脑源性神经营养因子水平与哮喘患者的抑郁症状相关
2025/11/28
摘要
背景：重度抑郁症患者的中枢及循环系统中的脑源性神经营养因子（BDNF）水平降低，血清BDNF被提出可作为重度抑郁症的潜在生物标志物。相反，动物研究表明，BDNF水平的升高可能与哮喘的气道病理有关。本研究旨在探讨哮喘患者中与血清BDNF水平和抑郁症状相关的因素。
方法：我们纳入了140名哮喘患者。采用酶联免疫吸附法测定血清BDNF水平。使用医院焦虑抑郁量表（HADS）评估抑郁和焦虑症状。通过三轴加速度计评估日常身体活动量。首先，我们调查了与哮喘患者血清BDNF水平相关的因素；其次，我们检查了与HADS抑郁评分相关的临床变量。
结果：哮喘患者的血清BDNF水平与其抑郁症状的严重程度呈正相关。多变量线性回归分析显示，BDNF水平升高与HADS抑郁评分升高以及哮喘严重程度增加相关。此外，高HADS抑郁评分还与较低的身体活动水平和较差的哮喘控制相关。
结论：哮喘患者的血清BDNF水平与其抑郁症状和哮喘严重程度均呈正相关。这些研究结果表明，哮喘患者抑郁症状的发生机制可能与重度抑郁症不同，尤其是在BDNF所起的作用方面。
背景：重度抑郁症患者的中枢及循环系统中的脑源性神经营养因子（BDNF）水平降低，血清BDNF被提出可作为重度抑郁症的潜在生物标志物。相反，动物研究表明，BDNF水平的升高可能与哮喘的气道病理有关。本研究旨在探讨哮喘患者中与血清BDNF水平和抑郁症状相关的因素。
方法：我们纳入了140名哮喘患者。采用酶联免疫吸附法测定血清BDNF水平。使用医院焦虑抑郁量表（HADS）评估抑郁和焦虑症状。通过三轴加速度计评估日常身体活动量。首先，我们调查了与哮喘患者血清BDNF水平相关的因素；其次，我们检查了与HADS抑郁评分相关的临床变量。
结果：哮喘患者的血清BDNF水平与其抑郁症状的严重程度呈正相关。多变量线性回归分析显示，BDNF水平升高与HADS抑郁评分升高以及哮喘严重程度增加相关。此外，高HADS抑郁评分还与较低的身体活动水平和较差的哮喘控制相关。
结论：哮喘患者的血清BDNF水平与其抑郁症状和哮喘严重程度均呈正相关。这些研究结果表明，哮喘患者抑郁症状的发生机制可能与重度抑郁症不同，尤其是在BDNF所起的作用方面。
（中日友好医院呼吸与危重症医学科 沈焜路 摘译 林江涛 审校）
（J Allergy Clin Immunol Pract. 2025 Nov 11; DOI: 10.1016/j.jaip.2025.11.001 ）
Brain-Derived Neurotrophic Factor Levels Are Associated with Depressive Symptoms in Patients with Asthma
Kawamoto, K., Iwamoto, H., Hirano, T., Amano, Y., Fukatsu-Chikumoto, A., Yamane, M., Otani, T., Higaki, N., Isobe, T., Yokoyama, A., Matsunaga, K., & Hattori, N
Abstract
BACKGROUND:Patients with major depressive disorder exhibit reduced central and circulatory levels of brain-derived neurotrophic factor (BDNF), with serum BDNF being proposed as a potential biomarker for major depression. Contrastingly, animal studies have suggested that elevated BDNF levels may be associated with airway pathology in asthma. This study aimed to identify factors associated with serum BDNF levels and depressive symptoms in patients with asthma.
METHODS:We included 140 patients with asthma. Serum BDNF levels were measured using enzyme-linked immunosorbent assay. Depressive and anxiety symptoms were evaluated using the Hospital Anxiety and Depression Scale (HADS). Daily physical activity was assessed using a triaxial accelerometer. First, we investigated factors associated with serum BDNF levels in patients with asthma. Second, we examined clinical variables related to HADS depression scores.
RESULTS:Serum BDNF levels were positively associated with the severity of depressive symptoms in patients with asthma. Multivariable linear regression analysis demonstrated that elevated BDNF levels were associated with increased HADS depression scores and greater asthma severity. Additionally, high HADS depression scores were also associated with lower physical activity levels and poor asthma control.
CONCLUSION:Serum BDNF levels are positively associated with both depressive symptoms and asthma severity in patients with asthma. These findings suggest that the mechanisms underlying depressive symptoms in patients with asthma may differ from those in major depression, particularly with respect to the role of BDNF.
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