支气管热成形术治疗超重/肥胖和低生活质量哮喘患者的疗效
2023/05/25
摘要
背景：支气管热成形术(BT)对部分重症哮喘患者有效;然而，对BT产生良好反应的特定哮喘表型尚未完全了解。
方法：回顾性分析了在日本一家机构接受BT治疗的严重哮喘患者的临床资料。
结果：随访评估时，哮喘生活质量问卷(AQLQ)评分(P=0.003)、维持口服皮质类固醇剂量(P=0.027)和加重频率(P=0.017)均显著改善，而支气管扩张剂前1秒用力呼气量(预测%)无显著变化(P=0.19)。根据体重指数水平将患者分为两组，超重/肥胖患者AQLQ评分明显高于体重正常患者(P=0.01)。
结论：本研究表明，表现出超重/肥胖和低生活质量的非控制的严重哮喘患者从BT中可获得潜在的益处。
Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/ obesity and low quality of life
K. Nishi, C. Yoshimura, K. Morita, R. Ishikawa, E. Toyokura, T. Nagasaki, et al
Abtract
BACKGROUND:Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood.
METHODS:Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan.
RESULTS: At the follow-up assessment, the Asthma Quality of Life Questionnaire (AQLQ) scores (P=0.003), maintenance oral corticosteroid doses (P=0.027), and exacerbation frequency (P =0.017) were significantly improved, while prebronchodilator-forced expiratory volume in 1 second (% predicted) did not significantly change (P =0.19). When we grouped the patients into 2 groups according to their body mass index levels, the AQLQ scores were more improved in patients with overweight/obesity than those with normal weight (P =0.01).
CONCLUSIONS: This study showed that patients with non-controlled severe asthma exhibiting overweight /obesity and low quality of life had potential benefits from BT.
背景：支气管热成形术(BT)对部分重症哮喘患者有效;然而，对BT产生良好反应的特定哮喘表型尚未完全了解。
方法：回顾性分析了在日本一家机构接受BT治疗的严重哮喘患者的临床资料。
结果：随访评估时，哮喘生活质量问卷(AQLQ)评分(P=0.003)、维持口服皮质类固醇剂量(P=0.027)和加重频率(P=0.017)均显著改善，而支气管扩张剂前1秒用力呼气量(预测%)无显著变化(P=0.19)。根据体重指数水平将患者分为两组，超重/肥胖患者AQLQ评分明显高于体重正常患者(P=0.01)。
结论：本研究表明，表现出超重/肥胖和低生活质量的非控制的严重哮喘患者从BT中可获得潜在的益处。
（中日友好医院呼吸与危重症医学科 李春晓 摘译 林江涛 审校）
（World Allergy Organization Journal, 2023, 16(3).DOI: ARTN 10075610.1016/j.waojou.2023.100756）
（World Allergy Organization Journal, 2023, 16(3).DOI: ARTN 10075610.1016/j.waojou.2023.100756）
Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/ obesity and low quality of life
K. Nishi, C. Yoshimura, K. Morita, R. Ishikawa, E. Toyokura, T. Nagasaki, et al
Abtract
BACKGROUND:Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood.
METHODS:Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan.
RESULTS: At the follow-up assessment, the Asthma Quality of Life Questionnaire (AQLQ) scores (P=0.003), maintenance oral corticosteroid doses (P=0.027), and exacerbation frequency (P =0.017) were significantly improved, while prebronchodilator-forced expiratory volume in 1 second (% predicted) did not significantly change (P =0.19). When we grouped the patients into 2 groups according to their body mass index levels, the AQLQ scores were more improved in patients with overweight/obesity than those with normal weight (P =0.01).
CONCLUSIONS: This study showed that patients with non-controlled severe asthma exhibiting overweight /obesity and low quality of life had potential benefits from BT.
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