1999-2015年美国与哮喘相关的死亡率:一项死亡相关的多因素分析
2018/06/04
摘要
背景：基于基本死因（UCOD）的哮喘死亡率低估了疾病的负担。
目的：因此，本研究应用多种死因（MCOD）记录对从1999年至2015年美国哮喘的死亡率及其死亡证明中哮喘与其并发症的报告模式进行了分析。
方法：对1999 - 2015年间156517份提及哮喘的死亡证书进行了分析。其中哮喘的定义是ICD-10代码J45，其死亡率为基于UCOD或MCOD的死亡率并根据年龄、性别和种族/民族计算年龄校正后每年的哮喘死亡率。还评估了6304例MCOD编码的哮喘（J46）。
结果：在1999 - 2015年间，共发生59067例哮喘患者死亡（基于UCOD），其中女性37832人，男性21235人（F / M = 1.78）。共发生156517例哮喘患者死亡（基于MCOD），其中女性101371人，男性55146人（F / M = 1.83）。其中任何提及哮喘的死亡人数中有37.7％患者为基于UCOD的死亡率，女性为37.3％，男性为38.45％。该百分比为西班牙裔白人（HW）中的比例，而非西班牙裔黑人（NHB）中比例为41.7％，非西班牙裔白人（NHW）中的比例为36％。在1999 - 2015年期间，年龄调整后MCOD死亡率变化如下：女性HW -38.1％，NHB -34.1％和NHW -15.1％;男性HW-28.5％，NHB -21.3％和NHW -25.0％。 NHB女性和男性在整个期间的MCOD和UCOD死亡率最高。
结论：在任何提及哮喘的死亡人群中，哮喘UCOD死亡率在NHB男性中最多，在NHW女性中最少。按年龄调整的MCOD死亡率在NHW男性中下降最多，NHW女性中下降最低。
Asthma-Related Mortality in the United States of America, 1999-2015: A Multiple Causes of Death Analysis
Ann Allergy Asthma Immunol, 2018 Mar 13.
Abstract
BACKGROUND：Asthma mortality based on the underlying cause of death (UCOD) underestimates disease burden.
OBJECTIVE：Therefore, in this study, asthma mortality in the US 1999-2015 was analyzed, as well as the pattern of reporting of asthma and its co-morbidities in death certificates, using multiple-cause of death (MCOD) records.
METHODS：All 156,517 death certificates with any mention of asthma were analyzed for 1999-2015. Asthma was defined by ICD-10 code J45 based either on the UCOD or MCOD. Annual age-adjusted asthma death rates were computed according to age, gender and race/ethnicity. The 6,304 MCOD coded status asthmaticus (J46) were also examined.
RESULTS：In years of 1999-2015 a total of 59,067 deaths with UCOD of asthma occurred, of which 37,832 were females and 21,235 were males (F/M = 1.78). A total of 156,517 deaths with MCOD of asthma occurred, of which 101,371 were females and 55,146 were males (F/M=1.83). Hence 37.7% of deaths with any mention of asthma had asthma as the UCOD, 37.3% females and 38.45% males. Percents were White Hispanics (HW), 41.7% in non-Hispanic blacks (NHB) and 36% in non-Hispanic whites (NHW). Between 1999-2015, age adjusted MCOD death rates changed as follows: Females HW -38.1%, NHB -34.1%, and NHW -15.1%; Males HW -28.5%, NHB -21.3% and NHW -25.0%. NHB females and males had the highest MCOD and UCOD rates throughout the period.
CONCLUSION：Among deaths with any mention of asthma, asthma was chosen as UCOD most often in NHBM and least often in NHWF. Age-adjusted MCOD rates declined most in NHWM and least in NHWF.
背景：基于基本死因（UCOD）的哮喘死亡率低估了疾病的负担。
目的：因此，本研究应用多种死因（MCOD）记录对从1999年至2015年美国哮喘的死亡率及其死亡证明中哮喘与其并发症的报告模式进行了分析。
方法：对1999 - 2015年间156517份提及哮喘的死亡证书进行了分析。其中哮喘的定义是ICD-10代码J45，其死亡率为基于UCOD或MCOD的死亡率并根据年龄、性别和种族/民族计算年龄校正后每年的哮喘死亡率。还评估了6304例MCOD编码的哮喘（J46）。
结果：在1999 - 2015年间，共发生59067例哮喘患者死亡（基于UCOD），其中女性37832人，男性21235人（F / M = 1.78）。共发生156517例哮喘患者死亡（基于MCOD），其中女性101371人，男性55146人（F / M = 1.83）。其中任何提及哮喘的死亡人数中有37.7％患者为基于UCOD的死亡率，女性为37.3％，男性为38.45％。该百分比为西班牙裔白人（HW）中的比例，而非西班牙裔黑人（NHB）中比例为41.7％，非西班牙裔白人（NHW）中的比例为36％。在1999 - 2015年期间，年龄调整后MCOD死亡率变化如下：女性HW -38.1％，NHB -34.1％和NHW -15.1％;男性HW-28.5％，NHB -21.3％和NHW -25.0％。 NHB女性和男性在整个期间的MCOD和UCOD死亡率最高。
结论：在任何提及哮喘的死亡人群中，哮喘UCOD死亡率在NHB男性中最多，在NHW女性中最少。按年龄调整的MCOD死亡率在NHW男性中下降最多，NHW女性中下降最低。
(中国医科大学附属第一医院呼吸与危重症医学科 李文扬 摘译 杨冬 审校)
(Ann Allergy Asthma Immunol, 2018 Mar 13.)
(Ann Allergy Asthma Immunol, 2018 Mar 13.)
Asthma-Related Mortality in the United States of America, 1999-2015: A Multiple Causes of Death Analysis
Ann Allergy Asthma Immunol, 2018 Mar 13.
Abstract
BACKGROUND：Asthma mortality based on the underlying cause of death (UCOD) underestimates disease burden.
OBJECTIVE：Therefore, in this study, asthma mortality in the US 1999-2015 was analyzed, as well as the pattern of reporting of asthma and its co-morbidities in death certificates, using multiple-cause of death (MCOD) records.
METHODS：All 156,517 death certificates with any mention of asthma were analyzed for 1999-2015. Asthma was defined by ICD-10 code J45 based either on the UCOD or MCOD. Annual age-adjusted asthma death rates were computed according to age, gender and race/ethnicity. The 6,304 MCOD coded status asthmaticus (J46) were also examined.
RESULTS：In years of 1999-2015 a total of 59,067 deaths with UCOD of asthma occurred, of which 37,832 were females and 21,235 were males (F/M = 1.78). A total of 156,517 deaths with MCOD of asthma occurred, of which 101,371 were females and 55,146 were males (F/M=1.83). Hence 37.7% of deaths with any mention of asthma had asthma as the UCOD, 37.3% females and 38.45% males. Percents were White Hispanics (HW), 41.7% in non-Hispanic blacks (NHB) and 36% in non-Hispanic whites (NHW). Between 1999-2015, age adjusted MCOD death rates changed as follows: Females HW -38.1%, NHB -34.1%, and NHW -15.1%; Males HW -28.5%, NHB -21.3% and NHW -25.0%. NHB females and males had the highest MCOD and UCOD rates throughout the period.
CONCLUSION：Among deaths with any mention of asthma, asthma was chosen as UCOD most often in NHBM and least often in NHWF. Age-adjusted MCOD rates declined most in NHWM and least in NHWF.
