成人哮喘EGEA研究：氧化应激标志物和临床特征
2018/01/05
摘要
哮喘是一种氧化应激相关疾病，但在成人哮喘中氧化应激与哮喘转归之间的关系稍有研究。本研究旨在探索不同氧化应激相关炎症标志物与不同哮喘转归的关系。针对1388名成人进行横断面研究，平均年龄43岁，其中44%为哮喘患者，即哮喘基因和环境流行病学研究（EGEA2）。三种血液抗氧化酶活性（针对氧化应激的炎症标志物）、呼出气凝集8-异前列腺素和血浆荧光氧化产物（FIOPs）（两种损伤性标志物）进行测定。生物标志物与以下相关性：1）哮喘病史；2）哮喘发作、控制以及哮喘患者肺功能情况；通过回归方程经年龄、性别和吸烟状态进行调整后分析。反应后的生物标志物与哮喘转归无关。高水平8-异前列腺素与哮喘发生显著相关（OR：1.25；95%CI:1.06-1.67）。哮喘患者中，高水平8-异前列腺素与成人起病哮喘呈负相关（0.63，0.41-0.97），而FIOPs水平与哮喘发作（1.33，1.07-1.65），哮喘未控制（1.30，1.02-1.66）和较差肺功能（1.34，1.04-1.74）显著相关。研究结果提示8-异前列腺素与儿童期起病哮喘相关，而FIOPs与哮喘表达相关。
（上海交通大学医学院附属瑞金医院呼吸与危重症医学科 周剑平 万欢英 摘译）
（Eur Respir J. 2017 Dec 28;50(6). pii: 1701193. doi: 10.1183/13993003.01193-2017. Print 2017 Dec. ）
Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study.
Eur Respir J. 2017 Dec 28;50(6). pii: 1701193. doi: 10.1183/13993003.01193-2017. Print 2017 Dec.
Andrianjafimasy M, Zerimech F, Akiki Z, Huyvaert H, Le Moual N, Siroux V, Matran R, Dumas O, Nadif R.
Abstract
Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06-1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41-0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07-1.65), poor asthma control (1.30, 1.02-1.66) and poor lung function (1.34, 1.04-1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.
上一篇：
呼出气一氧化氮检测对于疑似哮喘患者的诊断准确性：一项系统回顾和Meta分析
下一篇：
重症嗜酸性粒细胞性哮喘生物学标记物
