儿童期哮喘的独特免疫表型
2020/08/20
摘要
早起暴露于环境触发因素可能会通过免疫应答失调而诱发慢性炎症性疾病。为了厘清早期免疫功能与儿童期哮喘发作之间的关系，我们对541名18月龄婴儿的血液的186项参数进行功能性免疫分析，并研究了其对应答表型与6岁时短暂或持续性疾病发作之间的联系。中性粒细胞相关的抗病毒应答异常与短暂性哮喘风险增加有关。对于在第6年出现持续性哮喘的儿童，他们的18月龄时T细胞受刺激后白细胞介素5（IL-5）和IL-13的合成增加，这与气道的早起细菌定植有关。这些发现突显了在儿童期出现不同哮喘表型的婴儿的早期独特免疫特征。
Distinct immune phenotypes in infants developing asthma during childhood
Anna Hammerich Thysen , Johannes Waage , Jeppe Madura Larsen , Morten Arendt Rasmussen , Jakob Stokholm , Bo Chawes , Nadia Rahman Fink , Tine Marie Pedersen , Helene Wolsk , Sunna Thorsteinsdottir , Thomas Litman , Harald Renz , Klaus Bønnelykke , Hans Bisgaard , Susanne Brix
Abstract
Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent disease at 6 years of age. An abnormal neutrophil-linked antiviral response was associated with increased risk of transient asthma. Children who exhibited persistent asthma at year 6 showed enhanced interleukin-5 (IL-5) and IL-13 production in stimulated T cells at 18 months of age, which was associated with early life bacterial colonization of the airways. These findings highlight the early appearance of distinct immune characteristics in infants developing different asthma endotypes during childhood.
早起暴露于环境触发因素可能会通过免疫应答失调而诱发慢性炎症性疾病。为了厘清早期免疫功能与儿童期哮喘发作之间的关系，我们对541名18月龄婴儿的血液的186项参数进行功能性免疫分析，并研究了其对应答表型与6岁时短暂或持续性疾病发作之间的联系。中性粒细胞相关的抗病毒应答异常与短暂性哮喘风险增加有关。对于在第6年出现持续性哮喘的儿童，他们的18月龄时T细胞受刺激后白细胞介素5（IL-5）和IL-13的合成增加，这与气道的早起细菌定植有关。这些发现突显了在儿童期出现不同哮喘表型的婴儿的早期独特免疫特征。
(中日友好医院呼吸与危重症医学科 张清 摘译 林江涛 审校)
(Sci Transl Med. 2020 Feb 5;12(529):eaaw0258. doi: 10.1126/scitranslmed.aaw0258.)
(Sci Transl Med. 2020 Feb 5;12(529):eaaw0258. doi: 10.1126/scitranslmed.aaw0258.)
Distinct immune phenotypes in infants developing asthma during childhood
Anna Hammerich Thysen , Johannes Waage , Jeppe Madura Larsen , Morten Arendt Rasmussen , Jakob Stokholm , Bo Chawes , Nadia Rahman Fink , Tine Marie Pedersen , Helene Wolsk , Sunna Thorsteinsdottir , Thomas Litman , Harald Renz , Klaus Bønnelykke , Hans Bisgaard , Susanne Brix
Abstract
Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent disease at 6 years of age. An abnormal neutrophil-linked antiviral response was associated with increased risk of transient asthma. Children who exhibited persistent asthma at year 6 showed enhanced interleukin-5 (IL-5) and IL-13 production in stimulated T cells at 18 months of age, which was associated with early life bacterial colonization of the airways. These findings highlight the early appearance of distinct immune characteristics in infants developing different asthma endotypes during childhood.
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哮喘的多维评估确定临床相关表型重叠：一项横断面研究
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基于肺外可治疗性状的哮喘表型鉴定
