成年患者自我相关依从性、哮喘相关生活质量与哮喘控制的相关性
2021/07/28
摘要
目的：药物不依从性主要发生在疾病严重程度范围广泛的患者中，包括哮喘。该研究的目的是评估自我报告的哮喘治疗依从性，并调查依从性、哮喘控制和哮喘相关生活质量之间的关系。
方法：该研究是一项横断面研究，参与者从泗水一家医院的门诊招募。包括曾使用任何常规哮喘药物的哮喘患者（年龄≥18岁）。使用了标准化问卷，包括Juniper的哮喘控制问卷(ACQ)、对补充剂和药物的依从性量表(ARMS)和Juniper的哮喘生活质量问卷(AQLQ)。
结果：该研究共招募了82名患有哮喘的成年人。男性参与者的平均年龄为49.13±14.10岁（n=23）。大约59名参与者(72.0%)是女性，30名参与者(36.5%)使用布地奈德吸入器，73名参与者(89.0%) 从不吸烟。 ACQ、AQLQ和ARMS评分的平均值分别为1.62±1.19、4.96±1.24和16.98±4.12。在所研究的82名患者中，53名(64.6%)患有“无法控制的哮喘”，超过85%的参与者都对哮喘治疗表现出“不依从性”，其中近46%的人表示他们的生活质量受到哮喘的影响。ACQ和AQLQ 之间存在显着关联（p<0.05），而ACQ和ARMS之间没有发现统计学上显着的关联。
结论：大多数患者存在哮喘药物治疗的不依从。哮喘控制不佳与哮喘相关的生活质量降低有关。
The correlation between self-related adherence, asthma-related quality of life and control of asthma in adult patients
Zairina E, Nugraheni G, Achmad GNV, et al.
Abstract
OBJECTIVE: Medication non-adherence mostly occurs in patients with a wide range of disease severity, including asthma. The aim of the study was to assess the self reported adherence to asthma therapy and investigate the relationship between adherence, asthma control and asthma-related quality of life.
METHODS: The study was a cross-sectional study in which participants were recruited from an outpatient department, in one hospital in Surabaya. Patients (aged≥18 years) with asthma who had used any regular asthma medications were included. Standardized questionnaires, including Juniper’s Asthma Control Questionnaire (ACQ), Adherence to Refills and Medications Scales (ARMS) and Juniper’s Asthma Quality of Life Questionnaire (AQLQ) were used.
RESULTS:A total of 82 adults with asthma were recruited in the study. Male participants’ mean age was 49.13±14.10years(n=23). Approximately 59 participants (72.0%) were females, 30 participants (36.5%) were using Budesonide inhaler, and 73 participants (89.0%) never smoked. The mean of ACQ, AQLQ, and ARMS scores were 1.62±1.19,4.96±1.24, and 16.98±4.12, respectively. Of 82 patients studied 53 (64.6 %) had “uncontrolled asthma” and more than 85% participants both showed “non adherence” to asthma therapy and nearly 46% of them indicated that their quality of life was affected by asthma. There was a significant association between ACQ and AQLQ (p<0.05), whereas no statistically significant association was found between ACQ and ARMS.
CONCLUSIONS: The majority of patients reported non-adherence to asthma medications. Poor controlled asthma has been associated with lower asthma-related quality of life.
目的：药物不依从性主要发生在疾病严重程度范围广泛的患者中，包括哮喘。该研究的目的是评估自我报告的哮喘治疗依从性，并调查依从性、哮喘控制和哮喘相关生活质量之间的关系。
方法：该研究是一项横断面研究，参与者从泗水一家医院的门诊招募。包括曾使用任何常规哮喘药物的哮喘患者（年龄≥18岁）。使用了标准化问卷，包括Juniper的哮喘控制问卷(ACQ)、对补充剂和药物的依从性量表(ARMS)和Juniper的哮喘生活质量问卷(AQLQ)。
结果：该研究共招募了82名患有哮喘的成年人。男性参与者的平均年龄为49.13±14.10岁（n=23）。大约59名参与者(72.0%)是女性，30名参与者(36.5%)使用布地奈德吸入器，73名参与者(89.0%) 从不吸烟。 ACQ、AQLQ和ARMS评分的平均值分别为1.62±1.19、4.96±1.24和16.98±4.12。在所研究的82名患者中，53名(64.6%)患有“无法控制的哮喘”，超过85%的参与者都对哮喘治疗表现出“不依从性”，其中近46%的人表示他们的生活质量受到哮喘的影响。ACQ和AQLQ 之间存在显着关联（p<0.05），而ACQ和ARMS之间没有发现统计学上显着的关联。
结论：大多数患者存在哮喘药物治疗的不依从。哮喘控制不佳与哮喘相关的生活质量降低有关。
（中日友好医院呼吸与危重症医学科 李春晓 摘译 林江涛 审校）
（J Basic Clin Physiol Pharmacol 2021; 32(4): 453–458）
（J Basic Clin Physiol Pharmacol 2021; 32(4): 453–458）
The correlation between self-related adherence, asthma-related quality of life and control of asthma in adult patients
Zairina E, Nugraheni G, Achmad GNV, et al.
Abstract
OBJECTIVE: Medication non-adherence mostly occurs in patients with a wide range of disease severity, including asthma. The aim of the study was to assess the self reported adherence to asthma therapy and investigate the relationship between adherence, asthma control and asthma-related quality of life.
METHODS: The study was a cross-sectional study in which participants were recruited from an outpatient department, in one hospital in Surabaya. Patients (aged≥18 years) with asthma who had used any regular asthma medications were included. Standardized questionnaires, including Juniper’s Asthma Control Questionnaire (ACQ), Adherence to Refills and Medications Scales (ARMS) and Juniper’s Asthma Quality of Life Questionnaire (AQLQ) were used.
RESULTS:A total of 82 adults with asthma were recruited in the study. Male participants’ mean age was 49.13±14.10years(n=23). Approximately 59 participants (72.0%) were females, 30 participants (36.5%) were using Budesonide inhaler, and 73 participants (89.0%) never smoked. The mean of ACQ, AQLQ, and ARMS scores were 1.62±1.19,4.96±1.24, and 16.98±4.12, respectively. Of 82 patients studied 53 (64.6 %) had “uncontrolled asthma” and more than 85% participants both showed “non adherence” to asthma therapy and nearly 46% of them indicated that their quality of life was affected by asthma. There was a significant association between ACQ and AQLQ (p<0.05), whereas no statistically significant association was found between ACQ and ARMS.
CONCLUSIONS: The majority of patients reported non-adherence to asthma medications. Poor controlled asthma has been associated with lower asthma-related quality of life.
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Tezepelumab治疗重症未控制哮喘和常年性过敏患者的疗效
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