早期呼吸道病毒感染与儿童哮喘的发展:系统回顾和荟萃分析的方案
2019/06/13
摘要
背景：呼吸道病毒是导致儿童早期喘息的主要原因，这可能有助于儿童哮喘的发展，导致发病率和社会经济负担的增加。本综述的目的是确定一岁时呼吸道病毒感染是否与儿童哮喘的发生有关。
方法：我们将使用截短和短语搜索关键词以及相关主题标题搜索主要的科学数据库(MEDLINE、CINAHL、Web of Science、Cochrane Library和clinicaltry .gov)。英语发表的观察研究包括病例对照研究、队列研究和随机对照试验将纳入本综述。病例报告、定性研究和叙述综述将被排除在外。暴露将被定义为出生后第一年经实验室确认的病毒性呼吸道感染，结果将被定义为5岁至18岁之间哮喘的发展。在双变量和多变量分析中，效果将以发病率或患病率来表示。我们将在所有研究中探索标准误差的异质性，如果合适的话，我们将使用随机效应模型进行meta分析，以估计总体的发病率或患病率。
结果：这篇综述将评估一岁时呼吸道病毒感染是否会增加儿童哮喘发展的风险。
结论：本系统综述将评估已发表的文献，评估早期病毒感染与儿童哮喘之间的关系。汇集的数据可能提供证据表明，婴儿呼吸道病毒感染导致复发性喘息和哮喘的发生率更高，从而提高进一步研究疫苗等药物干预措施和向幼儿提供洗手和呼吸道卫生促进等非药物干预措施的成本效益。实施这类研究的结果可能会减轻急性病毒性呼吸道感染以及随后喘息和哮喘复发的负担。
系统回顾注册:本系统综述已在PROSPERO (CRD42018105519)上注册。
Respiratory viral infection in early life and development of asthma in childhood: A protocol for systematic review and meta-analysis.
Hassan MZ, Chowdhury MAB, Hassan I, Chowdhury F, Schaefer N, Chisti MJ.
Abstract
BACKGROUND:Respiratory viruses are the leading cause of early life wheezing that may contribute to the development of childhood asthma leading to increasing morbidity and socioeconomic burden. The aim of this review is to identify whether respiratory viral infections during first year of life were associated with development of childhood asthma.
METHODS:We will search major scientific databases (MEDLINE, CINAHL, Web of Science, Cochrane Library, and ClinicalTrials.gov) using truncated and phrase-searched keywords and relevant subject headings. Observational studies including case-control studies, cohort studies, and randomized control trails published in English will be included in this review. Case reports, qualitative studies, and narrative overviews will be excluded. Exposure will be defined as laboratory-confirmed viral respiratory tract infection in the first year of life and outcome will be defined as development of asthma between ages 5 and 18 years. Effect sizes in bivariate and multivariate analyses will be presented as odds or prevalence ratios. We will explore for heterogeneity of the standard errors across the studies, and if appropriate, we will perform a meta-analysis using a random-effects model to present a summary estimate of the odds or prevalence ratios.
RESULTS:This review will assess whether respiratory viral infections during first year of life increases the risk of childhood asthma development.
CONCLUSIONS:This systematic review will evaluate published literature, assessing the link between early life viral infection and childhood asthma. Pooled data may provide evidence that infantile respiratory viral infection results in higher incidence of recurrent wheezing and asthma, thereby stimulating further research into the cost-effectiveness of pharmaceutical interventions such as vaccines and nonpharmaceutical interventions such as hand-washing and respiratory hygiene promotion to young children. Implementing the results of such research may then reduce the burden of acute viral respiratory infections and subsequent recurrent wheezing and asthma.
SYSTEMATIC REVIEW REGISTRATION:This systematic review has been registered on PROSPERO (CRD42018105519).
背景：呼吸道病毒是导致儿童早期喘息的主要原因，这可能有助于儿童哮喘的发展，导致发病率和社会经济负担的增加。本综述的目的是确定一岁时呼吸道病毒感染是否与儿童哮喘的发生有关。
方法：我们将使用截短和短语搜索关键词以及相关主题标题搜索主要的科学数据库(MEDLINE、CINAHL、Web of Science、Cochrane Library和clinicaltry .gov)。英语发表的观察研究包括病例对照研究、队列研究和随机对照试验将纳入本综述。病例报告、定性研究和叙述综述将被排除在外。暴露将被定义为出生后第一年经实验室确认的病毒性呼吸道感染，结果将被定义为5岁至18岁之间哮喘的发展。在双变量和多变量分析中，效果将以发病率或患病率来表示。我们将在所有研究中探索标准误差的异质性，如果合适的话，我们将使用随机效应模型进行meta分析，以估计总体的发病率或患病率。
结果：这篇综述将评估一岁时呼吸道病毒感染是否会增加儿童哮喘发展的风险。
结论：本系统综述将评估已发表的文献，评估早期病毒感染与儿童哮喘之间的关系。汇集的数据可能提供证据表明，婴儿呼吸道病毒感染导致复发性喘息和哮喘的发生率更高，从而提高进一步研究疫苗等药物干预措施和向幼儿提供洗手和呼吸道卫生促进等非药物干预措施的成本效益。实施这类研究的结果可能会减轻急性病毒性呼吸道感染以及随后喘息和哮喘复发的负担。
系统回顾注册:本系统综述已在PROSPERO (CRD42018105519)上注册。
（中日友好医院呼吸与危重症医学科 禹汶伯 摘译 林江涛 审校）
（Medicine(Baltimore).2019May;98(18):e15419.doi:10.1097/MD.000000000001541.）
（Medicine(Baltimore).2019May;98(18):e15419.doi:10.1097/MD.000000000001541.）
Respiratory viral infection in early life and development of asthma in childhood: A protocol for systematic review and meta-analysis.
Hassan MZ, Chowdhury MAB, Hassan I, Chowdhury F, Schaefer N, Chisti MJ.
Abstract
BACKGROUND:Respiratory viruses are the leading cause of early life wheezing that may contribute to the development of childhood asthma leading to increasing morbidity and socioeconomic burden. The aim of this review is to identify whether respiratory viral infections during first year of life were associated with development of childhood asthma.
METHODS:We will search major scientific databases (MEDLINE, CINAHL, Web of Science, Cochrane Library, and ClinicalTrials.gov) using truncated and phrase-searched keywords and relevant subject headings. Observational studies including case-control studies, cohort studies, and randomized control trails published in English will be included in this review. Case reports, qualitative studies, and narrative overviews will be excluded. Exposure will be defined as laboratory-confirmed viral respiratory tract infection in the first year of life and outcome will be defined as development of asthma between ages 5 and 18 years. Effect sizes in bivariate and multivariate analyses will be presented as odds or prevalence ratios. We will explore for heterogeneity of the standard errors across the studies, and if appropriate, we will perform a meta-analysis using a random-effects model to present a summary estimate of the odds or prevalence ratios.
RESULTS:This review will assess whether respiratory viral infections during first year of life increases the risk of childhood asthma development.
CONCLUSIONS:This systematic review will evaluate published literature, assessing the link between early life viral infection and childhood asthma. Pooled data may provide evidence that infantile respiratory viral infection results in higher incidence of recurrent wheezing and asthma, thereby stimulating further research into the cost-effectiveness of pharmaceutical interventions such as vaccines and nonpharmaceutical interventions such as hand-washing and respiratory hygiene promotion to young children. Implementing the results of such research may then reduce the burden of acute viral respiratory infections and subsequent recurrent wheezing and asthma.
SYSTEMATIC REVIEW REGISTRATION:This systematic review has been registered on PROSPERO (CRD42018105519).
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