戒烟过程中心-踝血管指数的变化
2010/07/07
目的：研究吸烟和戒烟对心-踝血管指数（CAVI）的影响。
方法：82名吸烟者（77名男性，平均64+/-10岁）和20名非吸烟者（18名男性，61+/-7岁）入选本研究。CAVI每3个月检测1次，CAVI严重程度分为4个水平。CAVI水平下降、无变化及增加，分别标记为改善、无变化和恶化。吸烟状态分为完全成功戒断、部分成功戒断（吸烟数量减少）、无戒断（吸烟数量不变）。
结果：与非吸烟者相比，吸烟者戒断前具有较高的CAVI（P<0.05）。戒断后，CAVI明显改善（成功戒断者：从9.4降至8.6，n=22，P<0.01），而且戒断前与非吸烟者的差异，在戒断后消失（非吸烟者n=20, CAVI=8.8）。在戒烟失败（n=35）、部分成功戒断（n=25）和成功戒断（n=22）吸烟者中，严重程度得到改善的患者分别占17%、24%和68%吸烟者。此外，成功戒烟组，严重程度得到改善的吸烟者比率显著高于其他两组。
结论：本项研究显示，吸烟者CAVI显著增加，完全戒断能有效改善CAVI。
（陈欣 审校）
Noike H, et al. J Atheroscler Thromb. 2010 Mar 9. [Epub ahead of print]
Noike H, et al. J Atheroscler Thromb. 2010 Mar 9. [Epub ahead of print]
Changes in Cardio-Ankle Vascular Index in Smoking Cessation.
Noike H, Nakamura K, Sugiyama Y, Iizuka T, Shimizu K, Takahashi M, Hirano K, Suzuki M, Mikamo H, Nakagami T, Shirai K.
Department of Cardiovascular Center, Sakura Medical Center, School of Medicine, Toho University.
Aim: To investigate the effect of smoking and smoking cessation on cardio-ankle vascular index (CAVI).
Methods: The subjects were 82 smokers (77 men, 64+/-10 years) and 20 non-smokers (18 men, 61+/-7 years). CAVI was measured every 3 months and CAVI severity was classified into 4 levels. Decreased, unchanged, and increased CAVI severity levels were coded as "improvement," "no change," and "exacerbation," respectively. Smoking status was coded as "success" for complete abstinence, "partial success" for a reduced number of cigarettes, and "failure" for an unchanging number of cigarettes.
Results: Compared with non-smokers, smokers showed a higher CAVI (p<0.05) prior to smoking cessation. Post-cessation, CAVI improved from 9.4 to 8.6 (p<0.01) in "success" cases (n=22), and the significant pre-cessation difference from non-smokers (n=20, CAVI=8.8) disappeared. With regard to the change in CAVI severity of each smoking status, "improvement" occurred in 17%, 24%, and 68% of "failure" (n=35), "partial success" (n=25), and "success" (n=22) groups, respectively, and the "success" group was significantly higher than the other two groups.
Conclusion: The study showed that CAVI was increased by smoking, and complete smoking cessation improved CAVI.
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