中度与剧烈运动训练对成人哮喘预后的影响
2024/07/30
摘要
背景：运动的治疗效果促使人们呼吁将其纳入标准的哮喘护理，但缺乏提供最佳运动强度的证据。
目的：本研究旨在比较中等强度和高强度有氧运动训练对哮喘结局和炎症的影响。
方法：这是一项为期12周的随机对照试验，46名哮喘成人随机分为1）每周三次45min中等强度运动训练，2）每周三次30min高强度运动训练，或3）对照组。干预前后评估哮喘相关生活质量（AQLQ），哮喘控制（ACQ），心肺功能，身体成分，气道和全身炎症。
结果：41名参与者完成了该研究（保留率为89%）。与对照组相比，中等强度组的AQLQ（0.63 [0.33-0.93]，P < .001）和ACQ（-0.51 [-0.83至-0.19]，P = .003）有统计学和临床意义的改善。与对照组相比，剧烈强度组的AQLQ（0.46 [0.14-0.80]，P = .007）和ACQ（-0.36 [-0.69至-0.02]，P = .040）有统计学上的改善，但无临床上显着改善。中等强度训练后，痰巨噬细胞（-1341 [-2491至-191] × 104/mL，P = .024）和淋巴细胞（-114 [-220 至 -8] × 104/mL，P = .036）计数相对于对照组减少。不影响健康的脂肪量的减少，与 AQLQ （rs = -0.341， P = .030） 和痰液 IL-6 减少（rs = 0.422， P = .013）有关。
结论：我们的研究结果表明，中等强度和高强度有氧运动训练与临床哮喘结局的改善有关，因此两种强度均可推荐作为辅助哮喘治疗。
Effects of Moderate-Versus Vigorous-Intensity Exercise Training on Asthma Outcomes in Adults.
Sarah R, Valkenborghs; Lisa G, Wood;
Abstrast
Background: The therapeutic effects of exercise have prompted calls for it to be embedded into standard asthma care, but evidence informing the optimal exercise intensity is lacking.
Objective：This study aimed to compare the effects of moderate- and vigorous-intensity aerobic exercise training on asthma outcomes and inflammation.
Methods: This was a 12-week randomized controlled trial in 46 adults with asthma randomized to either (1) 45-minute moderate-intensity exercise training 3 times/wk, (2) 30-minute vigorous-intensity exercise training 3 times/wk, or (3) the control group. Asthma-related quality of life (AQLQ), asthma control (ACQ), cardiorespiratory fitness, body composition, and airway and systemic inflammation were assessed before and after the intervention.
Results: Forty-one participants completed the study (89% retention). The moderate-intensity group had a statistically and clinically significant improvement in AQLQ (0.63 [0.33-0.93], P < .001) and ACQ (-0.51 [-0.83 to -0.19], P = .003) relative to control. The vigorous-intensity group had a statistically, but not clinically, significant improvement in AQLQ (0.46 [0.14-0.80], P = .007) and ACQ (-0.36 [-0.69 to -0.02], P = .040) relative to control. After moderate-intensity training, there was a reduction in sputum macrophage (-1341 [-2491 to -191] × 104/mL, P = .024) and lymphocyte (-114 [-220 to -8] × 104/mL, P = .036) counts relative to control. A reduction in android fat mass, but not a change in fitness, was associated with improved AQLQ (rs = -0.341, P = .030) and reduced sputum IL-6 (rs = 0.422, P = .013).
Conclusions：Our findings suggest that both moderate-intensity and vigorous-intensity aerobic exercise training are associated with improvements in clinical asthma outcomes and, therefore, both intensities could be recommended as an adjuvant asthma therapy.
背景：运动的治疗效果促使人们呼吁将其纳入标准的哮喘护理，但缺乏提供最佳运动强度的证据。
目的：本研究旨在比较中等强度和高强度有氧运动训练对哮喘结局和炎症的影响。
方法：这是一项为期12周的随机对照试验，46名哮喘成人随机分为1）每周三次45min中等强度运动训练，2）每周三次30min高强度运动训练，或3）对照组。干预前后评估哮喘相关生活质量（AQLQ），哮喘控制（ACQ），心肺功能，身体成分，气道和全身炎症。
结果：41名参与者完成了该研究（保留率为89%）。与对照组相比，中等强度组的AQLQ（0.63 [0.33-0.93]，P < .001）和ACQ（-0.51 [-0.83至-0.19]，P = .003）有统计学和临床意义的改善。与对照组相比，剧烈强度组的AQLQ（0.46 [0.14-0.80]，P = .007）和ACQ（-0.36 [-0.69至-0.02]，P = .040）有统计学上的改善，但无临床上显着改善。中等强度训练后，痰巨噬细胞（-1341 [-2491至-191] × 104/mL，P = .024）和淋巴细胞（-114 [-220 至 -8] × 104/mL，P = .036）计数相对于对照组减少。不影响健康的脂肪量的减少，与 AQLQ （rs = -0.341， P = .030） 和痰液 IL-6 减少（rs = 0.422， P = .013）有关。
结论：我们的研究结果表明，中等强度和高强度有氧运动训练与临床哮喘结局的改善有关，因此两种强度均可推荐作为辅助哮喘治疗。
(中日友好医院呼吸与危重症医学科 万静萱 摘译 林江涛 审校)
(J Allergy Clin Immunol Pract 2024 Jun 18;0(0)；doi: 10.1016/j.jaip.2024.06.015.)
(J Allergy Clin Immunol Pract 2024 Jun 18;0(0)；doi: 10.1016/j.jaip.2024.06.015.)
Effects of Moderate-Versus Vigorous-Intensity Exercise Training on Asthma Outcomes in Adults.
Sarah R, Valkenborghs; Lisa G, Wood;
Abstrast
Background: The therapeutic effects of exercise have prompted calls for it to be embedded into standard asthma care, but evidence informing the optimal exercise intensity is lacking.
Objective：This study aimed to compare the effects of moderate- and vigorous-intensity aerobic exercise training on asthma outcomes and inflammation.
Methods: This was a 12-week randomized controlled trial in 46 adults with asthma randomized to either (1) 45-minute moderate-intensity exercise training 3 times/wk, (2) 30-minute vigorous-intensity exercise training 3 times/wk, or (3) the control group. Asthma-related quality of life (AQLQ), asthma control (ACQ), cardiorespiratory fitness, body composition, and airway and systemic inflammation were assessed before and after the intervention.
Results: Forty-one participants completed the study (89% retention). The moderate-intensity group had a statistically and clinically significant improvement in AQLQ (0.63 [0.33-0.93], P < .001) and ACQ (-0.51 [-0.83 to -0.19], P = .003) relative to control. The vigorous-intensity group had a statistically, but not clinically, significant improvement in AQLQ (0.46 [0.14-0.80], P = .007) and ACQ (-0.36 [-0.69 to -0.02], P = .040) relative to control. After moderate-intensity training, there was a reduction in sputum macrophage (-1341 [-2491 to -191] × 104/mL, P = .024) and lymphocyte (-114 [-220 to -8] × 104/mL, P = .036) counts relative to control. A reduction in android fat mass, but not a change in fitness, was associated with improved AQLQ (rs = -0.341, P = .030) and reduced sputum IL-6 (rs = 0.422, P = .013).
Conclusions：Our findings suggest that both moderate-intensity and vigorous-intensity aerobic exercise training are associated with improvements in clinical asthma outcomes and, therefore, both intensities could be recommended as an adjuvant asthma therapy.
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