亚洲人群中戒烟与肺癌风险：来自新加坡华人健康研究的发现
2010/11/03
摘要
背景：戒烟是减少烟草危害的重要措施，特别是能预防肺癌的发生。然而，有关戒烟对亚洲人群肺癌风险的影响的前瞻性数据十分有限。
方法：对年龄为45～74岁的男性和女性华人进行一项基于人群的队列研究，参与者来自于新加坡华人健康研究。在参与者入选本研究（1993～1998年）时收集有关吸烟、生活方式、饮食习惯的信息，于1999～2004年再次随访时对吸烟状态进行评价（平均间隔5.8年）。参与者随访至2007年12月31日，肺癌患者通过人群注册表进行确认。
结果：在45900名参与者中，463名出现肺癌。与当前吸烟者相比，基线状态评估后即戒烟的参与者，其肺癌的患病风险下降28%（校正后风险比HR：0.72; 95% CI：0.53-0.98）。首次访谈前就已经戒烟、且一直维持戒烟状态的既往吸烟者，该风险降低到一半以下（HR 0.42; 95% CI: 0.32-0.56）。
结论：亚洲人群肺癌发生率随着戒烟而明显下降，而且该现象在戒烟后几年内仍能观察到。
（林江涛 审校）
Br J Cancer. 2010 Sep 14. [Epub ahead of print]
Smoking cessation and lung cancer risk in an Asian population: Findings from the Singapore Chinese Health Study.
Wong KY, Seow A, Koh WP, Shankar A, Lee HP, Yu MC.
Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore.
Abstract
Background: Smoking cessation is an important strategy for reducing the harmful effects of tobacco, particularly in the prevention of lung cancer; however, prospective data on the impact of smoking cessation on lung cancer risk in Asian populations are limited.
Methods:We studied a population-based cohort of Chinese men and women aged 45-74 years - participants of the Singapore Chinese Health Study. Information on smoking, lifestyle and dietary habits was collected at the time of recruitment in 1993-1998; and smoking status was assessed again at a second interview in 1999-2004 (mean interval 5.8 years). Participants were followed up to 31 December 2007, and incident cases of lung cancer were ascertained by linkage with population-wide registries.
Results:Among 45 900 participants, there were 463 incident cases of lung cancer. Relative to current smokers, those who quit smoking subsequent to baseline assessment had a 28% decrease in the risk of lung cancer (adjusted hazard ratio (HR) 0.72; 95% CI (95% confidence interval): 0.53-0.98). The risk was less than half in ex-smokers who had quit before the first interview and maintained their status (HR 0.42; 95% CI: 0.32-0.56).
Conclusions:Reduction in lung cancer incidence with smoking cessation in Asian populations is substantial and can be observed within a few years after quitting。
Br J Cancer. 2010 Sep 14. [Epub ahead of print]
背景：戒烟是减少烟草危害的重要措施，特别是能预防肺癌的发生。然而，有关戒烟对亚洲人群肺癌风险的影响的前瞻性数据十分有限。
方法：对年龄为45～74岁的男性和女性华人进行一项基于人群的队列研究，参与者来自于新加坡华人健康研究。在参与者入选本研究（1993～1998年）时收集有关吸烟、生活方式、饮食习惯的信息，于1999～2004年再次随访时对吸烟状态进行评价（平均间隔5.8年）。参与者随访至2007年12月31日，肺癌患者通过人群注册表进行确认。
结果：在45900名参与者中，463名出现肺癌。与当前吸烟者相比，基线状态评估后即戒烟的参与者，其肺癌的患病风险下降28%（校正后风险比HR：0.72; 95% CI：0.53-0.98）。首次访谈前就已经戒烟、且一直维持戒烟状态的既往吸烟者，该风险降低到一半以下（HR 0.42; 95% CI: 0.32-0.56）。
结论：亚洲人群肺癌发生率随着戒烟而明显下降，而且该现象在戒烟后几年内仍能观察到。
（林江涛 审校）
Br J Cancer. 2010 Sep 14. [Epub ahead of print]
Smoking cessation and lung cancer risk in an Asian population: Findings from the Singapore Chinese Health Study.
Wong KY, Seow A, Koh WP, Shankar A, Lee HP, Yu MC.
Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore.
Abstract
Background: Smoking cessation is an important strategy for reducing the harmful effects of tobacco, particularly in the prevention of lung cancer; however, prospective data on the impact of smoking cessation on lung cancer risk in Asian populations are limited.
Methods:We studied a population-based cohort of Chinese men and women aged 45-74 years - participants of the Singapore Chinese Health Study. Information on smoking, lifestyle and dietary habits was collected at the time of recruitment in 1993-1998; and smoking status was assessed again at a second interview in 1999-2004 (mean interval 5.8 years). Participants were followed up to 31 December 2007, and incident cases of lung cancer were ascertained by linkage with population-wide registries.
Results:Among 45 900 participants, there were 463 incident cases of lung cancer. Relative to current smokers, those who quit smoking subsequent to baseline assessment had a 28% decrease in the risk of lung cancer (adjusted hazard ratio (HR) 0.72; 95% CI (95% confidence interval): 0.53-0.98). The risk was less than half in ex-smokers who had quit before the first interview and maintained their status (HR 0.42; 95% CI: 0.32-0.56).
Conclusions:Reduction in lung cancer incidence with smoking cessation in Asian populations is substantial and can be observed within a few years after quitting。
Br J Cancer. 2010 Sep 14. [Epub ahead of print]
上一篇：
GSTP1多态性和烟草烟雾暴露在儿童急性哮喘中的作用
下一篇：
吸烟者出现急性咳嗽的初始治疗是否应包括抗生素治疗？——一项13个欧洲国家的观察研究
