家务和职业清洁与肺功能衰退和气道阻塞相关
2018/08/16
摘要
论据：清洁任务可能意味着接触对呼吸系统有潜在有害影响的化学制剂，有研究发现职业清洁人员和家庭清洁人员中哮喘和呼吸道症状的风险增加。 然而，清洁剂对呼吸系统健康的长期影响尚未得到很好的描述。
目标：本研究旨在探讨职业清洁和家庭清洁对肺功能下降和气道阻塞的长期影响。
方法：欧洲共同体呼吸健康调查组织（ECRHS）在20多年的三个时间点进行了一项基于多中心的人群调查。 研究纳入了来自22个研究中心的总共6,235名参与者，其中每人至少进行过一次肺功能测定，他们在ECRHS II中回答了关于ECRHS I和ECRHS II之间清洁活动的问卷模块。 数据使用混合线性模型分析，并调整潜在的混杂因素。
结果：与未从事清洁的妇女（ΔFEV1= -18.5 ml /年）相比，负责家庭清洁的妇女（-22.1; P = 0.01）和职业清洁人员（-22.4; P = 0.03）的FEV1下降得更快。 FVC下降的情况也是如此（未从事清洁的妇女ΔFVC= -8.8ml / 年）（ 负责家庭清洁的妇女-13.1，P = 0.02）（职业清洁人员-15.9，P = 0.002）。 清洁喷雾剂和其他清洁剂均与加速的FEV1下降相关（分别为-22.0，P = 0.04;和-22.9，P = 0.004）。 清洁与男性肺功能下降或FEV1 / FVC下降或气道阻塞无明显相关性。
结论：负责家庭清洁的妇女或作为职业清洁人员的妇女肺功能加速下降，这表明与清洁活动有关的暴露可能对长期呼吸系统健康构成风险。
Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction.
Øistein S, Randi J. B, et al.
Am J Respir Crit Care Med. 2018 May 1.
Abstract
Rationale：Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cleaners and in persons cleaning at home has been reported. Long-term consequences of cleaning agents on respiratory health are, however, not well described.
Objective：This study aimed to investigate long-term effects of occupational cleaning and cleaning at home on lung function decline and airway obstruction.
Methods：The European Community Respiratory Health Survey(ECRHS) investigated a multicenter population-based cohort at three time points over 20 years. A total of 6,235 participants with at least one lung function measurement from 22 study centers, who in ECRHS II responded to questionnaire modules concerning cleaning activities between ECRHS I and ECRHS II, were included. The data were analyzed with mixed linear models adjusting for potential confounders.
Results：As compared with women not engaged in cleaning (ΔFEV1 = -18.5 ml/yr), FEV1 declined more rapidly in women responsible for cleaning at home (-22.1; P = 0.01) and occupational cleaners (-22.4; P = 0.03). The same was found for decline in FVC (ΔFVC = -8.8 ml/yr; -13.1, P = 0.02; and -15.9, P = 0.002; respectively). Both cleaning sprays and other cleaning agents were associated with accelerated FEV1 decline (-22.0, P = 0.04; and -22.9, P = 0.004; respectively). Cleaning was not significantly associated with lung function decline in men or with FEV1/FVC decline or airway obstruction.
Conclusion ：Women cleaning at home or working as occupational cleaners had accelerated decline in lung function, suggesting that exposures related to cleaning activities may constitute a risk to long-term respiratory health.
论据：清洁任务可能意味着接触对呼吸系统有潜在有害影响的化学制剂，有研究发现职业清洁人员和家庭清洁人员中哮喘和呼吸道症状的风险增加。 然而，清洁剂对呼吸系统健康的长期影响尚未得到很好的描述。
目标：本研究旨在探讨职业清洁和家庭清洁对肺功能下降和气道阻塞的长期影响。
方法：欧洲共同体呼吸健康调查组织（ECRHS）在20多年的三个时间点进行了一项基于多中心的人群调查。 研究纳入了来自22个研究中心的总共6,235名参与者，其中每人至少进行过一次肺功能测定，他们在ECRHS II中回答了关于ECRHS I和ECRHS II之间清洁活动的问卷模块。 数据使用混合线性模型分析，并调整潜在的混杂因素。
结果：与未从事清洁的妇女（ΔFEV1= -18.5 ml /年）相比，负责家庭清洁的妇女（-22.1; P = 0.01）和职业清洁人员（-22.4; P = 0.03）的FEV1下降得更快。 FVC下降的情况也是如此（未从事清洁的妇女ΔFVC= -8.8ml / 年）（ 负责家庭清洁的妇女-13.1，P = 0.02）（职业清洁人员-15.9，P = 0.002）。 清洁喷雾剂和其他清洁剂均与加速的FEV1下降相关（分别为-22.0，P = 0.04;和-22.9，P = 0.004）。 清洁与男性肺功能下降或FEV1 / FVC下降或气道阻塞无明显相关性。
结论：负责家庭清洁的妇女或作为职业清洁人员的妇女肺功能加速下降，这表明与清洁活动有关的暴露可能对长期呼吸系统健康构成风险。
（复旦大学附属中山医院呼吸内科 罗锦龙 摘译 杨冬 审校）
（Am J Respir Crit Care Med. 2018 May 1.）
（Am J Respir Crit Care Med. 2018 May 1.）
Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction.
Øistein S, Randi J. B, et al.
Am J Respir Crit Care Med. 2018 May 1.
Abstract
Rationale：Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cleaners and in persons cleaning at home has been reported. Long-term consequences of cleaning agents on respiratory health are, however, not well described.
Objective：This study aimed to investigate long-term effects of occupational cleaning and cleaning at home on lung function decline and airway obstruction.
Methods：The European Community Respiratory Health Survey(ECRHS) investigated a multicenter population-based cohort at three time points over 20 years. A total of 6,235 participants with at least one lung function measurement from 22 study centers, who in ECRHS II responded to questionnaire modules concerning cleaning activities between ECRHS I and ECRHS II, were included. The data were analyzed with mixed linear models adjusting for potential confounders.
Results：As compared with women not engaged in cleaning (ΔFEV1 = -18.5 ml/yr), FEV1 declined more rapidly in women responsible for cleaning at home (-22.1; P = 0.01) and occupational cleaners (-22.4; P = 0.03). The same was found for decline in FVC (ΔFVC = -8.8 ml/yr; -13.1, P = 0.02; and -15.9, P = 0.002; respectively). Both cleaning sprays and other cleaning agents were associated with accelerated FEV1 decline (-22.0, P = 0.04; and -22.9, P = 0.004; respectively). Cleaning was not significantly associated with lung function decline in men or with FEV1/FVC decline or airway obstruction.
Conclusion ：Women cleaning at home or working as occupational cleaners had accelerated decline in lung function, suggesting that exposures related to cleaning activities may constitute a risk to long-term respiratory health.
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