过敏性鼻炎和哮喘控制与EQ-5D-5L结构域损害：一项MASK-air真实世界研究
2023/08/28
摘要
背景：EQ-5D-5L是一种广泛使用的与健康相关的生活质量工具，包括五个领域。然而，目前尚不清楚鼻炎或哮喘控制对每个领域的影响。
目的：使用MASK air®mHealth应用程序的数据评估鼻炎或哮喘控制与不同EQ-5D-5L结构域之间的关系。
方法：在这项横断面研究中，我们评估了所有MASK air®用户（2015-2021；24个国家）的数据。对于每个EQ-5D-5L结构域的水平，我们评估了鼻炎和哮喘视觉模拟量表（VAS）以及综合症状药物评分（CSMS）。我们建立了顺序多变量模型，评估VAS/CSMS值与每个EQ-5D-5L域的水平之间的调整关联。最后，我们比较了来自鼻炎和自我报告哮喘患者的EQ-5D-5L数据与来自单独鼻炎患者的数据。
结果：我们对3092名用户的5354天进行了评估。我们观察到鼻炎或哮喘的控制较差（VAS和CSMS较高）与EQ-5D-5L水平较差之间存在关联。在多变量模型中，所有VAS和CSMS都与较高水平的疼痛/不适和日常活动有关。对于焦虑/抑郁，这种关联主要在鼻炎相关工具（VAS鼻部、VAS全局和CSMS）中观察到，尽管自我报告的哮喘也与更严重的焦虑/抑郁有关。较差的行动能力（“四处走动”）尤其与VAS哮喘和哮喘的存在有关。
结论：更差的鼻炎控制和更差的哮喘控制与更高的EQ-5D-5L水平相关，特别是在疼痛/不适和活动障碍方面。鼻炎控制不佳与焦虑/抑郁加重有关，哮喘控制不佳与行动能力较差有关。
Impairment of EQ-5D-5L domains according to allergic rhinitis and asthma control: A MASK-air real-world study
Bernardo Sousa-Pinto, Gilles Louis, Jorge Rodrigues, Antonio Francesco Maria Giuliano, Ilaria Baiardini, Fulvio Braido, Wienczyslawa Czarlewski
Abstract
Background: EQ-5D-5L is a widely used health-related quality-of-life instrument, comprising five domains. However, it is not known how each domain is impacted by rhinitis or asthma control.
Objective: To assess the association between rhinitis or asthma control and the different EQ-5D-5L domains using data from the MASK-air® mHealth app.
Methods: In this cross-sectional study, we assessed data from all MASK-air® users (2015-2021; 24 countries). For the levels of each EQ-5D-5L domain, we assessed rhinitis and asthma visual analog scales (VASs) and the combined symptom-medication score (CSMS). We built ordinal multivariable models assessing the adjusted association between VAS/CSMS values and the levels of each EQ-5D-5L domain. Finally, we compared EQ-5D-5L data from users with rhinitis and self-reported asthma with data from users with rhinitis alone.
Results: We assessed 5354 days from 3092 users. We observed an association between worse control of rhinitis or asthma (higher VASs and CSMS) and worse EQ-5D-5L levels. In multivariable models, all VASs and the CSMS were associated with higher levels of pain/discomfort and daily activities. For anxiety/depression, the association was mostly observed for rhinitis-related tools (VAS nose, VAS global and CSMS), although the presence of self-reported asthma was also associated with worse anxiety/depression. Worse mobility ("walking around") was particularly associated with VAS asthma and with the presence of asthma.
Conclusion: A worse rhinitis control and a worse asthma control are associated with higher EQ-5D-5L levels, particularly regarding pain/discomfort and activities impairment. Worse rhinitis control is associated with worse anxiety/depression, and poor asthma control with worse mobility.
背景：EQ-5D-5L是一种广泛使用的与健康相关的生活质量工具，包括五个领域。然而，目前尚不清楚鼻炎或哮喘控制对每个领域的影响。
目的：使用MASK air®mHealth应用程序的数据评估鼻炎或哮喘控制与不同EQ-5D-5L结构域之间的关系。
方法：在这项横断面研究中，我们评估了所有MASK air®用户（2015-2021；24个国家）的数据。对于每个EQ-5D-5L结构域的水平，我们评估了鼻炎和哮喘视觉模拟量表（VAS）以及综合症状药物评分（CSMS）。我们建立了顺序多变量模型，评估VAS/CSMS值与每个EQ-5D-5L域的水平之间的调整关联。最后，我们比较了来自鼻炎和自我报告哮喘患者的EQ-5D-5L数据与来自单独鼻炎患者的数据。
结果：我们对3092名用户的5354天进行了评估。我们观察到鼻炎或哮喘的控制较差（VAS和CSMS较高）与EQ-5D-5L水平较差之间存在关联。在多变量模型中，所有VAS和CSMS都与较高水平的疼痛/不适和日常活动有关。对于焦虑/抑郁，这种关联主要在鼻炎相关工具（VAS鼻部、VAS全局和CSMS）中观察到，尽管自我报告的哮喘也与更严重的焦虑/抑郁有关。较差的行动能力（“四处走动”）尤其与VAS哮喘和哮喘的存在有关。
结论：更差的鼻炎控制和更差的哮喘控制与更高的EQ-5D-5L水平相关，特别是在疼痛/不适和活动障碍方面。鼻炎控制不佳与焦虑/抑郁加重有关，哮喘控制不佳与行动能力较差有关。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(J Allergy Clin Immunol Pract. 2023 Aug 10;S2213-2198(23)00906-6. doi: 10.1016/j.jaip.2023.08.006.)
(J Allergy Clin Immunol Pract. 2023 Aug 10;S2213-2198(23)00906-6. doi: 10.1016/j.jaip.2023.08.006.)
Impairment of EQ-5D-5L domains according to allergic rhinitis and asthma control: A MASK-air real-world study
Bernardo Sousa-Pinto, Gilles Louis, Jorge Rodrigues, Antonio Francesco Maria Giuliano, Ilaria Baiardini, Fulvio Braido, Wienczyslawa Czarlewski
Abstract
Background: EQ-5D-5L is a widely used health-related quality-of-life instrument, comprising five domains. However, it is not known how each domain is impacted by rhinitis or asthma control.
Objective: To assess the association between rhinitis or asthma control and the different EQ-5D-5L domains using data from the MASK-air® mHealth app.
Methods: In this cross-sectional study, we assessed data from all MASK-air® users (2015-2021; 24 countries). For the levels of each EQ-5D-5L domain, we assessed rhinitis and asthma visual analog scales (VASs) and the combined symptom-medication score (CSMS). We built ordinal multivariable models assessing the adjusted association between VAS/CSMS values and the levels of each EQ-5D-5L domain. Finally, we compared EQ-5D-5L data from users with rhinitis and self-reported asthma with data from users with rhinitis alone.
Results: We assessed 5354 days from 3092 users. We observed an association between worse control of rhinitis or asthma (higher VASs and CSMS) and worse EQ-5D-5L levels. In multivariable models, all VASs and the CSMS were associated with higher levels of pain/discomfort and daily activities. For anxiety/depression, the association was mostly observed for rhinitis-related tools (VAS nose, VAS global and CSMS), although the presence of self-reported asthma was also associated with worse anxiety/depression. Worse mobility ("walking around") was particularly associated with VAS asthma and with the presence of asthma.
Conclusion: A worse rhinitis control and a worse asthma control are associated with higher EQ-5D-5L levels, particularly regarding pain/discomfort and activities impairment. Worse rhinitis control is associated with worse anxiety/depression, and poor asthma control with worse mobility.
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