孕期母亲焦虑与学龄前儿童哮喘的关系：马鞍山出生队列研究
2023/10/25
摘要
背景：孕妇在怀孕期间的焦虑可能会影响胎儿的免疫系统，从而导致儿童患哮喘的风险升高。有限的研究对产前焦虑与儿童哮喘之间的关系是否存在敏感期和累积效应进行了评估。
方法：本研究的样本来自中国马鞍山出生队列研究，共有3131对母婴。使用妊娠相关焦虑问卷在妊娠的第1、第2和第3个三个孕期重复三次评估母亲的焦虑状态。在婴儿出生后24个月、36个月和48个月时，收集儿童哮喘的诊断信息。
结果：调整混杂因素后，怀孕第一、第二和第三个月患有焦虑症的母亲所生的子女在12至48个月期间患哮喘的风险均较高。在进一步调整其他孕期产前焦虑后，未观察到任何孕期产前焦虑与学龄前儿童哮喘的关联。在妊娠期间焦虑评分持续较高的母亲的子女，患总哮喘和哮喘高发病率轨迹的风险升高。累积效应分析显示，母亲焦虑越频繁，子女从12到48个月高发病率哮喘的风险越高。年龄亚组分析的结果整体上显示类似的关联。
结论：产前期母亲焦虑与学龄前儿童哮喘的发病风险升高相关，可能存在累积效应。应持续关注孕期母亲的心理健康状况，而不仅仅是在孕期的某一时期。
Zhou, J. X., Guo, Y., Teng, Y. Z., Zhu, L. L., Lu, J., Hao, X. M., Yan, S. Q., Tao, F. B., & Huang, K.
Abstract
Background:The fetal immune system and consequent elevated risk of asthma in childhood may be impacted by maternal anxiety during pregnancy. Limited studies have evaluated whether there was a sensitive period and cumulative effect of the relationship between prenatal anxiety and children's asthma.
Methods:3131 mother-child pairs made up the study's sample from the Ma'anshan Birth Cohort Study in China. Maternal anxiety status was repeated three times using the pregnancy-related anxiety questionnaire in the 1st, 2nd and 3rd trimesters of pregnancy. Diagnostic information on asthma was collected three times at 24, 36, and 48 months of age.
Results:After adjusting for confounders, children born to mothers with anxiety in the 1st, 2nd and 3rd trimesters of pregnancy all had an elevated risk of total asthma from 12 to 48 months of age. After further adjusting prenatal anxiety in the other trimesters, no association was observed between prenatal anxiety in any trimester and preschoolers' asthma. Children of mothers with persistently high anxiety score trajectory during pregnancy had an elevated risk of total asthma and high prevalence trajectory of asthma. Cumulative effects analysis showed that the more frequent the mother's anxiety, the higher the risk of her offspring developing a high prevalence trajectory of asthma from 12 to 48 months of age. The results of the subgroup analysis by age showed similar associations overall. Conclusion:Maternal antenatal anxiety was associated with an elevated risk of preschool children's asthma, and a possible cumulative effect was observed. Maternal mental health conditions during pregnancy should receive constant attention throughout pregnancy, not just during one period.
背景：孕妇在怀孕期间的焦虑可能会影响胎儿的免疫系统，从而导致儿童患哮喘的风险升高。有限的研究对产前焦虑与儿童哮喘之间的关系是否存在敏感期和累积效应进行了评估。
方法：本研究的样本来自中国马鞍山出生队列研究，共有3131对母婴。使用妊娠相关焦虑问卷在妊娠的第1、第2和第3个三个孕期重复三次评估母亲的焦虑状态。在婴儿出生后24个月、36个月和48个月时，收集儿童哮喘的诊断信息。
结果：调整混杂因素后，怀孕第一、第二和第三个月患有焦虑症的母亲所生的子女在12至48个月期间患哮喘的风险均较高。在进一步调整其他孕期产前焦虑后，未观察到任何孕期产前焦虑与学龄前儿童哮喘的关联。在妊娠期间焦虑评分持续较高的母亲的子女，患总哮喘和哮喘高发病率轨迹的风险升高。累积效应分析显示，母亲焦虑越频繁，子女从12到48个月高发病率哮喘的风险越高。年龄亚组分析的结果整体上显示类似的关联。
结论：产前期母亲焦虑与学龄前儿童哮喘的发病风险升高相关，可能存在累积效应。应持续关注孕期母亲的心理健康状况，而不仅仅是在孕期的某一时期。
(中日友好医院呼吸与危重症医学科 沈焜路 摘译 林江涛 审校)
(J Affect Disord. 2023 Nov. DOI: 10.1016/j.jad.2023.08.037)
Maternal anxiety during pregnancy and children's asthma in preschool age: The Ma'anshan birth cohort study (J Affect Disord. 2023 Nov. DOI: 10.1016/j.jad.2023.08.037)
Zhou, J. X., Guo, Y., Teng, Y. Z., Zhu, L. L., Lu, J., Hao, X. M., Yan, S. Q., Tao, F. B., & Huang, K.
Abstract
Background:The fetal immune system and consequent elevated risk of asthma in childhood may be impacted by maternal anxiety during pregnancy. Limited studies have evaluated whether there was a sensitive period and cumulative effect of the relationship between prenatal anxiety and children's asthma.
Methods:3131 mother-child pairs made up the study's sample from the Ma'anshan Birth Cohort Study in China. Maternal anxiety status was repeated three times using the pregnancy-related anxiety questionnaire in the 1st, 2nd and 3rd trimesters of pregnancy. Diagnostic information on asthma was collected three times at 24, 36, and 48 months of age.
Results:After adjusting for confounders, children born to mothers with anxiety in the 1st, 2nd and 3rd trimesters of pregnancy all had an elevated risk of total asthma from 12 to 48 months of age. After further adjusting prenatal anxiety in the other trimesters, no association was observed between prenatal anxiety in any trimester and preschoolers' asthma. Children of mothers with persistently high anxiety score trajectory during pregnancy had an elevated risk of total asthma and high prevalence trajectory of asthma. Cumulative effects analysis showed that the more frequent the mother's anxiety, the higher the risk of her offspring developing a high prevalence trajectory of asthma from 12 to 48 months of age. The results of the subgroup analysis by age showed similar associations overall. Conclusion:Maternal antenatal anxiety was associated with an elevated risk of preschool children's asthma, and a possible cumulative effect was observed. Maternal mental health conditions during pregnancy should receive constant attention throughout pregnancy, not just during one period.
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2017-2019 年墨西哥城空气质量与哮喘相关急诊入院率之间的关系
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