非严重哮喘成人血浆胸腺基质淋巴细胞生成素（TSLP）：EGEA研究
2022/12/21
摘要
胸腺基质淋巴生成素（TSLP）是一种参与严重哮喘治疗的细胞因子，从未在非严重哮喘中进行过研究。在一项大型流行病学研究的969名成年人中，横断面分析显示，血浆TSLP水平与年龄和BMI、男性、吸烟以及TSLP水平高（一个IQR增加）、当前哮喘和肺功能不良相关。高TSLP水平也与10年后哮喘发作的持续性[aOR=2.14（95%CI 1.23至3.72）]和呼吸困难[aOR=2.71（95%CI 1.39至5.28）]相关。我们的结果表明，TSLP可能是非严重哮喘患者有研究价值的细胞因子，在哮喘管理中可以考虑其循环水平的决定因素。
Plasma thymic stromal lymphopoietin (TSLP) in adults with non-severe asthma: the EGEA study
Bakari Ibrahim, Djamal Achour, Farid Zerimech, Patricia de Nadai, Valerie Siroux, Anne Tsicopoulos, Régis Matran, Vanessa Granger, Rachel Nadif
Abstract
Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma. Among 969 adults from a large epidemiological study, cross-sectional analyses showed that plasma TSLP levels were associated with increased age and BMI, male sex, smoking and high TSLP levels (one IQR increase) with current asthma and poor lung function. High TSLP levels were also associated with persistence of asthma attacks (aOR=2.14 (95% CI 1.23 to 3.72)) and dyspnoea (aOR=2.71 (95% CI 1.39 to 5.28)) 10 years later. Our results suggest that TSLP could be a cytokine of interest in non-severe asthma, and its determinants of circulating levels could be considered in asthma management.
胸腺基质淋巴生成素（TSLP）是一种参与严重哮喘治疗的细胞因子，从未在非严重哮喘中进行过研究。在一项大型流行病学研究的969名成年人中，横断面分析显示，血浆TSLP水平与年龄和BMI、男性、吸烟以及TSLP水平高（一个IQR增加）、当前哮喘和肺功能不良相关。高TSLP水平也与10年后哮喘发作的持续性[aOR=2.14（95%CI 1.23至3.72）]和呼吸困难[aOR=2.71（95%CI 1.39至5.28）]相关。我们的结果表明，TSLP可能是非严重哮喘患者有研究价值的细胞因子，在哮喘管理中可以考虑其循环水平的决定因素。
(中日友好医院呼吸与危重症医学科 李红雯 摘译 林江涛 审校)
(Thorax. 2022 Dec 14; thoraxjnl-2022-219192. doi: 10.1136/thorax-2022-219192.)
(Thorax. 2022 Dec 14; thoraxjnl-2022-219192. doi: 10.1136/thorax-2022-219192.)
Plasma thymic stromal lymphopoietin (TSLP) in adults with non-severe asthma: the EGEA study
Bakari Ibrahim, Djamal Achour, Farid Zerimech, Patricia de Nadai, Valerie Siroux, Anne Tsicopoulos, Régis Matran, Vanessa Granger, Rachel Nadif
Abstract
Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma. Among 969 adults from a large epidemiological study, cross-sectional analyses showed that plasma TSLP levels were associated with increased age and BMI, male sex, smoking and high TSLP levels (one IQR increase) with current asthma and poor lung function. High TSLP levels were also associated with persistence of asthma attacks (aOR=2.14 (95% CI 1.23 to 3.72)) and dyspnoea (aOR=2.71 (95% CI 1.39 to 5.28)) 10 years later. Our results suggest that TSLP could be a cytokine of interest in non-severe asthma, and its determinants of circulating levels could be considered in asthma management.
上一篇：
厚朴麻黄汤对哮喘患者血清代谢及TRPV1/Ca2+/TJs的影响
下一篇：
LTβR信号直接控制气道平滑肌失调和哮喘肺功能障碍
