婴儿期鼻咽微生物群的发育模式与哮喘风险相关
2020/11/17
摘要
背景：研究表明，鼻腔微生物群可能与儿童哮喘的存在或未来风险密切相关。
目的：本研究检测了生命早期鼻咽微生物群的发育轨迹和疾病期间的微生物群的组成是否与儿童哮喘发病风险相关。
方法：参加“儿童哮喘起源研究”的儿童(n=285)在出生后头两年，常规健康检查(2、4、6、9、12、18和24月龄)和呼吸道疾病发作期间提供鼻咽粘液样本，并对该样本进行呼吸道病毒和细菌分析。我们确定了生命早期微生物群组成的发育轨迹，以及呼吸系统疾病期间的主要细菌，并将其与6、8、11、13和18岁时哮喘的存在相关联。
结果：在已确定的四种微生物群轨迹中，在生命的前6个月以葡萄球菌占优势的微生物群与3岁前反复喘息和持续整个儿童期哮喘的风险增加有关。此外，该轨迹与变态反应致敏的早期发作有关。在喘息性疾病中，鼻病毒的检测和莫拉氏菌占优势与整个童年后期持续存在的哮喘有关。
结论：在婴儿期，健康时期的微生物群发育组成和急性喘息性疾病时的优势菌群均与随后发生持续性儿童哮喘的风险相关。
Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk
Howard H F Tang, Anna Lang, Shu Mei Teo, Louise M Judd, Ronald Gangnon, Michael D Evans, Kristine E Lee, Rose Vrtis, Patrick G Holt, Robert F Lemanske Jr, Daniel J Jackson, Kathryn E Holt, Michael Inouye, James E Gern.
Abstract
Background:Studies indicate that the nasal microbiome may correlate strongly with the presence or future risk of childhood asthma.
Objectives:In this study, we tested whether developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses were related to risk of childhood asthma.
Methods:Children participating in the Childhood Origins of Asthma study (n=285) provided nasopharyngeal mucus samples in the first two years of life, during routine healthy study visits (2, 4, 6, 9, 12, 18 and 24 months of age) and episodes of respiratory illnesses, which were analyzed for respiratory viruses and bacteria. We identified developmental trajectories of early-life microbiome composition, as well as predominant bacteria during respiratory illnesses, and correlated these with presence of asthma at 6, 8, 11, 13 and 18 years of age.
Results:Of the four microbiome trajectories identified, a Staphylococcus-dominant microbiome in the first 6 months of life was associated with increased risk of recurrent wheezing by age 3 years and asthma that persisted throughout childhood. In addition, this trajectory was associated with the early onset of allergic sensitization. During wheezing illnesses, detection of rhinoviruses and predominance of Moraxella were associated with asthma that persisted throughout later childhood.
Conclusion:In infancy, the developmental composition of the microbiome during healthy periods and the predominant microbes during acute wheezing illnesses are both associated with the subsequent risk of developing persistent childhood asthma.
背景：研究表明，鼻腔微生物群可能与儿童哮喘的存在或未来风险密切相关。
目的：本研究检测了生命早期鼻咽微生物群的发育轨迹和疾病期间的微生物群的组成是否与儿童哮喘发病风险相关。
方法：参加“儿童哮喘起源研究”的儿童(n=285)在出生后头两年，常规健康检查(2、4、6、9、12、18和24月龄)和呼吸道疾病发作期间提供鼻咽粘液样本，并对该样本进行呼吸道病毒和细菌分析。我们确定了生命早期微生物群组成的发育轨迹，以及呼吸系统疾病期间的主要细菌，并将其与6、8、11、13和18岁时哮喘的存在相关联。
结果：在已确定的四种微生物群轨迹中，在生命的前6个月以葡萄球菌占优势的微生物群与3岁前反复喘息和持续整个儿童期哮喘的风险增加有关。此外，该轨迹与变态反应致敏的早期发作有关。在喘息性疾病中，鼻病毒的检测和莫拉氏菌占优势与整个童年后期持续存在的哮喘有关。
结论：在婴儿期，健康时期的微生物群发育组成和急性喘息性疾病时的优势菌群均与随后发生持续性儿童哮喘的风险相关。
(中日友好医院呼吸与危重症医学科 王静茹 摘译 林江涛 审校)
(J Allergy Clin Immunol. 2020 Oct 19;S0091-6749(20)31416-0. doi: 10.1016/j.jaci.2020.10.009.)
(J Allergy Clin Immunol. 2020 Oct 19;S0091-6749(20)31416-0. doi: 10.1016/j.jaci.2020.10.009.)
Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk
Howard H F Tang, Anna Lang, Shu Mei Teo, Louise M Judd, Ronald Gangnon, Michael D Evans, Kristine E Lee, Rose Vrtis, Patrick G Holt, Robert F Lemanske Jr, Daniel J Jackson, Kathryn E Holt, Michael Inouye, James E Gern.
Abstract
Background:Studies indicate that the nasal microbiome may correlate strongly with the presence or future risk of childhood asthma.
Objectives:In this study, we tested whether developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses were related to risk of childhood asthma.
Methods:Children participating in the Childhood Origins of Asthma study (n=285) provided nasopharyngeal mucus samples in the first two years of life, during routine healthy study visits (2, 4, 6, 9, 12, 18 and 24 months of age) and episodes of respiratory illnesses, which were analyzed for respiratory viruses and bacteria. We identified developmental trajectories of early-life microbiome composition, as well as predominant bacteria during respiratory illnesses, and correlated these with presence of asthma at 6, 8, 11, 13 and 18 years of age.
Results:Of the four microbiome trajectories identified, a Staphylococcus-dominant microbiome in the first 6 months of life was associated with increased risk of recurrent wheezing by age 3 years and asthma that persisted throughout childhood. In addition, this trajectory was associated with the early onset of allergic sensitization. During wheezing illnesses, detection of rhinoviruses and predominance of Moraxella were associated with asthma that persisted throughout later childhood.
Conclusion:In infancy, the developmental composition of the microbiome during healthy periods and the predominant microbes during acute wheezing illnesses are both associated with the subsequent risk of developing persistent childhood asthma.
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气候因素和空气质量指数之间的相互作用改善儿童哮喘自我管理
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哮喘和慢性阻塞性肺病并非SARS-CoV-2感染病例ICU住院和死亡的危险因素
