英国生物样本库的全基因组跨性状分析突出强调了哮喘和过敏性疾病的共同遗传结构
2018/11/14
摘要
临床和流行病学数据表明，哮喘和过敏性疾病是相关的，可能有共同的遗传病因。我们分析了来自英国生物样本库中具有欧洲血统的33,593例患者和76,768例对照人群的哮喘和过敏性疾病的全基因组SNP数据。两个公开可用的独立全基因组关联研究均用于本研究。我们在哮喘和过敏性疾病之间发现了强大的全基因组遗传相关性（rg = 0.75，P = 6.84×10-62）。跨性状分析鉴定了38个全基因组显著位点，包括7个新的共有基因座。计算分析表明，共享的基因位点在免疫/炎症系统和具有上皮细胞的组织中含量丰富。我们的工作确定了哮喘和过敏之间共有的共同遗传结构，这将有助于促进对共患哮喘和过敏性疾病分子机制的理解。
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
Zhu Z, Lee PH, Chaffin MD, Chung W, Loh PR, Lu Q, Christiani DC, Liang L.
Abstract
Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK Biobank. Two publicly available independent genome-wide association studies were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (rg = 0.75, P = 6.84 × 10-62). Cross-trait analysis identified 38 genome-wide significant loci, including 7 novel shared loci. Computational analysis showed that shared genetic loci are enriched in immune/inflammatory systems and tissues with epithelium cells. Our work identifies common genetic architectures shared between asthma and allergy and will help to advance understanding of the molecular mechanisms underlying co-morbid asthma and allergic diseases.
临床和流行病学数据表明，哮喘和过敏性疾病是相关的，可能有共同的遗传病因。我们分析了来自英国生物样本库中具有欧洲血统的33,593例患者和76,768例对照人群的哮喘和过敏性疾病的全基因组SNP数据。两个公开可用的独立全基因组关联研究均用于本研究。我们在哮喘和过敏性疾病之间发现了强大的全基因组遗传相关性（rg = 0.75，P = 6.84×10-62）。跨性状分析鉴定了38个全基因组显著位点，包括7个新的共有基因座。计算分析表明，共享的基因位点在免疫/炎症系统和具有上皮细胞的组织中含量丰富。我们的工作确定了哮喘和过敏之间共有的共同遗传结构，这将有助于促进对共患哮喘和过敏性疾病分子机制的理解。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Nat Genet. 2018 Jun;50(6):857-864. )
(Nat Genet. 2018 Jun;50(6):857-864. )
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
Zhu Z, Lee PH, Chaffin MD, Chung W, Loh PR, Lu Q, Christiani DC, Liang L.
Abstract
Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK Biobank. Two publicly available independent genome-wide association studies were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (rg = 0.75, P = 6.84 × 10-62). Cross-trait analysis identified 38 genome-wide significant loci, including 7 novel shared loci. Computational analysis showed that shared genetic loci are enriched in immune/inflammatory systems and tissues with epithelium cells. Our work identifies common genetic architectures shared between asthma and allergy and will help to advance understanding of the molecular mechanisms underlying co-morbid asthma and allergic diseases.
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内皮细胞与过敏原先天反应和变应性哮喘发生
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1型和3型干扰素产生的发育调控以及婴儿感染与哮喘发展的风险(JACI)
