气道肌成纤维细胞在哮喘中的作用。
2020/02/11
摘要
气道重塑是哮喘的典型特征，被认为在气道高反应性的发病机理中起重要作用。肌成纤维细胞是参与损伤和修复的关键结构细胞，有证据表明其正常功能失调可导致气道重塑。尽管肌成纤维细胞很重要，但因缺乏特异性细胞标记物和不同的命名，限制了人们对其在气道重塑中关键作用的认知。在哮喘气道中，肌成纤维细胞的成倍增长与疾病的严重程度成比例关系。肌成纤维细胞被假定来源于组织原位细胞和骨髓衍生细胞，这取决于损伤的阶段和所在的组织。少数研究已表明，在哮喘和其他炎症过程中，肌成纤维细胞数量的减少和既定肌成纤维细胞的逆转。在本文中，我们回顾了哮喘气道中肌成纤维细胞生物学的目前已知，并确定了减少或逆转重塑过程的潜在目标。然而，需要进一步的翻译研究以更好地了解肌成纤维细胞在哮喘中的作用。
Nicholas G, et al. Chest. 2019 Aug 28.
Abstract
Airway remodelling is a characteristic feature of asthma and is thought to play an important role in the pathogenesis of airway hyperresponsiveness. Myofibroblasts are key structural cells involved in injury and repair, and there is evidence that dysregulation of their normal function contributes to airway remodeling. Despite the importance of myofibroblasts, a lack of specific cellular markers and inconsistent nomenclature has limited recognition of their key role in airway remodeling. Myofibroblasts are increased several-fold in the airways in asthma, in proportion to the severity of the disease. Myofibroblasts are postulated to be derived from both tissue-resident and bone marrow-derived cells, depending on the stage of injury and the tissue. A small number of studies have demonstrated attenuation of myofibroblast numbers and also reversal of established myofibroblast populations in asthma and other inflammatory processes. In this article, we review what is currently known about the biology of myofibroblasts in the airways in asthma and identify potential targets to reduce or reverse the remodeling process. However further translational research is required to better understand the mechanistic role of the myofibroblast in asthma.
气道重塑是哮喘的典型特征，被认为在气道高反应性的发病机理中起重要作用。肌成纤维细胞是参与损伤和修复的关键结构细胞，有证据表明其正常功能失调可导致气道重塑。尽管肌成纤维细胞很重要，但因缺乏特异性细胞标记物和不同的命名，限制了人们对其在气道重塑中关键作用的认知。在哮喘气道中，肌成纤维细胞的成倍增长与疾病的严重程度成比例关系。肌成纤维细胞被假定来源于组织原位细胞和骨髓衍生细胞，这取决于损伤的阶段和所在的组织。少数研究已表明，在哮喘和其他炎症过程中，肌成纤维细胞数量的减少和既定肌成纤维细胞的逆转。在本文中，我们回顾了哮喘气道中肌成纤维细胞生物学的目前已知，并确定了减少或逆转重塑过程的潜在目标。然而，需要进一步的翻译研究以更好地了解肌成纤维细胞在哮喘中的作用。
（中国医科大学附属第一医院 李文扬 摘译 杨冬 审校）
（Nicholas G, et al. Chest. 2019 Aug 28.）
The role of airway myofibroblasts in asthma.（Nicholas G, et al. Chest. 2019 Aug 28.）
Nicholas G, et al. Chest. 2019 Aug 28.
Abstract
Airway remodelling is a characteristic feature of asthma and is thought to play an important role in the pathogenesis of airway hyperresponsiveness. Myofibroblasts are key structural cells involved in injury and repair, and there is evidence that dysregulation of their normal function contributes to airway remodeling. Despite the importance of myofibroblasts, a lack of specific cellular markers and inconsistent nomenclature has limited recognition of their key role in airway remodeling. Myofibroblasts are increased several-fold in the airways in asthma, in proportion to the severity of the disease. Myofibroblasts are postulated to be derived from both tissue-resident and bone marrow-derived cells, depending on the stage of injury and the tissue. A small number of studies have demonstrated attenuation of myofibroblast numbers and also reversal of established myofibroblast populations in asthma and other inflammatory processes. In this article, we review what is currently known about the biology of myofibroblasts in the airways in asthma and identify potential targets to reduce or reverse the remodeling process. However further translational research is required to better understand the mechanistic role of the myofibroblast in asthma.
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88个变体突出了T细胞调节和气道重塑在哮喘发病机理中的作用
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调节性B和T细胞在蠕虫寄生诱导的对过敏性气道炎症中的关键作用
