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腹部和全身肥胖与呼吸道症状、哮喘和慢性阻塞性肺疾病的相关性分析:来自RHINE研究结果

2023/03/21

   摘要
   背景:先前关于腹部和全身肥胖与呼吸系统疾病之间相关性分析的研究结果相互矛盾。本研究旨在探索女性和男性中无全身肥胖的腹部肥胖与呼吸系统症状、哮喘和慢性阻塞性肺病的相关性。
   方法:本横断面研究基于2010-2012年进行的北欧呼吸健康(RHINE)III问卷(n=1290)。腹部肥胖是使用性别特异性标准界值自行测量的腰围:男性≥102cm,女性≥88cm。全身肥胖定义为自我报告的BMI≥30.0kg/m2
   结果:本研究共纳入4261名腹部肥胖受试者(63%为女性),1837名全身肥胖受试者(50%为女性)。腹部肥胖和全身肥胖各自独立,并与呼吸道症状相关(比值比(OR)为1.25-2.00)。哮喘与女性腹部肥胖和全身肥胖显著相关,OR(95%CI)分别为1.56(1.30-1.87)和1.95(1.56-2.43),但与男性无关,OR分别为1.22(0.97-3.17)和1.28(0.97-1.68)。自我报告的慢性阻塞性肺疾病也存在类似的性别差异。
   结论:全身肥胖和腹部肥胖是与成人呼吸道症状相关的独立因素。哮喘和慢性阻塞性肺疾病与女性腹部肥胖和全身肥胖独立相关,但与男性无关。

 
(中日友好医院呼吸与危重症医学科 张婧媛 摘译 林江涛 审校)
(Respir Med. 2023 Mar 16:107213. doi: 10.1016/j.rmed.2023.107213.)

 
Association between abdominal and general obesity and respiratory symptoms, asthma and COPD. Results from the RHINE study.
 
Kisiel MA, Arnfelt O, Lindberg E, Jogi O, Malinovschi A, Johannessen A, Benediktsdottir B, Franklin K, Holm M, Real FG, Sigsgaard T, Gislason T, Modig L, Janson C.
 
Abstract
BACKGROUND:Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic  obstructive pulmonary disease independently from general obesity in women and men.
METHODS:This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010-2012. Abdominal obesity was self-measured waist circumference using a sex-specific standard cut-off point: ≥102 cm in males and ≥88 cm in females. General obesity was defined as self-reported BMI ≥30.0 kg/m2.
RESULTS:There were 4261 subjects (63% women) with abdominal obesity and 1837 subjects (50% women) with general obesity. Both abdominal and general obesity was independent of each other and associated with respiratory symptoms (odds ratio (OR) from 1.25 to 2.00)). Asthma was significantly associated with abdominal and general obesity in women, OR (95% CI) 1.56 (1.30-1.87) and 1.95 (1.56-2.43), respectively, but not in men, OR 1.22 (0.97-3.17) and 1.28 (0.97-1.68) respectively. A similar sex difference was found for self-reported chronic obstructive pulmonary disease.
CONCLUSIONS:General and abdominal obesity were independent factors associated with respiratory symptoms in adults. Asthma and chronic obstructive pulmonary disease were independently linked to abdominal and general obesity in women but not men.




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