (n=18), serum adiponection levels tended to increase at 1 week after the end of treatment (mean difference 0.4±1.0 µg/mL, p=0.08). Moreover, after 9 weeks, adiponectin levels were significantly decreased in weight gainers (mean difference between 1 week and 9 weeks 0.8±0.9 µg/mL, p=0.002). In weight maintainers, adiponectin levels increased slightly after smoking cessation, but changes were not significant. In weight gainers, HOMA-R index was significantly increased (mean difference between baseline and 9 weeks 0.4±0.7, p=0.01), while in weight maintainers, HOMA-R index showed no differences throughout the study.
Conclusion Our findings suggest that the adverse effects of weight gain attenuate some of the beneficial effects of smoking cessation.
Intern Med. 2011;50(7):707-12. Epub 2011 Apr 1.
背景：吸烟是动脉粥样硬化和心血管疾病的主要危险因素。研究已经发现，戒烟与体重增加相关，而后者本身也是导致心血管疾病的因素之一。
目的：本试验旨在研究戒烟及其相关体重增加对脂联素水平和胰岛素抵抗的影响。
方法：52名男性习惯性吸烟者采用经皮尼古丁贴剂治疗2个月，对28名成功戒烟的受试者进行分析。受试者根据体重变化分为2个亚组：体重维持组和体重增加组。在研究开始时、贴剂使用结束1周和9周后，检测血清脂联素水平和内环境稳定模型评价比例(HOMA-R)。
结果：对于体重增加者(n=18)，治疗结束后1周，血清脂联素水平呈现增加趋势（平均变化0.4±1.0 µg/mL, p=0.08）。此外，在治疗结束9周后，体重增加者脂联素水平显著下降（治疗后1周和9周间的差异平均为0.8±0.9 µg/mL；p=0.002）。对于体重维持者，在戒烟后脂联素水平轻度增加，变化不显著。在体重增加者，HOMA-R指数显著增加（基线状态和戒烟后9周差异平均为0.4±0.7, p=0.01），而在体重维持者，HOMA-R指数在整个研究过程中无显著变化。
结论：我们的研究结果显示，体重增加的副作用可能会抵消一部分戒烟带来的保护作用。
（陈欣 审校）
Intern Med. 2011;50(7):707-12. Epub 2011 Apr 1.
Early effects of smoking cessation and weight gain on plasma adiponectin levels and insulin resistance.
Inoue K, Takeshima F, Kadota K, Yoda A, Tatsuta Y, Nagaura Y, Yoshioka S, Nakamichi S, Nakao K, Ozono Y.
Department of General Medicine, Nagasaki University School of Medicine, Japan.
Abstract
Background Tobacco smoking is a major risk factor for atherosclerotic and cardiovascular disease. Studies have found evidence that smoking cessation is associated with weight gain, which is itself a leading cause of cardiovascular disease.
Aim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance.
Methods Fifty-two male habitual smokers were treated for 2 months with transdermal nicotine patches, and the 28 subjects who successfully quit smoking were analyzed. Subjects were divided into two sub-groups according to their weight change: weight maintainers and weight gainers. Serum adiponectin levels and the homeostasis model assessment ratio (HOMA-R) were evaluated at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use.
Results In weight gainers (n=18), serum adiponection levels tended to increase at 1 week after the end of treatment (mean difference 0.4±1.0 µg/mL, p=0.08). Moreover, after 9 weeks, adiponectin levels were significantly decreased in weight gainers (mean difference between 1 week and 9 weeks 0.8±0.9 µg/mL, p=0.002). In weight maintainers, adiponectin levels increased slightly after smoking cessation, but changes were not significant. In weight gainers, HOMA-R index was significantly increased (mean difference between baseline and 9 weeks 0.4±0.7, p=0.01), while in weight maintainers, HOMA-R index showed no differences throughout the study.
Conclusion Our findings suggest that the adverse effects of weight gain attenuate some of the beneficial effects of smoking cessation.
Intern Med. 2011;50(7):707-12. Epub 2011 Apr 1.
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戒烟与心血管专家：加拿大心血管学会建议书
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