气道上皮细胞衍生的集落刺激因子-1促进过敏原致敏
2018/11/02
摘要
气道上皮细胞（AEC）可分泌固有免疫细胞因子来调节适应性免疫效应细胞。在过敏原致敏的人和小鼠中，气道和肺泡微环境富含集落刺激因子-1（CSF1）以响应过敏原暴露。在本研究中，我们发现AEC衍生的CSF1在过敏原反应性IgE产物的合成中起关键作用。此外，时空性分泌的CSF1调节肺泡树突细胞（DC）的募集并且增强干扰素调节因子4（IRF4）依赖的常规DC2（cDC2）向引流淋巴结的迁移。 CSF1选择性地上调CSF1R+ cDC2而不是cDC1上的趋化因子受体CCR7的表达以响应过敏原的刺激。我们的数据描述了CSF1依赖性DC亚群的功能，其连接T辅助细胞2（Th2）细胞介导的过敏性肺部炎症中的先天性和适应性免疫应答。
Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization.
Moon HG, Kim SJ, Jeong JJ, Han SS, Jarjour NN, Lee H, Abboud-Werner SL, Chung S, Choi HS, Natarajan V, Ackerman SJ, Christman JW, Park GY.
Summary
Airway epithelial cells (AECs) secrete innate immune cytokines that regulate adaptive immune effector cells. In allergen-sensitized humans and mice, the airway and alveolar microenvironment is enriched with colony stimulating factor-1 (CSF1) in response to allergen exposure. In this study we found that AEC-derived CSF1 had a critical role in the production of allergen reactive-IgE production. Furthermore, spatiotemporally secreted CSF1 regulated the recruitment of alveolar dendritic cells (DCs) and enhanced the migration of conventional DC2s (cDC2s) to the draining lymph node in an interferon regulatory factor 4 (IRF4)-dependent manner. CSF1 selectively upregulated the expression of the chemokine receptor CCR7 on the CSF1R+ cDC2, but not the cDC1, population in response to allergen stimuli. Our data describe the functional specification of CSF1-dependent DC subsets that link the innate and adaptive immune responses in T helper 2 (Th2) cell-mediated allergic lung inflammation.
气道上皮细胞（AEC）可分泌固有免疫细胞因子来调节适应性免疫效应细胞。在过敏原致敏的人和小鼠中，气道和肺泡微环境富含集落刺激因子-1（CSF1）以响应过敏原暴露。在本研究中，我们发现AEC衍生的CSF1在过敏原反应性IgE产物的合成中起关键作用。此外，时空性分泌的CSF1调节肺泡树突细胞（DC）的募集并且增强干扰素调节因子4（IRF4）依赖的常规DC2（cDC2）向引流淋巴结的迁移。 CSF1选择性地上调CSF1R+ cDC2而不是cDC1上的趋化因子受体CCR7的表达以响应过敏原的刺激。我们的数据描述了CSF1依赖性DC亚群的功能，其连接T辅助细胞2（Th2）细胞介导的过敏性肺部炎症中的先天性和适应性免疫应答。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Immunity. 2018 Jul 13. pii: S1074-7613(18)30291-7.)
(Immunity. 2018 Jul 13. pii: S1074-7613(18)30291-7.)
Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization.
Moon HG, Kim SJ, Jeong JJ, Han SS, Jarjour NN, Lee H, Abboud-Werner SL, Chung S, Choi HS, Natarajan V, Ackerman SJ, Christman JW, Park GY.
Summary
Airway epithelial cells (AECs) secrete innate immune cytokines that regulate adaptive immune effector cells. In allergen-sensitized humans and mice, the airway and alveolar microenvironment is enriched with colony stimulating factor-1 (CSF1) in response to allergen exposure. In this study we found that AEC-derived CSF1 had a critical role in the production of allergen reactive-IgE production. Furthermore, spatiotemporally secreted CSF1 regulated the recruitment of alveolar dendritic cells (DCs) and enhanced the migration of conventional DC2s (cDC2s) to the draining lymph node in an interferon regulatory factor 4 (IRF4)-dependent manner. CSF1 selectively upregulated the expression of the chemokine receptor CCR7 on the CSF1R+ cDC2, but not the cDC1, population in response to allergen stimuli. Our data describe the functional specification of CSF1-dependent DC subsets that link the innate and adaptive immune responses in T helper 2 (Th2) cell-mediated allergic lung inflammation.
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