哮喘：从免疫机制到精准医学
2020/09/17
摘要
哮喘的多种特征性性免疫机制（内型）决定了其不同的临床表现（表型）。内型机制的鉴别对于更好地描述患者特征和确定个体化的针对特定免疫途径的新型生物制剂治疗方案是至关重要。本文综述了哮喘发病机制中的主要免疫学机制，并讨论了哮喘表型特征的出现。本文讨论了新的生物制剂和其他针对特定内型的药物，它们的使用代表了一种精准的疾病治疗方法，这也是目前对更严重的病人的治疗所强调的。
Asthma from immune pathogenesis to precision medicine.
Kareem Khalaf ,Giovanni Paoletti ,Francesca Puggioni ,Francesca Racca ,Fabrizio De Luca ,Veronica Giorgis ,Giorgio Walter Canonica ,Enrico Heffler.
Abstract
Asthma is characterized by multiple immunological mechanisms (endotypes) determining variable clinical presentations (phenotypes). The identification of endotypic mechanisms is crucial to better characterize patients and to identify tailored therapeutic approaches with novel biological agents targeting specific immunological pathways. This review focused on summarizing the major immunological mechanisms involved in the pathogenesis of asthma, as well as on discussing the emergence of phenotypic features of the disease. Novel biological agents and other drugs targeting specific endotypes are discussed, as their use represent a precision medicine approach to the disease that is nowadays mandatory particularly for treating more severe patients.
哮喘的多种特征性性免疫机制（内型）决定了其不同的临床表现（表型）。内型机制的鉴别对于更好地描述患者特征和确定个体化的针对特定免疫途径的新型生物制剂治疗方案是至关重要。本文综述了哮喘发病机制中的主要免疫学机制，并讨论了哮喘表型特征的出现。本文讨论了新的生物制剂和其他针对特定内型的药物，它们的使用代表了一种精准的疾病治疗方法，这也是目前对更严重的病人的治疗所强调的。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Semin Immunol,2019 Dec;46:101294. doi: 10.1016/j.smim.2019.101294. Epub 2019 Aug 3.)
(Semin Immunol,2019 Dec;46:101294. doi: 10.1016/j.smim.2019.101294. Epub 2019 Aug 3.)
Asthma from immune pathogenesis to precision medicine.
Kareem Khalaf ,Giovanni Paoletti ,Francesca Puggioni ,Francesca Racca ,Fabrizio De Luca ,Veronica Giorgis ,Giorgio Walter Canonica ,Enrico Heffler.
Abstract
Asthma is characterized by multiple immunological mechanisms (endotypes) determining variable clinical presentations (phenotypes). The identification of endotypic mechanisms is crucial to better characterize patients and to identify tailored therapeutic approaches with novel biological agents targeting specific immunological pathways. This review focused on summarizing the major immunological mechanisms involved in the pathogenesis of asthma, as well as on discussing the emergence of phenotypic features of the disease. Novel biological agents and other drugs targeting specific endotypes are discussed, as their use represent a precision medicine approach to the disease that is nowadays mandatory particularly for treating more severe patients.
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嗜酸粒细胞性哮喘
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每日一次莫米松加吲达特罗与莫米松或每日两次氟替卡松加沙美特罗治疗哮喘控制不佳患者的比较(PALLADIUM)：一项随机、
