加工肉制品摄入与哮喘症状的关系：法国健康营养网队列研究
2020/06/11
摘要
目的：加工肉制品摄入可能会对肺健康产生不利影响，但哮喘相关数据仍然很少。加工肉制品-哮喘相关行性的量级也可能取决于其他不健康行为。我们调查了加工肉制品摄入与哮喘症状评分之间的关系，以及不健康体重、吸烟、低饮食质量和高加工肉制品摄入对哮喘评分的联合作用。
方法：2017年，健康营养网队列的35380名参与者回答了一份详细的呼吸网络问卷。哮喘由哮喘症状评分（5个问题之和；连续变量）定义。根据在一个专门网站上收集的24小时重复饮食记录，加工肉制品摄入被归类为0，<2，2-5，>5份/周。我们检查了体质指数（BMI）（<25与≥25 kg/m2）、吸烟（从未与曾经）、饮食质量评分（最高与最低）和加工肉制品（<5与>5份/周）对哮喘症状评分的综合作用。
结果：参与者平均年龄54岁（女性75%，吸烟者49%，BMI≥25者32%，哮喘症状≥1者27%）。调整混杂因素后，加工肉制品摄入与哮喘症状评分呈显著正相：女性大于5次/周与0次/周的比值比（ORs）（95%CI）为1.15（1.04-1.27）；男性为1.23（1.01-1.50）。与无不良行为的受试者相比，有4种不良行为的受试者的哮喘症状评分，女性为2.18（1.91-2.48），男性为2.70（2.10-3.45）。
结论：高加工肉制品摄入与高哮喘症状评分相关，超重/肥胖、吸烟、低饮食质量、高加工肉制品摄入等综合因素与哮喘症状密切相关。
Association Between Processed Meat Intake and Asthma Symptoms in the French NutriNet-Santé Cohort.
Roland M Andrianasolo, Serge Hercberg, Mathilde Touvier, Nathalie Druesne-Pecollo, Moufidath Adjibade, Emmanuelle Kesse-Guyot, Pilar Galan, Raphaëlle Varraso.
Abstract
Purpose: Processed meat intake may adversely affect lung health, but data on asthma remains sparse. The magnitude of the processed meat-asthma association may also depend on other unhealthy behaviors. We investigated the association between processed meat intake and the asthma symptom score, and the combined role of unhealthy weight, smoking, low diet quality, and high processed meat intake on the asthma score.
METHODS: In 2017, 35,380 participants to the NutriNet-Santé cohort answered a detailed respiratory web-questionnaire. Asthma was defined by the asthma symptom score (sum of 5 questions; continuous variable). Based on repeated 24-h dietary records collected on a dedicated website, processed meat consumption was classified as 0, < 2, 2-5, > 5 servings/week. We examined the combined role of body mass index (BMI) (< 25 vs. ≥ 25 kg/m2), smoking (never vs. ever), diet quality score (highest vs. lowest), and processed meat (≤ 5 vs. > 5 servings/week) on the asthma symptom score.
RESULTS: Participants were aged 54 on average (women: 75%, smokers: 49%, BMI ≥ 25: 32%, ≥ 1 asthma symptoms: 27%). After adjustment for confounders, processed meat intake was positively and significantly associated with asthma symptom score: odds ratios (ORs) (95% CI) for > 5 vs. 0 servings/week were 1.15 (1.04-1.27) in women; 1.23 (1.01-1.50) in men. Compared to participants with 0 unhealthy behaviors, ORs for the asthma symptom score among participants with the 4 combined unhealthy behaviors were 2.18 (1.91-2.48) in women; 2.70 (2.10-3.45) in men.
CONCLUSIONS: High processed meat consumption was associated with higher asthma symptoms, and combining overweight/obesity, smoking, low diet quality, with high processed meat intake was strongly associated with asthma symptoms.
目的：加工肉制品摄入可能会对肺健康产生不利影响，但哮喘相关数据仍然很少。加工肉制品-哮喘相关行性的量级也可能取决于其他不健康行为。我们调查了加工肉制品摄入与哮喘症状评分之间的关系，以及不健康体重、吸烟、低饮食质量和高加工肉制品摄入对哮喘评分的联合作用。
方法：2017年，健康营养网队列的35380名参与者回答了一份详细的呼吸网络问卷。哮喘由哮喘症状评分（5个问题之和；连续变量）定义。根据在一个专门网站上收集的24小时重复饮食记录，加工肉制品摄入被归类为0，<2，2-5，>5份/周。我们检查了体质指数（BMI）（<25与≥25 kg/m2）、吸烟（从未与曾经）、饮食质量评分（最高与最低）和加工肉制品（<5与>5份/周）对哮喘症状评分的综合作用。
结果：参与者平均年龄54岁（女性75%，吸烟者49%，BMI≥25者32%，哮喘症状≥1者27%）。调整混杂因素后，加工肉制品摄入与哮喘症状评分呈显著正相：女性大于5次/周与0次/周的比值比（ORs）（95%CI）为1.15（1.04-1.27）；男性为1.23（1.01-1.50）。与无不良行为的受试者相比，有4种不良行为的受试者的哮喘症状评分，女性为2.18（1.91-2.48），男性为2.70（2.10-3.45）。
结论：高加工肉制品摄入与高哮喘症状评分相关，超重/肥胖、吸烟、低饮食质量、高加工肉制品摄入等综合因素与哮喘症状密切相关。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Eur J Nutr. 2020 Jun;59(4):1553-1562. doi: 10.1007/s00394-019-02011-7. Epub 2019 May 30.)
(Eur J Nutr. 2020 Jun;59(4):1553-1562. doi: 10.1007/s00394-019-02011-7. Epub 2019 May 30.)
Association Between Processed Meat Intake and Asthma Symptoms in the French NutriNet-Santé Cohort.
Roland M Andrianasolo, Serge Hercberg, Mathilde Touvier, Nathalie Druesne-Pecollo, Moufidath Adjibade, Emmanuelle Kesse-Guyot, Pilar Galan, Raphaëlle Varraso.
Abstract
Purpose: Processed meat intake may adversely affect lung health, but data on asthma remains sparse. The magnitude of the processed meat-asthma association may also depend on other unhealthy behaviors. We investigated the association between processed meat intake and the asthma symptom score, and the combined role of unhealthy weight, smoking, low diet quality, and high processed meat intake on the asthma score.
METHODS: In 2017, 35,380 participants to the NutriNet-Santé cohort answered a detailed respiratory web-questionnaire. Asthma was defined by the asthma symptom score (sum of 5 questions; continuous variable). Based on repeated 24-h dietary records collected on a dedicated website, processed meat consumption was classified as 0, < 2, 2-5, > 5 servings/week. We examined the combined role of body mass index (BMI) (< 25 vs. ≥ 25 kg/m2), smoking (never vs. ever), diet quality score (highest vs. lowest), and processed meat (≤ 5 vs. > 5 servings/week) on the asthma symptom score.
RESULTS: Participants were aged 54 on average (women: 75%, smokers: 49%, BMI ≥ 25: 32%, ≥ 1 asthma symptoms: 27%). After adjustment for confounders, processed meat intake was positively and significantly associated with asthma symptom score: odds ratios (ORs) (95% CI) for > 5 vs. 0 servings/week were 1.15 (1.04-1.27) in women; 1.23 (1.01-1.50) in men. Compared to participants with 0 unhealthy behaviors, ORs for the asthma symptom score among participants with the 4 combined unhealthy behaviors were 2.18 (1.91-2.48) in women; 2.70 (2.10-3.45) in men.
CONCLUSIONS: High processed meat consumption was associated with higher asthma symptoms, and combining overweight/obesity, smoking, low diet quality, with high processed meat intake was strongly associated with asthma symptoms.
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哮喘发作住院：一项中国大陆29个省份的中国哮喘研究网（CARN）回顾性研究
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重症哮喘患者生物标记物的前瞻性、单臂、纵向研究
