TIPE2在哮喘中的神秘作用
2021/06/18
摘要
与肿瘤坏死因子（TNF）-α诱导蛋白8（TNFAIP8/TIPE）家族中发挥致癌作用和调节细胞凋亡的其他成员不同，TNFAIP8-like2（TIPE2）不仅能维持免疫稳态，还能调节炎症。TIPE2主要抑制T细胞受体TCR和Toll样受体TLR的激活，调节其下游信号通路，从而调节炎症。有趣的是，TIPE2在许多炎症性疾病中异常表达，并可能促进或抑制不同疾病中的炎症。本文综述了TIPE2在免疫细胞和炎症性疾病中的分子靶点和细胞功能，以及TIPE2调节炎症的潜在机制。并详细阐述了TIPE2在哮喘中的作用及机制。TIPE2在哮喘中异常表达，通过调节多种炎症细胞的活性和功能参与不同表型哮喘的发病。考虑到TIPE2可能是哮喘的有效治疗靶点。然而，现有数据不足以全面了解TIPE2在人类哮喘中的复杂作用。仍需进一步研究探讨TIPE2在不同哮喘表型中可能的作用机制。
The enigmatic role of TIPE2 in asthma
Bingqing Shi, Yuqiu Hao , Wei Li , Hongna Dong , Mengting Xu , Peng Gao
Abstract
Unlike other members of the tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8/TIPE) family that play a carcinogenic role and regulate apoptosis, TNFAIP8-like 2 (TIPE2) can not only maintain immune homeostasis but also regulate inflammation. TIPE2 mainly restrains the activation of T cell receptor (TCR) and Toll-like receptors (TLR), regulating its downstream signaling pathways, thereby regulating inflammation. Interestingly, TIPE2 is abnormally expressed in many inflammatory diseases and may promote or inhibit inflammation in different diseases. This review summarizes the molecular target and cellular function of TIPE2 in immune cells and inflammatory diseases and the underlying mechanism by which TIPE2 regulates inflammation. The function and mechanism of TIPE2 in asthma is also explained in detail. TIPE2 is abnormally expressed in asthma and participates in the pathogenesis of different phenotypes of asthma through regulating multiple inflammatory cells' activity and function. Considering the indispensable role of TIPE2 in asthma, TIPE2 may be an effective therapeutic target in asthma. However, the available data are insufficient to provide a full understanding of the complex role of TIPE2 in human asthma. Further study is still necessary to explore the possible mechanism and functions of TIPE2 in different asthma phenotypes.
与肿瘤坏死因子（TNF）-α诱导蛋白8（TNFAIP8/TIPE）家族中发挥致癌作用和调节细胞凋亡的其他成员不同，TNFAIP8-like2（TIPE2）不仅能维持免疫稳态，还能调节炎症。TIPE2主要抑制T细胞受体TCR和Toll样受体TLR的激活，调节其下游信号通路，从而调节炎症。有趣的是，TIPE2在许多炎症性疾病中异常表达，并可能促进或抑制不同疾病中的炎症。本文综述了TIPE2在免疫细胞和炎症性疾病中的分子靶点和细胞功能，以及TIPE2调节炎症的潜在机制。并详细阐述了TIPE2在哮喘中的作用及机制。TIPE2在哮喘中异常表达，通过调节多种炎症细胞的活性和功能参与不同表型哮喘的发病。考虑到TIPE2可能是哮喘的有效治疗靶点。然而，现有数据不足以全面了解TIPE2在人类哮喘中的复杂作用。仍需进一步研究探讨TIPE2在不同哮喘表型中可能的作用机制。
(中日友好医院呼吸与危重症医学科 张清 摘译 林江涛 审校)
(Am J Physiol Lung Cell Mol Physiol. 2020 Jul 1;319(1):L163-L172.doi: 10.1152/ajplung.00069.2020.)
(Am J Physiol Lung Cell Mol Physiol. 2020 Jul 1;319(1):L163-L172.doi: 10.1152/ajplung.00069.2020.)
The enigmatic role of TIPE2 in asthma
Bingqing Shi, Yuqiu Hao , Wei Li , Hongna Dong , Mengting Xu , Peng Gao
Abstract
Unlike other members of the tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8/TIPE) family that play a carcinogenic role and regulate apoptosis, TNFAIP8-like 2 (TIPE2) can not only maintain immune homeostasis but also regulate inflammation. TIPE2 mainly restrains the activation of T cell receptor (TCR) and Toll-like receptors (TLR), regulating its downstream signaling pathways, thereby regulating inflammation. Interestingly, TIPE2 is abnormally expressed in many inflammatory diseases and may promote or inhibit inflammation in different diseases. This review summarizes the molecular target and cellular function of TIPE2 in immune cells and inflammatory diseases and the underlying mechanism by which TIPE2 regulates inflammation. The function and mechanism of TIPE2 in asthma is also explained in detail. TIPE2 is abnormally expressed in asthma and participates in the pathogenesis of different phenotypes of asthma through regulating multiple inflammatory cells' activity and function. Considering the indispensable role of TIPE2 in asthma, TIPE2 may be an effective therapeutic target in asthma. However, the available data are insufficient to provide a full understanding of the complex role of TIPE2 in human asthma. Further study is still necessary to explore the possible mechanism and functions of TIPE2 in different asthma phenotypes.
