摘要
背景及目的：本文旨在探讨25-羟基维生素D[25-(OH)-D]、白细胞介素-4（IL-4）和干扰素-γ（IFN-γ）与肺炎支原体（MP）感染相关儿童支气管哮喘的相关性。
方法：本研究通过逻辑分析，比较MP哮喘组和MP非哮喘组的一般数据，并检测25-(OH)-D、IL-4和IFN-γ的水平，进行组间比较。另外，本研究采用受试者工作特征曲线（ROC）以检验各变量的预测值。
结果：逻辑回归分析结果表明，无论是否罹患哮喘，复发性上呼吸道感染和集体生活都与MP感染的发生率有关。MP哮喘组受试者的IL-4和IFN-γ水平显著高于MP非哮喘组和对照组（p<0.01）。而MP哮喘组受试者的25-(OH)-D和IFN-γ/IL-4明显低于MP非哮喘组和对照组（p<0.05）。ROC曲线显示，25-(OH)-D、IL-4、IFN-γ、IFN-γ/IL-4和联合检测用于诊断MP感染相关哮喘的曲线下面积（AUC）分别为0.765、0.780、0.853、0.638和0.912，联合检测的敏感性和特异性均大于95%。
结论：对于罹患MP感染相关哮喘的儿童，IL-4和IFN-γ表达水平上调，25-(OH)-D表达水平下调。联合检测25-(OH)-D、IL-4、IFN-γ和IFN-γ/IL-4可提高MP感染相关哮喘的诊断能力。
Association between 25-hydroxy vitamin D, interleukin-4, and interferon-γ levels and asthma in children with Mycoplasma pneumonia infection.
Shen T, Liu T, Kong L, Li Y.
Abstract
BACKGROUND & OBJECTIVE:To explore the association between 25-hydroxy vitamin D [25-(OH)-D], interleukin-4 (IL-4), and interferon-γ (IFN-γ) in children with Mycoplasma pneumoniae (MP) infection-related asthma.
METHODS:Logistic analysis was conducted to compare general data in MP asthma and MP non-asthma groups. The level of 25-(OH)-D, IL-4, and IFN-γ were detected and compared between groups. Moreover, the receiver operating characteristic curve (ROC) was applied to test the predictive value of each variable.
RESULTS:The results of logistic regression analysis demonstrated that recurrent upper respiratory tract infections and collective living are related to the incidence of MP infection whether with asthma or without asthma. IL-4 and IFN-γ in MP asthma group were significantly higher than those in MP non-asthma group and control group (p < 0. 05), whilst 25-(OH)-D and IFN-γ/IL-4 in MP asthma group were significantly lower than those in MP non-asthma group and control group (p < 0. 05). ROC curves indicated that the area under the curve (AUC) of 25-(OH)-D, IL-4, IFN-γ, IFN-γ/IL-4, and joint detection are 0.765, 0.780, 0.853, 0.638, and 0.912 in diagnosis of MP infection-related asthma, and sensitivity and specificity of joint detection are both greater than 95%. For children with MP infection-related asthma, the level of IL-4 and IFN-γ is upregulated, while 25-(OH)-D is downregulated.
CONCLUSION:The joint detection of 25-(OH)-D, IL-4, IFN-γ, and IFN-γ/IL-4 may improve diagnostic capabilities of MP infection-related asthma.
背景及目的：本文旨在探讨25-羟基维生素D[25-(OH)-D]、白细胞介素-4（IL-4）和干扰素-γ（IFN-γ）与肺炎支原体（MP）感染相关儿童支气管哮喘的相关性。
方法：本研究通过逻辑分析，比较MP哮喘组和MP非哮喘组的一般数据，并检测25-(OH)-D、IL-4和IFN-γ的水平，进行组间比较。另外，本研究采用受试者工作特征曲线（ROC）以检验各变量的预测值。
结果：逻辑回归分析结果表明，无论是否罹患哮喘，复发性上呼吸道感染和集体生活都与MP感染的发生率有关。MP哮喘组受试者的IL-4和IFN-γ水平显著高于MP非哮喘组和对照组（p<0.01）。而MP哮喘组受试者的25-(OH)-D和IFN-γ/IL-4明显低于MP非哮喘组和对照组（p<0.05）。ROC曲线显示，25-(OH)-D、IL-4、IFN-γ、IFN-γ/IL-4和联合检测用于诊断MP感染相关哮喘的曲线下面积（AUC）分别为0.765、0.780、0.853、0.638和0.912，联合检测的敏感性和特异性均大于95%。
结论：对于罹患MP感染相关哮喘的儿童，IL-4和IFN-γ表达水平上调，25-(OH)-D表达水平下调。联合检测25-(OH)-D、IL-4、IFN-γ和IFN-γ/IL-4可提高MP感染相关哮喘的诊断能力。
(中日友好医院呼吸与危重症医学科 张婧媛 摘译 林江涛 审校)
(Sci Rep. 2024 Nov 21;14(1):28854. doi: 10.1038/s41598-024-80322-4.)
(Sci Rep. 2024 Nov 21;14(1):28854. doi: 10.1038/s41598-024-80322-4.)
Association between 25-hydroxy vitamin D, interleukin-4, and interferon-γ levels and asthma in children with Mycoplasma pneumonia infection.
Shen T, Liu T, Kong L, Li Y.
Abstract
BACKGROUND & OBJECTIVE:To explore the association between 25-hydroxy vitamin D [25-(OH)-D], interleukin-4 (IL-4), and interferon-γ (IFN-γ) in children with Mycoplasma pneumoniae (MP) infection-related asthma.
METHODS:Logistic analysis was conducted to compare general data in MP asthma and MP non-asthma groups. The level of 25-(OH)-D, IL-4, and IFN-γ were detected and compared between groups. Moreover, the receiver operating characteristic curve (ROC) was applied to test the predictive value of each variable.
RESULTS:The results of logistic regression analysis demonstrated that recurrent upper respiratory tract infections and collective living are related to the incidence of MP infection whether with asthma or without asthma. IL-4 and IFN-γ in MP asthma group were significantly higher than those in MP non-asthma group and control group (p < 0. 05), whilst 25-(OH)-D and IFN-γ/IL-4 in MP asthma group were significantly lower than those in MP non-asthma group and control group (p < 0. 05). ROC curves indicated that the area under the curve (AUC) of 25-(OH)-D, IL-4, IFN-γ, IFN-γ/IL-4, and joint detection are 0.765, 0.780, 0.853, 0.638, and 0.912 in diagnosis of MP infection-related asthma, and sensitivity and specificity of joint detection are both greater than 95%. For children with MP infection-related asthma, the level of IL-4 and IFN-γ is upregulated, while 25-(OH)-D is downregulated.
CONCLUSION:The joint detection of 25-(OH)-D, IL-4, IFN-γ, and IFN-γ/IL-4 may improve diagnostic capabilities of MP infection-related asthma.
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