抑郁状态与哮喘及鼻炎控制不佳有关：一项基于人群的调查研究
2019/07/11
摘要
背景：尽管许多研究都强调了哮喘/鼻炎与抑郁症状态之间的关系，但目前仍不清楚这些疾病的哪些特征与抑郁症的风险有关。在意大利总人群中抽取代表性样本，目的是探讨抑郁症与哮喘或鼻炎之间的关系。
方法：这些数据是在意大利多中心，基于人群的多案例控制研究GEIRD中收集的。 2227名参与者（年龄21-86岁，女性50％）接受标准化问诊、皮肤点刺试验和肺功能测试，并分为当前哮喘病例组（n = 528），无哮喘的鼻炎组（n = 972）以及对照组（ N = 727）。询问来自患者健康问卷（PHQ-2）的两个具体问题以识别出抑郁情绪和快感缺乏的症状，这些症状代表抑郁症。
结果：哮喘组、鼻炎组及对照组患者抑郁症患病率分别为16.7％、11.9％及5.1％。与非抑郁症患者相比，哮喘和鼻炎组中，抑郁症患者的呼吸健康相关生活质量较差，疾病相关症状发生次数更多。在哮喘患者中，抑郁状态与疾病控制不良相关。在鼻炎组中，抑郁症与疾病相关的日常活动限制以及症状恶化并用药的风险增加显着相关。合并抑郁症的鼻炎患者特异性比例较小。
结论：我们的研究结果表明，鼻炎急性加重（尤其是非特异性患者），以及哮喘控制不佳与总人群中成人抑郁状态的存在密切相关。
Depression is associated with poor control of symptoms in asthma and rhinitis: A population-based study.
Grosso A, Pesce G, Marcon A, Piloni D, Albicini F, Gini E, Marchetti P, Battaglia S, Ferrari M, Fois A, Piccioni P, Antonicelli L, Verlato G, Corsico AG.
Abstract
Background：Although many studies have highlighted the link between asthma/rhinitis and depression, it is still unclear which characteristics of these diseases are associated with the risk of depression. We aimed to explore the relationship between depression and asthma or rhinitis in a representative sample of the Italian general population.
Methods：The data were collected in GEIRD, an Italian multicenter, population-based, multicase-control study. 2227 participants (age 21–86 years, female 50%) underwent standardized interviews, skin prick and lung function tests, and were divided into cases of current asthma (n = 528), rhinitis without asthma (n = 972), and controls (n = 727). Two specific questions from the Patient Health Questionnaire (PHQ-2) were asked to identify symptoms of depressed mood and anhedonia, which were used as a proxy of major depression disorder.
Results：The prevalence of depression was 16.7%, 11.9%, and 5.1% in subjects with asthma, rhinitis and controls, respectively. Both in asthma and rhinitis, subjects with depression had worse respiratory-health related quality of life and more frequent disease-related symptoms than their non-depressed counterparts. In asthma, depression was associated with poorer disease control. In rhinitis, depression was significantly associated with a disease-related limitations in daily activities and greater risk of symptom exacerbations and prescriptions of medicines for breathing. Cases of rhinitis with depression were less likely to be atopic.
Conclusions：Our results suggest that rhinitis exacerbations, particularly in non-atopic subjects, and low asthma control are strongly related to the presence of depressed mood in adults from the general population.
背景：尽管许多研究都强调了哮喘/鼻炎与抑郁症状态之间的关系，但目前仍不清楚这些疾病的哪些特征与抑郁症的风险有关。在意大利总人群中抽取代表性样本，目的是探讨抑郁症与哮喘或鼻炎之间的关系。
方法：这些数据是在意大利多中心，基于人群的多案例控制研究GEIRD中收集的。 2227名参与者（年龄21-86岁，女性50％）接受标准化问诊、皮肤点刺试验和肺功能测试，并分为当前哮喘病例组（n = 528），无哮喘的鼻炎组（n = 972）以及对照组（ N = 727）。询问来自患者健康问卷（PHQ-2）的两个具体问题以识别出抑郁情绪和快感缺乏的症状，这些症状代表抑郁症。
结果：哮喘组、鼻炎组及对照组患者抑郁症患病率分别为16.7％、11.9％及5.1％。与非抑郁症患者相比，哮喘和鼻炎组中，抑郁症患者的呼吸健康相关生活质量较差，疾病相关症状发生次数更多。在哮喘患者中，抑郁状态与疾病控制不良相关。在鼻炎组中，抑郁症与疾病相关的日常活动限制以及症状恶化并用药的风险增加显着相关。合并抑郁症的鼻炎患者特异性比例较小。
结论：我们的研究结果表明，鼻炎急性加重（尤其是非特异性患者），以及哮喘控制不佳与总人群中成人抑郁状态的存在密切相关。
（中日友好医院呼吸与危重症医学科 张鑫 摘译 林江涛 审校）
（Respir Med. 2019 Jun 30;155:6-12）
（Respir Med. 2019 Jun 30;155:6-12）
Depression is associated with poor control of symptoms in asthma and rhinitis: A population-based study.
Grosso A, Pesce G, Marcon A, Piloni D, Albicini F, Gini E, Marchetti P, Battaglia S, Ferrari M, Fois A, Piccioni P, Antonicelli L, Verlato G, Corsico AG.
Abstract
Background：Although many studies have highlighted the link between asthma/rhinitis and depression, it is still unclear which characteristics of these diseases are associated with the risk of depression. We aimed to explore the relationship between depression and asthma or rhinitis in a representative sample of the Italian general population.
Methods：The data were collected in GEIRD, an Italian multicenter, population-based, multicase-control study. 2227 participants (age 21–86 years, female 50%) underwent standardized interviews, skin prick and lung function tests, and were divided into cases of current asthma (n = 528), rhinitis without asthma (n = 972), and controls (n = 727). Two specific questions from the Patient Health Questionnaire (PHQ-2) were asked to identify symptoms of depressed mood and anhedonia, which were used as a proxy of major depression disorder.
Results：The prevalence of depression was 16.7%, 11.9%, and 5.1% in subjects with asthma, rhinitis and controls, respectively. Both in asthma and rhinitis, subjects with depression had worse respiratory-health related quality of life and more frequent disease-related symptoms than their non-depressed counterparts. In asthma, depression was associated with poorer disease control. In rhinitis, depression was significantly associated with a disease-related limitations in daily activities and greater risk of symptom exacerbations and prescriptions of medicines for breathing. Cases of rhinitis with depression were less likely to be atopic.
Conclusions：Our results suggest that rhinitis exacerbations, particularly in non-atopic subjects, and low asthma control are strongly related to the presence of depressed mood in adults from the general population.
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