男性戒烟与内脏脂肪面积和代谢综合征发病率之间的关系：Hitachi健康研究
2010/12/16
摘要
戒烟后体重增加可能增加患代谢性疾病的风险，包括代谢综合征。随着戒烟时间的延长，该风险是怎样变化的，内脏脂肪面积（VFA）或皮下脂肪面积（SFA）是否与上述风险变化有关，目前尚不清楚。共有5,697名日本男性受试者参与本项研究，这些受试者在健康体检时进行了腹部CT检查。将从不吸烟者设立为参考组，采用logistic回归分析，计算经年龄、饮酒和体力活动校正（模型1）后的各吸烟分类与代谢综合征及其组成部分（采用国家胆固醇教育计划成人治疗小组III标准进行检测）的优势比。其余校正为VFA（模型2）和SFA（模型3）。当前吸烟者具有较低的VFA(120.4 cm2)，既往吸烟者其VFA（124.0-132.0 cm2）高于从不吸烟者（123.1 cm2）。在既往吸烟者中，VFA随着戒烟时间的延长，存在下降趋势。在模型1中，当前吸烟者以及既往吸烟者（已戒烟）患代谢综合征的优势比，在≤4、5～9、10～14和≥15年时分别为1.02、1.33、 1.36、1.40和1.09。既往吸烟者（≤14年）增加的优势比，经VFA（而非SFA校正）校正后，下降35～55.6%。戒烟与代谢性疾病患病风险增加有关，这可能与VFA，而非SFA，相关。
（陈欣 审校）
Obesity (Silver Spring). 2010 Oct 21. [Epub ahead of print]
Associations of Smoking Cessation With Visceral Fat Area and Prevalence of Metabolic Syndrome in Men: The Hitachi Health Study.
Matsushita Y, Nakagawa T, Yamamoto S, Takahashi Y, Noda M, Mizoue T.
Department of Epidemiology and International Health, National Center for Global Health and Medicine, Tokyo, Japan.
Abstract
Weight gain after smoking cessation may deteriorate metabolic risk profiles, including that for metabolic syndrome. How risk profiles change according to the duration of smoking cessation and whether the visceral fat area (VFA) or the subcutaneous fat area (SFA) contributes to these changes remains uncertain. The subjects comprised 5,697 Japanese men who underwent an abdominal computed-tomography examination during a health check-up. Using never smokers as a reference group, the odds ratios of having metabolic syndrome and its components, defined using the National Cholesterol Education Program Adult Treatment Panel III criteria, were calculated for each smoking category with adjustments for age, alcohol drinking, and physical activity (model 1) using a logistic regression analysis. Additional adjustments were also made for either VFA (model 2) or SFA (model 3). Current smokers had the lowest VFA (120.4 cm2) whereas ex-smokers (124.0-132.0 cm(2)) had a higher VFA than nonsmokers (123.1 cm(2)). Among the ex-smokers, VFA tended to decrease with increasing years of smoking cessation. In model 1, the odds ratios of having metabolic syndrome for current smokers and ex-smokers with smoking cessation for ≤4, 5-9, 10-14, and ≥15 years were 1.02, 1.33, 1.36, 1.40, and 1.09, respectively. The elevated odds ratios among ex-smokers (≤14 years) were reduced by 35-55.6% after further adjustment for VFA but not for SFA. Smoking cessation is associated with a deterioration of the metabolic risk profile, which can be ascribed, at least in part, to an increase in VFA not SFA.
Obesity (Silver Spring). 2010 Oct 21. [Epub ahead of print]
戒烟后体重增加可能增加患代谢性疾病的风险，包括代谢综合征。随着戒烟时间的延长，该风险是怎样变化的，内脏脂肪面积（VFA）或皮下脂肪面积（SFA）是否与上述风险变化有关，目前尚不清楚。共有5,697名日本男性受试者参与本项研究，这些受试者在健康体检时进行了腹部CT检查。将从不吸烟者设立为参考组，采用logistic回归分析，计算经年龄、饮酒和体力活动校正（模型1）后的各吸烟分类与代谢综合征及其组成部分（采用国家胆固醇教育计划成人治疗小组III标准进行检测）的优势比。其余校正为VFA（模型2）和SFA（模型3）。当前吸烟者具有较低的VFA(120.4 cm2)，既往吸烟者其VFA（124.0-132.0 cm2）高于从不吸烟者（123.1 cm2）。在既往吸烟者中，VFA随着戒烟时间的延长，存在下降趋势。在模型1中，当前吸烟者以及既往吸烟者（已戒烟）患代谢综合征的优势比，在≤4、5～9、10～14和≥15年时分别为1.02、1.33、 1.36、1.40和1.09。既往吸烟者（≤14年）增加的优势比，经VFA（而非SFA校正）校正后，下降35～55.6%。戒烟与代谢性疾病患病风险增加有关，这可能与VFA，而非SFA，相关。
（陈欣 审校）
Obesity (Silver Spring). 2010 Oct 21. [Epub ahead of print]
Associations of Smoking Cessation With Visceral Fat Area and Prevalence of Metabolic Syndrome in Men: The Hitachi Health Study.
Matsushita Y, Nakagawa T, Yamamoto S, Takahashi Y, Noda M, Mizoue T.
Department of Epidemiology and International Health, National Center for Global Health and Medicine, Tokyo, Japan.
Abstract
Weight gain after smoking cessation may deteriorate metabolic risk profiles, including that for metabolic syndrome. How risk profiles change according to the duration of smoking cessation and whether the visceral fat area (VFA) or the subcutaneous fat area (SFA) contributes to these changes remains uncertain. The subjects comprised 5,697 Japanese men who underwent an abdominal computed-tomography examination during a health check-up. Using never smokers as a reference group, the odds ratios of having metabolic syndrome and its components, defined using the National Cholesterol Education Program Adult Treatment Panel III criteria, were calculated for each smoking category with adjustments for age, alcohol drinking, and physical activity (model 1) using a logistic regression analysis. Additional adjustments were also made for either VFA (model 2) or SFA (model 3). Current smokers had the lowest VFA (120.4 cm2) whereas ex-smokers (124.0-132.0 cm(2)) had a higher VFA than nonsmokers (123.1 cm(2)). Among the ex-smokers, VFA tended to decrease with increasing years of smoking cessation. In model 1, the odds ratios of having metabolic syndrome for current smokers and ex-smokers with smoking cessation for ≤4, 5-9, 10-14, and ≥15 years were 1.02, 1.33, 1.36, 1.40, and 1.09, respectively. The elevated odds ratios among ex-smokers (≤14 years) were reduced by 35-55.6% after further adjustment for VFA but not for SFA. Smoking cessation is associated with a deterioration of the metabolic risk profile, which can be ascribed, at least in part, to an increase in VFA not SFA.
Obesity (Silver Spring). 2010 Oct 21. [Epub ahead of print]
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