抗体介导的免疫反应对慢性阻塞性肺病、哮喘和肺功能的影响： 孟德尔随机化研究
2024/11/29
摘要
背景：抗体介导的免疫反应对慢性阻塞性肺疾病（COPD）、哮喘和肺功能的确切影响尚不清楚。我们研究了抗体介导的免疫反应与慢性阻塞性肺疾病、哮喘和肺功能之间的关系，最终达到预防或治疗的目的。
方法：我们从已发表的全基因组关联研究中获取了汇总数据，包括抗体介导的免疫反应、慢性阻塞性肺病、哮喘、第一秒用力呼气容积（FEV1）、用力呼气容积（FVC）和 FEV1/FVC。双向两样本孟德尔随机化（MR）分析用于评估抗体介导的免疫反应、慢性阻塞性肺病、哮喘、FEV1、FVC 和 FEV1/FVC 的因果关系。
结果：共发现 20 种抗体介导的免疫反应对慢性阻塞性肺病、哮喘、FEV1 和 FVC 有显著的因果关系，其中 6 种表现出反向因果关系。重要的是，在抗多瘤病毒 2 IgG 血清阳性和水痘带状疱疹病毒糖蛋白 E 和 I 抗体水平对慢性阻塞性肺病、哮喘、FEV1 和 FVC 风险的因果效应方面，五项 MR 分析的结果几乎相同。
结论：本研究采用双样本 MR 设计，调查了抗体介导的免疫反应与慢性阻塞性肺病、哮喘和肺功能等呼吸系统疾病之间的因果关系，为现有知识做出了贡献。主要发现有助于识别这些疾病的高危人群，促进早期预防和诊断。
Effect of the Antibody-mediated Immune Responses on COPD, Asthma, and Lung Function: A Mendelian Randomization Study
Guixing X, Yilin L, Huaying F, Fanrong L, Dehua L.
Abstract
Background:The precise cause of antibody-mediated immune responses on chronic obstructive pulmonary disease (COPD), asthma, and lung function remains unclear. We characterized the relationship between antibody-mediated immune responses to COPD, asthma, and lung function, ultimately achieve the prevention or treatment.
Methods:We obtained summary data from published genome-wide association studies, including antibody-mediated immune responses, COPD, asthma, forced expiratory volume in the first second (FEV1), forced expiratory volume (FVC), and FEV1/FVC. Bidirectional two-sample mendelian randomization (MR) analysis was used to assess causal relationships of antibody-mediated immune responses, COPD, asthma, FEV1, FVC, and FEV1/FVC.
Results:A total of 20 antibody-mediated immune responses were identified have a significant causal effect on COPD, asthma, FEV1, and FVC, with six exhibiting reverse causality. Importantly, the results of the five MR analyses were almost identical with respect to the causal effect of anti-polyomavirus 2 IgG seropositivity and varicella zoster virus glycoprotein E and I antibody levels on the risk of COPD, asthma, FEV1, and FVC.
Conclusion:This study contributes to existing knowledge by investigating the causal relationship between antibody-mediated immune responses and respiratory conditions, including COPD, asthma, and lung function, using a two-sample MR design. The key findings can aid in identifying individuals at risk of these conditions and facilitate early prevention and diagnosis.
背景：抗体介导的免疫反应对慢性阻塞性肺疾病（COPD）、哮喘和肺功能的确切影响尚不清楚。我们研究了抗体介导的免疫反应与慢性阻塞性肺疾病、哮喘和肺功能之间的关系，最终达到预防或治疗的目的。
方法：我们从已发表的全基因组关联研究中获取了汇总数据，包括抗体介导的免疫反应、慢性阻塞性肺病、哮喘、第一秒用力呼气容积（FEV1）、用力呼气容积（FVC）和 FEV1/FVC。双向两样本孟德尔随机化（MR）分析用于评估抗体介导的免疫反应、慢性阻塞性肺病、哮喘、FEV1、FVC 和 FEV1/FVC 的因果关系。
结果：共发现 20 种抗体介导的免疫反应对慢性阻塞性肺病、哮喘、FEV1 和 FVC 有显著的因果关系，其中 6 种表现出反向因果关系。重要的是，在抗多瘤病毒 2 IgG 血清阳性和水痘带状疱疹病毒糖蛋白 E 和 I 抗体水平对慢性阻塞性肺病、哮喘、FEV1 和 FVC 风险的因果效应方面，五项 MR 分析的结果几乎相同。
结论：本研究采用双样本 MR 设计，调查了抗体介导的免疫反应与慢性阻塞性肺病、哮喘和肺功能等呼吸系统疾病之间的因果关系，为现有知识做出了贡献。主要发现有助于识别这些疾病的高危人群，促进早期预防和诊断。
(中日友好医院呼吸与危重症医学科 沈焜路 摘译 林江涛 审校)
(Arch Bronconeumol. 2024 Oct 22; DOI: 10.1016/j.arbres.2024.10.003)
(Arch Bronconeumol. 2024 Oct 22; DOI: 10.1016/j.arbres.2024.10.003)
Effect of the Antibody-mediated Immune Responses on COPD, Asthma, and Lung Function: A Mendelian Randomization Study
Guixing X, Yilin L, Huaying F, Fanrong L, Dehua L.
Abstract
Background:The precise cause of antibody-mediated immune responses on chronic obstructive pulmonary disease (COPD), asthma, and lung function remains unclear. We characterized the relationship between antibody-mediated immune responses to COPD, asthma, and lung function, ultimately achieve the prevention or treatment.
Methods:We obtained summary data from published genome-wide association studies, including antibody-mediated immune responses, COPD, asthma, forced expiratory volume in the first second (FEV1), forced expiratory volume (FVC), and FEV1/FVC. Bidirectional two-sample mendelian randomization (MR) analysis was used to assess causal relationships of antibody-mediated immune responses, COPD, asthma, FEV1, FVC, and FEV1/FVC.
Results:A total of 20 antibody-mediated immune responses were identified have a significant causal effect on COPD, asthma, FEV1, and FVC, with six exhibiting reverse causality. Importantly, the results of the five MR analyses were almost identical with respect to the causal effect of anti-polyomavirus 2 IgG seropositivity and varicella zoster virus glycoprotein E and I antibody levels on the risk of COPD, asthma, FEV1, and FVC.
Conclusion:This study contributes to existing knowledge by investigating the causal relationship between antibody-mediated immune responses and respiratory conditions, including COPD, asthma, and lung function, using a two-sample MR design. The key findings can aid in identifying individuals at risk of these conditions and facilitate early prevention and diagnosis.
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