了解哮喘中的夏科-雷登结晶
2020/02/11
摘要
夏科-雷登结晶通常存在于哮喘患者和长有鼻息肉的慢性鼻窦炎患者的气道粘液中。一项最近的研究表明，夏科-雷登结晶具有免疫原性且可被纳米抗体溶解，这代表了一项治疗过敏性气道疾病的实验性方法。
Making asthma crystal clear.
John V. Fahy, M.D., and Richard M. Locksley, M.D. N Engl J Med 2019; 381:882-884
Abstract
A recent study of Charcot–Leyden crystals, which are typically present in the airway mucus of persons with asthma and of persons with chronic rhinosinusitis with nasal polyps, indicates that they are immunogenic and that their dissolution — with the use of a nanobody — represents an experimental approach to treatment of allergic airway disease.
夏科-雷登结晶通常存在于哮喘患者和长有鼻息肉的慢性鼻窦炎患者的气道粘液中。一项最近的研究表明，夏科-雷登结晶具有免疫原性且可被纳米抗体溶解，这代表了一项治疗过敏性气道疾病的实验性方法。
（中国医科大学附属第一医院 李文扬 摘译 杨冬 审校）
（John V. Fahy, M.D., and Richard M. Locksley, M.D. N Engl J Med 2019; 381:882-884）
（John V. Fahy, M.D., and Richard M. Locksley, M.D. N Engl J Med 2019; 381:882-884）
Making asthma crystal clear.
John V. Fahy, M.D., and Richard M. Locksley, M.D. N Engl J Med 2019; 381:882-884
Abstract
A recent study of Charcot–Leyden crystals, which are typically present in the airway mucus of persons with asthma and of persons with chronic rhinosinusitis with nasal polyps, indicates that they are immunogenic and that their dissolution — with the use of a nanobody — represents an experimental approach to treatment of allergic airway disease.
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调节性B和T细胞在蠕虫寄生诱导的对过敏性气道炎症中的关键作用
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氯暴露通过固有淋巴细胞和CD11c中间型巨噬细胞加重哮喘炎症
